Breast Cancer Trials / Trials in Florida
241 Recruiting Trials

Clinical Trials
for Breast Cancer in Florida

241 clinical trials for Breast Cancer are currently recruiting participants at study sites in Florida. Study-related care is provided at no cost.

241
Recruiting trials
326
Study sites
62
Cities
129
Industry-sponsored
82
Phase 2
41
Phase 3

Breast Cancer clinical trials in Florida: what to expect

Breast cancer trials are sorted first by subtype, because the treatments differ: hormone-receptor-positive, HER2-positive (including the newer HER2-low group) and triple-negative disease each have their own studies. Most recruiting trials test a new drug or combination, including targeted pills, antibody-drug conjugates and immunotherapy, either for metastatic cancer or before and after surgery for early-stage disease. Others study less surgery or radiation, ways to reduce recurrence, and screening for people at higher risk.

In Florida, recruiting breast cancer studies are concentrated in Tampa, Jacksonville, Miami and Orlando, with sites in 58 other cities. 129 of the 241 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who breast cancer trials usually look for

Listings name the subtype, the stage (early or metastatic) and how many treatments you may already have had. Early-stage trials often enroll between diagnosis and surgery, or in the months after surgery; metastatic trials usually enroll when a treatment has stopped working. Some specify menopausal status or a particular mutation (BRCA, PIK3CA, ESR1), which the site can test for. Nearly all require that you are well enough for daily activity and that recent blood work is adequate.

Your receptor status is on your pathology report; the site will confirm it from that report, so you do not need to know it by heart to ask.

What taking part involves

Screening reviews your pathology and scans and adds blood work, sometimes a biopsy. Treatment then runs in cycles, with infusions every two to three weeks or daily pills, and scans every two to three months to check the response. Early-stage trials follow you for years after treatment ends, usually with a visit or call every few months. Study drugs and study-specific tests are free; care you would receive anyway is billed to insurance as usual. Placebo, when used, is added to standard treatment.

Questions worth asking the study team

How the study treatment compares with what your oncologist would otherwise recommend; whether the trial is randomized and what the other arm receives; what happens if the cancer grows or returns; and how visits fit around work and family. Many trials now allow some visits at a local clinic.

