Breathing Intervention for Multiple Sclerosis
Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS
Recruiting
N/A
Interventional Study
Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting
Multiple Sclerosis, Secondary Progressive
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 75
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 22 (estimated)
- Sponsor
- Shirley Ryan AbilityLab · Other
Who this trial is looking for
This trial is looking for people with multiple sclerosis to see how a breathing technique affects arm and hand function. Participants will go through the breathing technique and have their muscle responses measured before and after the intervention.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with relapsing-remitting multiple sclerosis.
- I have been relapse-free for at least 6 months.
- My Expanded Disability Status Scale score is 7 or lower.
- I have difficulty with finger strength or hand function.
- I have been on stable disease modifying treatments for at least 6 months.
- If I take dalfampridine, I have been on the same dose for at least 2 months.
You may not be able to join if
- I have a diagnosis affecting my upper limb function.
- My Mini-Mental State Examination score is below 24.
- My Modified Ashworth Scale score is above 3 on my elbow.
- I have uncontrolled high or low blood pressure.
- I have a history of epilepsy, COPD, or sleep apnea.
- I have unstable medical conditions or ongoing treatment for my upper limbs.
- I am currently experiencing musculoskeletal pain.
- I am pregnant.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
This study seeks to explore changes in the neural pathways and arm function following a breathing intervention in the multiple sclerosis (MS) population. The breathing intervention, known as Acute Intermittent Hypoxia (AIH), involves breathing brief bouts of low levels of oxygen. Research has found AIH to be a safe and effective intervention resulting in increased ankle strength in people with MS.…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Diagnosis of relapsing-remitting MS according to the McDonald criteria, over 5 years ago
* Relapse free for at least 6 months
* Expanded Disability Status Scale (EDSS) ≤7
* Index finger abduction strength \<5 according to Medical Research Council Scale, or 9-Hole Peg Test scor…
Contacts