24 Recruiting Trials
Clinical Trials
for Multiple Sclerosis in Illinois
24 clinical trials for Multiple Sclerosis are currently recruiting participants at study sites in Illinois. Study-related care is provided at no cost.
24
Recruiting trials
18
Study sites
5
Cities
7
Industry-sponsored
1
Phase 2
6
Phase 3
Multiple Sclerosis clinical trials in Illinois: what to expect
Multiple sclerosis trials divide into relapsing and progressive forms. Relapsing MS studies test new oral and infused disease-modifying therapies, usually against an approved medicine rather than a placebo. Progressive MS has fewer approved options, so trials there test drugs meant to slow disability, protect nerves or repair myelin, and often do use a placebo. Alongside these are trials of rehabilitation, exercise, diet, fatigue and bladder treatments, and studies that simply follow people over time with MRI and blood tests.
In Illinois, recruiting multiple sclerosis studies are concentrated in Chicago, Urbana, Evanston and Champaign, with sites in 1 other city. 7 of the 24 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who multiple sclerosis trials usually look for
Listings state the type of MS, an age range (commonly 18 to 55 for relapsing trials, up to 65 for progressive) and a disability score range measured by the study neurologist. Relapsing trials usually want a relapse or new MRI activity in the past one to two years. Drug trials require a washout from your current therapy, which varies from weeks to months by drug and is managed by the site. Symptom and rehabilitation trials let you stay on your treatment.
What taking part involves
Screening includes a neurological exam, blood work and an MRI. Drug trials then run one to three years with visits every one to three months, an MRI every six to twelve months and a relapse assessment whenever symptoms change. Relapses are treated as normal. The study drug, scans and visits are free, and an extension usually lets everyone continue the active treatment afterwards. Rehabilitation trials involve sessions over eight to twenty-four weeks with walking, hand and cognition tests.
Questions worth asking the study team
What the comparison treatment is; how the washout from your current therapy is handled and how long it lasts; how many MRIs are needed; whether there is an extension; and what happens if you relapse during the study.
Showing 20 of 24 recruiting Multiple Sclerosis trials in Illinois
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Recruiting
This trial is looking for adults aged 18-65 with secondary progressive multiple sclerosis (SPMS). Participants will take the medication remibrutinib and have regular assessments to evaluate its effects.
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Recruiting
This trial is looking for adults between 18 to 60 years old with Multiple Sclerosis. Participants will receive frexalimab either by injection under the skin or through an IV every four weeks for a year.
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
Recruiting
This trial is looking for children and adolescents with relapsing remitting multiple sclerosis (MS). Participants will take either ozanimod or fingolimod and help researchers understand how well these treatments work and their effects on the body.
Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis
Recruiting
This trial is looking for adults aged 18 to 70 who have been diagnosed with early forms of relapsing multiple sclerosis. Participants will receive the medication Ublituximab twice a year while the effects are monitored over about 12 months.
The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis
Recruiting
This trial is looking for adults with multiple sclerosis to see how a 16-week Pilates exercise program delivered online affects their physical and mental well-being. Participants will either take part in the exercise program or be put on a waitlist.
Functional Balance Intervention in Multiple Sclerosis
Recruiting
This trial is looking for adults aged 55-80 with Multiple Sclerosis. Participants will take part in training sessions either in a lab or at home to help improve balance and cognitive functions over four months.
Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
Recruiting
This trial is looking for people with multiple sclerosis and depression to see how different exercise programs can help manage their symptoms. Participants will engage in structured exercise training and complete various questionnaires throughout the study.
Intermittent Hypoxia in Persons With Multiple Sclerosis
Recruiting
This trial is looking for adults with multiple sclerosis to explore a breathing treatment that involves short periods of low oxygen. Participants will have their brain activity and ankle strength measured before and after the treatment.
Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS
Recruiting
This trial is looking for people with multiple sclerosis to see how a breathing technique affects arm and hand function. Participants will go through the breathing technique and have their muscle responses measured before and after the intervention.
Home Based Functional Balance Intervention for Multiple Sclerosis
Recruiting
This trial is looking for people with multiple sclerosis who want to improve their physical and cognitive abilities. Participants will take part in a balance training program over four months, joining sessions online through Zoom.