Showing 20 of 241 recruiting Breast Cancer trials in Florida

Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
PHASE3 Jonesboro, Arkansas +4 sites NCT06757634
This trial is looking for adults with advanced breast cancer that is HR-positive and HER2-negative. Participants will receive treatment involving gedatolisib along with other medications.
Recruiting
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
PHASE3 Goodyear, Arizona +4 sites NCT06790693
This trial is looking for adults with a specific type of advanced breast cancer to test a new treatment combo. Participants will receive either the new treatment or a placebo along with standard care.
Recruiting
A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer
PHASE3 Largo, Florida +4 sites NCT07205822
This trial is looking for adults with a specific type of advanced breast cancer. Participants will receive the treatment Dato-DXd and will need to provide a tumor sample and meet certain health requirements.
Recruiting
Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy
PHASE3 Jacksonville, Florida +4 sites NCT05856773
This trial is looking for women with breast cancer who need radiation therapy. Participants will receive either a shorter treatment course of 3 weeks or a standard course of 5 weeks using a specific type of radiation called proton therapy.
Recruiting
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
PHASE3 Greenbrae, California +4 sites NCT05646862
This trial is looking for people with advanced breast cancer that has specific mutations and has not improved after certain treatments. Participants will compare two treatment combinations to see which is more effective and safe.
Recruiting
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
PHASE3 Daphne, Alabama +4 sites NCT06103864
This trial is looking for patients with a specific type of breast cancer that is not treatable by surgery. Participants will receive a treatment called Dato-DXd, with or without another drug, or a standard chemotherapy treatment.
Recruiting
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
PHASE3 Hot Springs, Arkansas +4 sites NCT07085767
This trial is looking for adults with advanced breast cancer that hasn’t been treated before. Participants will receive palazestrant with ribociclib or letrozole with ribociclib to see which treatment works better.
Recruiting
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
PHASE3 Daphne, Alabama +4 sites NCT06492616
This trial is looking for women and men with early breast cancer that has a high risk of coming back. Participants will compare the effects of elacestrant with standard treatment after being on another therapy for a while.
Recruiting
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
PHASE3 Birmingham, Alabama +4 sites NCT05879926
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
Recruiting
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
PHASE3 Phoenix, Arizona +4 sites NCT06072612
This trial is looking for adults with advanced or locally recurrent breast cancer who have run out of treatment options. Participants will receive treatment with the Bria-IMT regimen and a checkpoint inhibitor to see how well it works compared to other standard treatments.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer
PHASE3 Miami Beach, Florida +4 sites NCT05950945
This trial is looking for people with certain types of breast cancer to see how a treatment called trastuzumab deruxtecan works. Participants need to provide tissue samples and meet specific health criteria.
Recruiting
Phase III Trial of Brain MRI Surveillance in Stage IV Breast Cancer
PHASE3 Miami, Florida +1 sites NCT07357298
This trial is looking for women with stage IV breast cancer who do not have symptoms affecting their brain. Participants will get brain MRI scans every 6 months to see if this helps find brain issues earlier.
Recruiting
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
PHASE1 Huntsville, Alabama +4 sites NCT07100106
This trial is looking for people with advanced breast cancer that is hormone receptor positive and HER2 negative. Participants will receive GDC-4198 by itself or with another drug, Giredestrant, to see how well it works and compare it to another treatment option.
Recruiting
To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer
PHASE2 Jacksonville, Florida +4 sites NCT07368998
This trial is looking for adults with a specific type of breast cancer who have had treatment before. Participants will take a combination of two medications and help researchers understand their effects.
Recruiting
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
PHASE2 Jacksonville, Florida +4 sites NCT07405801
This trial is looking for people with advanced breast cancer that has not responded to hormone treatments. Participants will receive a combination of medications to see how effective they are compared to a placebo.
Recruiting
A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
PHASE2 Fort Lauderdale, Florida +4 sites NCT07102381
This trial is looking for people with early-stage HER2-positive breast cancer to see if zanidatamab combined with chemotherapy is safe and effective. Participants will need to undergo surgery after the treatment.
Recruiting
A Study of SDX-7320 in Combination With Eribulin for People With Breast Cancer
PHASE2 Miami, Florida +4 sites NCT05570253
This trial is looking for people with advanced breast cancer that has spread and certain metabolic issues. Participants will receive a combination of the study drug SDX-7320 and the chemotherapy drug eribulin, and researchers will assess how effective this treatment is compared to eribulin alone.
Recruiting
A Study Evaluating the Feasibility and Compliance of Manual Lymphatic Drainage Comparing Indocyanine-Green (ICG) Guided vs. Traditional Guided in Patients Undergoing Axillary Node Dissection for the Treatment of Breast Cancer
PHASE2 Gainesville, Florida NCT06327490
Recruiting
Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer
PHASE2 Jacksonville, Florida +4 sites NCT07076485
This trial is looking for individuals with certain types of breast cancer who have had surgery. Participants will receive shorter schedules of special radiation treatment to see how it affects their cancer risk.
Recruiting
See all 241 Breast Cancer trials in Florida

Where the Breast Cancer studies are in Florida

Research sites running the most studies
  • Moffitt Cancer Center, Tampa43 trials
  • Mayo Clinic in Florida, Jacksonville26 trials
  • University of Miami, Miami15 trials
  • Mount Sinai Medical Center, Miami Beach11 trials
  • Miami Cancer Institute, Miami10 trials
  • University of Florida, Gainesville10 trials
By city

Counts are recruiting studies listing at least one site in Florida, from ClinicalTrials.gov, refreshed every two days.

Breast Cancer clinical trials in Florida: common questions

How many Breast Cancer clinical trials are recruiting in Florida?
TrialFinder currently lists 241 recruiting Breast Cancer clinical trials with study sites in Florida. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Breast Cancer clinical trials located in Florida?
Study sites for the Breast Cancer trials listed on this page include Largo, Jacksonville, Miami Beach, Miami, Fort Lauderdale, Gainesville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Breast Cancer clinical trial in Florida?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Breast Cancer trials in Florida also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Breast Cancer clinical trial in Florida?
Each study sets its own criteria based on age, Breast Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to know my receptor status to join a breast cancer trial?
It helps, because trials are organized by subtype, but the study site reads it from your pathology report. If a trial needs a test you have not had, such as HER2-low or a BRCA result, the site arranges it.
Are there trials for early-stage breast cancer?
Yes. Early-stage trials enroll before surgery, after surgery, or during the years of hormone therapy that follow, and test ways to lower the chance the cancer returns. The listing says which window it enrolls in.
Will a trial replace the treatment my oncologist planned?
Sometimes it is the plan, with a new drug added or compared; sometimes it is an alternative to discuss. Bring the trial page to your oncologist, who can refer you to the site or advise on timing.
Breast Cancer Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Breast Cancer Trials

Breast cancer trials test new chemotherapy regimens, immunotherapy combinations, targeted therapies, and early-detection methods across all stages of breast cancer.

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