Multiple Sclerosis Trials / Trials in Florida
19 Recruiting Trials

Clinical Trials
for Multiple Sclerosis in Florida

19 clinical trials for Multiple Sclerosis are currently recruiting participants at study sites in Florida. Study-related care is provided at no cost.

19
Recruiting trials
52
Study sites
21
Cities
14
Industry-sponsored
3
Phase 2
7
Phase 3

Multiple Sclerosis clinical trials in Florida: what to expect

Multiple sclerosis trials divide into relapsing and progressive forms. Relapsing MS studies test new oral and infused disease-modifying therapies, usually against an approved medicine rather than a placebo. Progressive MS has fewer approved options, so trials there test drugs meant to slow disability, protect nerves or repair myelin, and often do use a placebo. Alongside these are trials of rehabilitation, exercise, diet, fatigue and bladder treatments, and studies that simply follow people over time with MRI and blood tests.

In Florida, recruiting multiple sclerosis studies are concentrated in Tampa, Naples, Maitland and Gainesville, with sites in 17 other cities. 14 of the 19 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who multiple sclerosis trials usually look for

Listings state the type of MS, an age range (commonly 18 to 55 for relapsing trials, up to 65 for progressive) and a disability score range measured by the study neurologist. Relapsing trials usually want a relapse or new MRI activity in the past one to two years. Drug trials require a washout from your current therapy, which varies from weeks to months by drug and is managed by the site. Symptom and rehabilitation trials let you stay on your treatment.

What taking part involves

Screening includes a neurological exam, blood work and an MRI. Drug trials then run one to three years with visits every one to three months, an MRI every six to twelve months and a relapse assessment whenever symptoms change. Relapses are treated as normal. The study drug, scans and visits are free, and an extension usually lets everyone continue the active treatment afterwards. Rehabilitation trials involve sessions over eight to twenty-four weeks with walking, hand and cognition tests.

Questions worth asking the study team

What the comparison treatment is; how the washout from your current therapy is handled and how long it lasts; how many MRIs are needed; whether there is an extension; and what happens if you relapse during the study.

