56 Recruiting Trials

Clinical Trials
for Breast Cancer in District of Columbia

56 clinical trials for Breast Cancer are currently recruiting participants at study sites in District of Columbia. Study-related care is provided at no cost.

56
Recruiting trials
38
Study sites
1
City
25
Industry-sponsored
15
Phase 2
19
Phase 3

Breast Cancer clinical trials in District of Columbia: what to expect

Breast cancer trials are sorted first by subtype, because the treatments differ: hormone-receptor-positive, HER2-positive (including the newer HER2-low group) and triple-negative disease each have their own studies. Most recruiting trials test a new drug or combination, including targeted pills, antibody-drug conjugates and immunotherapy, either for metastatic cancer or before and after surgery for early-stage disease. Others study less surgery or radiation, ways to reduce recurrence, and screening for people at higher risk.

In District of Columbia, recruiting breast cancer studies are concentrated in Washington D.C.. 25 of the 56 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who breast cancer trials usually look for

Listings name the subtype, the stage (early or metastatic) and how many treatments you may already have had. Early-stage trials often enroll between diagnosis and surgery, or in the months after surgery; metastatic trials usually enroll when a treatment has stopped working. Some specify menopausal status or a particular mutation (BRCA, PIK3CA, ESR1), which the site can test for. Nearly all require that you are well enough for daily activity and that recent blood work is adequate.

Your receptor status is on your pathology report; the site will confirm it from that report, so you do not need to know it by heart to ask.

What taking part involves

Screening reviews your pathology and scans and adds blood work, sometimes a biopsy. Treatment then runs in cycles, with infusions every two to three weeks or daily pills, and scans every two to three months to check the response. Early-stage trials follow you for years after treatment ends, usually with a visit or call every few months. Study drugs and study-specific tests are free; care you would receive anyway is billed to insurance as usual. Placebo, when used, is added to standard treatment.

Questions worth asking the study team

How the study treatment compares with what your oncologist would otherwise recommend; whether the trial is randomized and what the other arm receives; what happens if the cancer grows or returns; and how visits fit around work and family. Many trials now allow some visits at a local clinic.

