No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
150 (estimated)
Sponsor
Northwestern University · Other
Who this trial is looking for
This trial is looking for people with multiple sclerosis who are interested in starting or restarting a specific treatment called Ocrevus Zunovo. Participants will share their experiences through surveys and interviews over a year.
Are You a Good Fit for This Trial?
Rules you outHypogammaglobulinemiaLeukopeniaActive hepatitisTuberculosisCurrent serious infection
You may be able to join if
I am 18 years old or older
I live in the USA
I have been seen at Northwestern Medicine
I have a confirmed diagnosis of MS
I want to start or restart a treatment for MS
I am willing to participate in a 12-month follow-up study
You may not be able to join if
I have an unclear diagnosis of MS
I am currently in prison
I cannot give informed consent
I am currently participating in another trial for MS
I have a serious or terminal illness
I cannot speak a language that consent forms are available in
I am currently pregnant or breastfeeding
I have had an allergic reaction to Ocrelizumab or similar treatments
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Ocrevus Zunovo implementation, feasibility, acceptability, patient satisfaction, treatment persistence, and impact on MS disease outcomes will be analyzed in this mixed methods study. This study will incorporate clinical data and questionnaire results from MS patients who take Ocrevus Zunovo as well as qualitative interviews with MS patients, family members, and other individuals involved in Ocrev…
Ocrevus Zunovo implementation, feasibility, acceptability, patient satisfaction, treatment persistence, and impact on MS disease outcomes will be analyzed in this mixed methods study. This study will incorporate clinical data and questionnaire results from MS patients who take Ocrevus Zunovo as well as qualitative interviews with MS patients, family members, and other individuals involved in Ocrevus Zunovo treatment. The purpose of this study is to synthesize implementation strategies that improve patient access to high-efficacy MS therapies in real-world settings.
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
* Age of 18 years or older
* Resident of the USA
* Seen at Northwestern Medicine
* Meets diagnostic criteria (2024) for MS, either RMS or PPMS
* Diagnosis of MS (G35) on file by a neurologist
* Wants to start or restart a DMT for MS
* Willing to be in a 12-month follow up study
…
Inclusion Criteria:
* Age of 18 years or older
* Resident of the USA
* Seen at Northwestern Medicine
* Meets diagnostic criteria (2024) for MS, either RMS or PPMS
* Diagnosis of MS (G35) on file by a neurologist
* Wants to start or restart a DMT for MS
* Willing to be in a 12-month follow up study
Exclusion Criteria:
* Unclear diagnosis of MS
* Incarcerated
* Unable to provide informed consent
* Current participant in an MS or any experimental therapy clinical trial
* Moribund
* Unable to speak a language for which consent processes are available at Northwestern Hospitals
* Currently taking a DMT that has not been washed out (e.g. recent treatment with Cladribine, Natalizumab, sphingosine 1-phosphate inhibitor, implying the last DMT is still actively immunosuppressing the patient)
* Current chemotherapy
* History of stem cell transplant, CAR-T or other chemo-ablative procedures
* Unwilling to complete surveys over the course of the following 12 months
* No access to computer or telephone
* Prior allergic reaction or intolerance to Ocrelizumab IV or SubQ or any monoclonal antibody therapy
* Hypogammaglobulinemia IgG level \<500
* Leukopenia \<2.0
* Active hepatitis or latent hepatitis B
* Elevated liver enzymes 3 times the upper limit of normal
* Tuberculosis
* Current serious infection, e.g. COVID-19, shingles, active pneumonia, progressive multifocal leukoencephalopathy, etc.
* Currently pregnant, breastfeeding, or a person of childbearing capacity who is sexually active without a documented plan of current contraceptive methods.
* Any other diagnosis or reason deemed to make the participant unfit for participation by the study PI
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