Showing 19 of 19 recruiting Multiple Sclerosis trials in Florida

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
PHASE3 Birmingham, Alabama +4 sites NCT07225504
This trial is looking for adults aged 18-65 with secondary progressive multiple sclerosis (SPMS). Participants will take the medication remibrutinib and have regular assessments to evaluate its effects.
Recruiting
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
PHASE3 Cullman, Alabama +4 sites NCT07325292
This trial is looking for adults between 18 to 60 years old with Multiple Sclerosis. Participants will receive frexalimab either by injection under the skin or through an IV every four weeks for a year.
Recruiting
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
PHASE3 Tampa, Florida +4 sites NCT06408259
This trial is looking for children and adolescents with relapsing remitting multiple sclerosis (MS). Participants will take either ozanimod or fingolimod and help researchers understand how well these treatments work and their effects on the body.
Recruiting
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
PHASE2 Naples, Florida +4 sites NCT06782490
This trial is looking for people with multiple sclerosis (MS) who experience muscle stiffness for at least 6 months. Participants will help evaluate the safety and effectiveness of a new treatment.
Recruiting
A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy
PHASE4 Maitland, Florida +4 sites NCT07609719
This trial is looking for people with relapsing or primary progressive multiple sclerosis who are changing from another anti-CD20 treatment. Participants will receive ocrelizumab combined with an additional medication through injections and will be monitored for their health outcomes and side effects.
Recruiting
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for MS
PHASE1 Naples, Florida +1 sites NCT05003388
Recruiting
Dry Needling in Multiple Sclerosis
NA Tampa, Florida NCT07615725
This trial is looking for people with Multiple Sclerosis who have had pain in their legs for at least three months. Participants will receive either real dry needling treatment or a fake version to see if it helps reduce their pain and improve daily activities.
Recruiting
Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
NA Gainesville, Florida +1 sites NCT07376772
This trial is looking for adults with relapsing-remitting multiple sclerosis (MS) who have difficulty using their arms or hands. Participants will try a wearable device for 4 weeks to see if it helps improve their arm function.
Recruiting
Effects of Torso Weighting on Muscle Activation During Balance Tests in Individuals With and Without Multiple Sclerosis
NA Saint Augustine, Florida NCT06981013
This trial is looking for people with multiple sclerosis and healthy controls. Participants will help researchers understand how torso weighting affects balance and muscle activation during balance tests.
Recruiting
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
N/A Birmingham, Alabama +4 sites NCT06433752
This trial is looking for people with a confirmed diagnosis of relapsing multiple sclerosis who are starting treatment with BRIUMVI®. Participants will receive the medication and share their experiences and results during the study.
Recruiting
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
PHASE3 Altamonte Springs, Florida +4 sites NCT06846281
This trial is looking for people with relapsing multiple sclerosis who have been treated with ocrelizumab and want to switch to remibrutinib. Participants will take remibrutinib and their health will be monitored.
Recruiting
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
PHASE3 Phoenix, Arizona +4 sites NCT07299019
This trial is looking for people with Secondary Progressive Multiple Sclerosis who have not had a clinical relapse for at least 2 years. Participants will receive either orelabrutinib or a placebo for 1 to 5 years.
Recruiting
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
PHASE3 Bradenton, Florida +4 sites NCT07067463
This trial is looking for people with Primary Progressive Multiple Sclerosis (PPMS). Participants will take either the study drug orelabrutinib or a placebo for about 30 to 60 months, with at least 12 months of treatment.
Recruiting
Clinical Applications of Advanced Ophthalmic Imaging
NA Miami, Florida NCT03135327
This trial is looking for individuals with eye conditions such as diabetic retinopathy or multiple sclerosis to test advanced eye imaging and the effects of an over-the-counter medical food called Ocufolin over 6 months. Participants will undergo eye imaging and follow instructions related to the study.
Recruiting
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
PHASE3 Birmingham, Alabama +4 sites NCT05877963
This trial is looking for people with relapsing multiple sclerosis. Participants will receive a modified treatment of ublituximab and help researchers understand its effectiveness and safety.
Recruiting
Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers
PHASE1 Jacksonville, Florida +2 sites NCT05395624
This trial is looking for people with conditions like ALS, Alzheimer's, multiple sclerosis, and Parkinson's disease. Participants will be given a treatment called 18F-OP-801 to see how safe it is and how it works in their bodies.
Recruiting
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
PHASE2 Birmingham, Alabama +4 sites NCT07002034
This trial is looking for people who have been diagnosed with Adjustment Disorder due to cancer or certain other health conditions. Participants will receive a single dose of the study drug to see if it helps reduce their depressive or anxiety symptoms.
Recruiting
Neurologic Stem Cell Treatment Study
NA Coral Springs, Florida +2 sites NCT02795052
This trial is looking for adults with certain neurologic conditions who have not improved with standard treatments. Participants will undergo a procedure involving their own stem cells to see if it helps with their symptoms.
Recruiting
Longitudinal Cognitive Assessment by BoCA
N/A Miami, Florida NCT04114994
This trial is looking for people aged 50 and older to participate in an online cognitive test. The test helps track thinking skills over time and is free for participants.
Recruiting
See all 19 Multiple Sclerosis trials in Florida

Where the Multiple Sclerosis studies are in Florida

Research sites running the most studies
  • Aqualane Clinical Research, Naples4 trials
  • Neurology Associates PA, Maitland2 trials
  • Neurology Associates, PA, Maitland2 trials
  • Neurology of Central FL Res Ctr, Altamonte Springs2 trials
  • Nova Clinical Research, LLC, Bradenton2 trials
  • Orlando Health Clinical Trials, Orlando2 trials
By city

Counts are recruiting studies listing at least one site in Florida, from ClinicalTrials.gov, refreshed every two days.

Multiple Sclerosis clinical trials in Florida: common questions

How many Multiple Sclerosis clinical trials are recruiting in Florida?
TrialFinder currently lists 19 recruiting Multiple Sclerosis clinical trials with study sites in Florida. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Multiple Sclerosis clinical trials located in Florida?
Study sites for the Multiple Sclerosis trials listed on this page include Tampa, Naples, Maitland, Gainesville, Saint Augustine, Altamonte Springs. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Multiple Sclerosis clinical trial in Florida?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Multiple Sclerosis trials in Florida also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Multiple Sclerosis clinical trial in Florida?
Each study sets its own criteria based on age, Multiple Sclerosis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I get a placebo instead of MS treatment?
In relapsing MS almost never: trials compare the new drug with an approved medicine, so everyone is treated. Progressive MS trials more often use a placebo because fewer approved treatments exist, and an extension usually follows.
Do I need to stop my current MS medicine to join?
For a drug trial, yes, after a washout that depends on your current medicine and is supervised by the study neurologist. Trials of rehabilitation, diet or symptom treatments let you continue it.
What is an EDSS score?
The Expanded Disability Status Scale, a 0 to 10 score a neurologist assigns from an exam, mostly based on walking. Trials set a range, and the study neurologist scores you at screening; you do not need to know it in advance.
Multiple Sclerosis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Multiple Sclerosis Trials

MS trials investigate disease-modifying therapies, remyelination strategies, stem-cell transplants, and neuroprotective agents for relapsing and progressive forms of MS.

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