Showing 20 of 56 recruiting Breast Cancer trials in District of Columbia

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
PHASE3 Anchorage, Alaska +4 sites NCT07062965
This trial is looking for people with HR-positive, HER2-negative advanced breast cancer that has worsened after previous treatment. Participants will receive the study medicine PF-07248144 along with their normal treatment options to see how well they work together.
Recruiting
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
PHASE3 Daphne, Alabama +4 sites NCT06492616
This trial is looking for women and men with early breast cancer that has a high risk of coming back. Participants will compare the effects of elacestrant with standard treatment after being on another therapy for a while.
Recruiting
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
PHASE3 Birmingham, Alabama +4 sites NCT05879926
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
A Study Evaluating the Safety of Inavolisib and Fulvestrant With or Without Palbociclib in Participants With Advanced Breast Cancer (ABC) and Type 2 Diabetes
PHASE2 Washington D.C., District of Columbia +4 sites NCT07748208
This trial is looking for people with advanced breast cancer and type 2 diabetes. Participants will take a combination of medications to help evaluate their safety and effectiveness.
Recruiting
TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd
PHASE2 Washington D.C., District of Columbia +4 sites NCT06533826
This trial is looking for women with advanced breast cancer that is HER2-negative. Participants will take part in a treatment involving two investigational drugs to see how effective they are.
Recruiting
Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer
PHASE2 Washington D.C., District of Columbia +4 sites NCT04841148
This trial is looking for women and men with early-stage ER+ breast cancer who have detectable tumor cells in their bone marrow after surgery and treatment. Participants will receive Hydroxychloroquine or Avelumab, possibly combined with Palbociclib, to assess safety and effectiveness.
Recruiting
Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming
NA Washington D.C., District of Columbia NCT06536881
This trial is looking for women with early-stage breast cancer who are planning to receive chemotherapy. Participants will fast for 24-48 hours to see if it helps the treatment work better.
Recruiting
The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer
NA Washington D.C., District of Columbia +3 sites NCT05780814
This trial is looking for women who have survived early stage breast cancer, are overweight, and have insomnia. Participants will receive either a mental health program to improve sleep or sleep education, followed by a program to help with weight loss.
Recruiting
Identifying Patterns in the Breath of Individuals With Breast Cancer
N/A Washington D.C., District of Columbia +4 sites NCT06512350
Recruiting
Circulating Tumor DNA
PHASE2 Washington D.C., District of Columbia +4 sites NCT06923527
This trial is looking for women with ER+ breast cancer who have tested positive for circulating tumor DNA. Participants will receive a treatment called elacestrant and will go through three phases: screening, treatment, and follow-up.
Recruiting
ETHAN - ET for Male BC
PHASE2 Washington D.C., District of Columbia +4 sites NCT05501704
This trial is looking for men with breast cancer who have not had surgery yet. Participants will receive treatment to see how well it works before surgery.
Recruiting
A Study Evaluating Adherence, Tolerability, and Patient Reported Outcomes of Giredestrant in Participants With ER+/HER2- Early Breast Cancer Who Are Intolerant to Adjuvant Aromatase Inhibitor Therapy (novERA Breast Cancer)
PHASE3 Washington D.C., District of Columbia +4 sites NCT07541079
This trial is looking for women with early breast cancer who have had problems with a previous hormonal treatment. If you join, you will switch to taking giredestrant as part of your cancer care.
Recruiting
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT05827081
This trial is looking for adults with early breast cancer that is hormone receptor positive and HER2 negative. If you join, you will receive ribociclib along with standard hormone therapy to see how effective this combination is.
Recruiting
A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer
PHASE1 Washington D.C., District of Columbia +4 sites NCT07310420
This trial is looking for premenopausal women aged 18 to 55 who have been diagnosed with early or advanced hormone receptor positive breast cancer. Participants will receive ZOLADEX to help assess ovarian suppression.
Recruiting
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
PHASE3 Birmingham, Alabama +4 sites NCT04852887
This trial is looking for women with early-stage hormone-sensitive breast cancer who are interested in taking part in a study on surgery and hormone therapy without radiation. Participants will need to meet specific health criteria to join.
Recruiting
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT06058377
This trial is looking for women with hormone receptor positive, HER2 negative stage II-III breast cancer. Participants will receive standard chemotherapy along with an immunotherapy drug called durvalumab to see if it helps prevent cancer from coming back.
Recruiting
A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer
PHASE3 Gilbert, Arizona +4 sites NCT05894239
This trial is looking for people with advanced breast cancer that is HER2-positive and has a specific mutation. Participants will take a combination of medicines after their initial treatment.
Recruiting
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
PHASE3 Birmingham, Alabama +4 sites NCT05633654
This trial is looking for adults with triple negative breast cancer that remains after surgery and treatment. Participants will receive an experimental treatment combining two medications after recovery from surgery.
Recruiting
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
PHASE3 Phoenix, Arizona +4 sites NCT06876714
This trial is looking for adults with HER2-positive breast cancer who have no residual invasive disease after chemotherapy. Participants will receive either 6 or 12 months of HER2-targeted medications to see which duration works best.
Recruiting

Where the Breast Cancer studies are in District of Columbia

  • MedStar Washington Hospital Center, Washington D.C.13 trials
  • MedStar Georgetown University Hospital, Washington D.C.8 trials
  • Sibley Memorial Hospital, Washington D.C.8 trials
  • Georgetown University Medical Center, Washington D.C.7 trials
  • Georgetown University, Washington D.C.4 trials
  • Kaiser Permanente-Capitol Hill Medical Center, Washington D.C.3 trials

Counts are recruiting studies listing at least one site in District of Columbia, from ClinicalTrials.gov, refreshed every two days.

Breast Cancer clinical trials in District of Columbia: common questions

How many Breast Cancer clinical trials are recruiting in District of Columbia?
TrialFinder currently lists 56 recruiting Breast Cancer clinical trials with study sites in District of Columbia. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Breast Cancer clinical trials located in District of Columbia?
Study sites for the Breast Cancer trials listed on this page include Washington D.C.. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Breast Cancer clinical trial in District of Columbia?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Breast Cancer trials in District of Columbia also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Breast Cancer clinical trial in District of Columbia?
Each study sets its own criteria based on age, Breast Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to know my receptor status to join a breast cancer trial?
It helps, because trials are organized by subtype, but the study site reads it from your pathology report. If a trial needs a test you have not had, such as HER2-low or a BRCA result, the site arranges it.
Are there trials for early-stage breast cancer?
Yes. Early-stage trials enroll before surgery, after surgery, or during the years of hormone therapy that follow, and test ways to lower the chance the cancer returns. The listing says which window it enrolls in.
Will a trial replace the treatment my oncologist planned?
Sometimes it is the plan, with a new drug added or compared; sometimes it is an alternative to discuss. Bring the trial page to your oncologist, who can refer you to the site or advise on timing.
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