Ocrevus Zunovo for MS: Mixed Methods

Inclusion Criteria: * Age of 18 years or older * Resident of the USA * Seen at Northwestern Medicine * Meets diagnostic criteria (2024) for MS, either RMS or PPMS * Diagnosis of MS (G35) on file by a neurologist * Wants to start or restart a DMT for MS * Willing to be in a 12-month follow up study Exclusion Criteria: * Unclear diagnosis of MS * Incarcerated * Unable to provide informed consent * Current participant in an MS or any experimental therapy clinical trial * Moribund * Unable to speak a language for which consent processes are available at Northwestern Hospitals * Currently taking a DMT that has not been washed out (e.g. recent treatment with Cladribine, Natalizumab, sphingosine 1-phosphate inhibitor, implying the last DMT is still actively immunosuppressing the patient) * Current chemotherapy * History of stem cell transplant, CAR-T or other chemo-ablative procedures * Unwilling to complete surveys over the course of the following 12 months * No access to computer or telephone * Prior allergic reaction or intolerance to Ocrelizumab IV or SubQ or any monoclonal antibody therapy * Hypogammaglobulinemia IgG level \<500 * Leukopenia \<2.0 * Active hepatitis or latent hepatitis B * Elevated liver enzymes 3 times the upper limit of normal * Tuberculosis * Current serious infection, e.g. COVID-19, shingles, active pneumonia, progressive multifocal leukoencephalopathy, etc. * Currently pregnant, breastfeeding, or a person of childbearing capacity who is sexually active without a documented plan of current contraceptive methods. * Any other diagnosis or reason deemed to make the participant unfit for participation by the study PI