An Individualized-health eLibrary App for People With Multiple Sclerosis
Recruiting
This trial is looking for people with multiple sclerosis to try a new health app called SavvyHealth. Participants will use the app for 21 days and complete surveys about their experience.
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
Recruiting
This trial is looking for people with a confirmed diagnosis of relapsing multiple sclerosis who are starting treatment with BRIUMVI®. Participants will receive the medication and share their experiences and results during the study.
Ocrevus Zunovo for MS: Mixed Methods
Recruiting
This trial is looking for people with multiple sclerosis who are interested in starting or restarting a specific treatment called Ocrevus Zunovo. Participants will share their experiences through surveys and interviews over a year.
People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists
Recruiting
This trial is looking for adults with multiple sclerosis who have received Ocrelizumab treatment. Participants will be monitored over 72 weeks to assess changes in their condition.
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
Recruiting
This trial is looking for adults with treatment-resistant multiple sclerosis. Participants will be randomly assigned to receive either stem cell transplantation or the best available therapy and will be followed for 6 years.
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Recruiting
This trial is looking for people with relapsing multiple sclerosis who have been treated with ocrelizumab and want to switch to remibrutinib. Participants will take remibrutinib and their health will be monitored.
Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain
Recruiting
This trial is looking for individuals aged 18 to 75 who experience spasticity, pain, or muscle reflex issues due to neurological or neuromuscular conditions. Participants will wear a special electrostimulation suit to see if it helps with their symptoms.
Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device
Recruiting
This trial is looking for adults with multiple sclerosis who primarily use a wheelchair for mobility. Participants will engage in a personalized exercise rehabilitation program aimed at improving muscle strength and reducing fatigue.
Remote Evaluation of MIND Diet
Recruiting
This trial is looking for adults with Multiple Sclerosis to see if following the MIND diet can help improve their thinking and memory. Participants will eat meals based on this diet for 3 months and complete some online surveys and tests about their cognitive abilities.
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
Recruiting
This trial is looking for people with relapsing multiple sclerosis. Participants will receive a modified treatment of ublituximab and help researchers understand its effectiveness and safety.
Where the Multiple Sclerosis studies are in Illinois
Research sites running the most studies
- Northwestern Memorial Hospital, Chicago4 trials
- Shirley Ryan AbilityLab, Chicago4 trials
- University of Illinois at Chicago, Chicago4 trials
- Rush University Medical Center, Chicago2 trials
- TG Therapeutics Investigational Trial Site, Chicago2 trials
- University of Chicago Medical Center, Chicago2 trials
By city
- Chicago19
- Urbana3
- Evanston2
- Champaign1
- Northbrook1
Counts are recruiting studies listing at least one site in Illinois, from ClinicalTrials.gov, refreshed every two days.
Multiple Sclerosis clinical trials in Illinois: common questions
How many Multiple Sclerosis clinical trials are recruiting in Illinois?
TrialFinder currently lists 24 recruiting Multiple Sclerosis clinical trials with study sites in Illinois. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Multiple Sclerosis clinical trials located in Illinois?
Study sites for the Multiple Sclerosis trials listed on this page include Chicago, Champaign, Evanston, Urbana. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Multiple Sclerosis clinical trial in Illinois?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Multiple Sclerosis trials in Illinois also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Multiple Sclerosis clinical trial in Illinois?
Each study sets its own criteria based on age, Multiple Sclerosis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I get a placebo instead of MS treatment?
In relapsing MS almost never: trials compare the new drug with an approved medicine, so everyone is treated. Progressive MS trials more often use a placebo because fewer approved treatments exist, and an extension usually follows.
Do I need to stop my current MS medicine to join?
For a drug trial, yes, after a washout that depends on your current medicine and is supervised by the study neurologist. Trials of rehabilitation, diet or symptom treatments let you continue it.
What is an EDSS score?
The Expanded Disability Status Scale, a 0 to 10 score a neurologist assigns from an exam, mostly based on walking. Trials set a range, and the study neurologist scores you at screening; you do not need to know it in advance.
Multiple Sclerosis Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Multiple Sclerosis Trials
MS trials investigate disease-modifying therapies, remyelination strategies, stem-cell transplants, and neuroprotective agents for relapsing and progressive forms of MS.
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