76 Recruiting Trials

Clinical Trials
for Breast Cancer in Wisconsin

76 clinical trials for Breast Cancer are currently recruiting participants at study sites in Wisconsin. Study-related care is provided at no cost.

76
Recruiting trials
152
Study sites
60
Cities
40
Industry-sponsored
18
Phase 2
28
Phase 3

Breast Cancer clinical trials in Wisconsin: what to expect

Breast cancer trials are sorted first by subtype, because the treatments differ: hormone-receptor-positive, HER2-positive (including the newer HER2-low group) and triple-negative disease each have their own studies. Most recruiting trials test a new drug or combination, including targeted pills, antibody-drug conjugates and immunotherapy, either for metastatic cancer or before and after surgery for early-stage disease. Others study less surgery or radiation, ways to reduce recurrence, and screening for people at higher risk.

In Wisconsin, recruiting breast cancer studies are concentrated in Milwaukee, Madison, Green Bay and Appleton, with sites in 56 other cities. 40 of the 76 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who breast cancer trials usually look for

Listings name the subtype, the stage (early or metastatic) and how many treatments you may already have had. Early-stage trials often enroll between diagnosis and surgery, or in the months after surgery; metastatic trials usually enroll when a treatment has stopped working. Some specify menopausal status or a particular mutation (BRCA, PIK3CA, ESR1), which the site can test for. Nearly all require that you are well enough for daily activity and that recent blood work is adequate.

Your receptor status is on your pathology report; the site will confirm it from that report, so you do not need to know it by heart to ask.

What taking part involves

Screening reviews your pathology and scans and adds blood work, sometimes a biopsy. Treatment then runs in cycles, with infusions every two to three weeks or daily pills, and scans every two to three months to check the response. Early-stage trials follow you for years after treatment ends, usually with a visit or call every few months. Study drugs and study-specific tests are free; care you would receive anyway is billed to insurance as usual. Placebo, when used, is added to standard treatment.

Questions worth asking the study team

How the study treatment compares with what your oncologist would otherwise recommend; whether the trial is randomized and what the other arm receives; what happens if the cancer grows or returns; and how visits fit around work and family. Many trials now allow some visits at a local clinic.

Showing 20 of 76 recruiting Breast Cancer trials in Wisconsin

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
PHASE3 Anchorage, Alaska +4 sites NCT07062965
This trial is looking for people with HR-positive, HER2-negative advanced breast cancer that has worsened after previous treatment. Participants will receive the study medicine PF-07248144 along with their normal treatment options to see how well they work together.
Recruiting
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
PHASE3 Daphne, Alabama +4 sites NCT06103864
This trial is looking for patients with a specific type of breast cancer that is not treatable by surgery. Participants will receive a treatment called Dato-DXd, with or without another drug, or a standard chemotherapy treatment.
Recruiting
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
PHASE3 Hot Springs, Arkansas +4 sites NCT07085767
This trial is looking for adults with advanced breast cancer that hasn’t been treated before. Participants will receive palazestrant with ribociclib or letrozole with ribociclib to see which treatment works better.
Recruiting
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
PHASE3 Daphne, Alabama +4 sites NCT06492616
This trial is looking for women and men with early breast cancer that has a high risk of coming back. Participants will compare the effects of elacestrant with standard treatment after being on another therapy for a while.
Recruiting
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
PHASE3 Birmingham, Alabama +4 sites NCT05879926
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
Recruiting
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
PHASE3 Phoenix, Arizona +4 sites NCT06072612
This trial is looking for adults with advanced or locally recurrent breast cancer who have run out of treatment options. Participants will receive treatment with the Bria-IMT regimen and a checkpoint inhibitor to see how well it works compared to other standard treatments.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
Molecular Analyses to Predict Pathways of Endocrine Resistance Following Short Term Neoadjuvant Endocrine Treatment in Patients With Hormone Receptor-Positive HER2-negative Breast Cancer
PHASE2 Milwaukee, Wisconsin NCT06361940
This trial is looking for women with hormone receptor-positive breast cancer who need treatment before surgery. Participants will receive standard anti-estrogen treatment for 4 to 12 weeks.
Recruiting
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
PHASE2 Anaheim, California +4 sites NCT07405801
This trial is looking for people with advanced breast cancer that has not responded to hormone treatments. Participants will receive a combination of medications to see how effective they are compared to a placebo.
Recruiting
A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
PHASE2 Long Beach, California +4 sites NCT07102381
This trial is looking for people with early-stage HER2-positive breast cancer to see if zanidatamab combined with chemotherapy is safe and effective. Participants will need to undergo surgery after the treatment.
Recruiting
Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers
PHASE2 Madison, Wisconsin +3 sites NCT04886531
This trial is looking for women with certain types of breast cancer who can take part in a new treatment plan. Participants will receive a combination of treatments before their surgery.
Recruiting
Study of 18F-FFNP Breast PET/MRI
PHASE2 Madison, Wisconsin NCT06086704
This trial is looking for postmenopausal women with invasive breast cancer. Participants will take part in imaging tests to see how their cancer responds to treatment before surgery.
Recruiting
Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer
PHASE2 Madison, Wisconsin NCT04573231
This trial is looking for women with a specific type of metastatic breast cancer. Participants will help researchers understand how a certain protein relates to cancer treatment over a period of about 3 days.
Recruiting
Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer
PHASE2 Madison, Wisconsin NCT03936478
This trial is looking for women with early breast cancer who are undergoing a type of surgery called breast-conserving therapy. Participants will receive a new radiation treatment over just one week and will be followed for up to 5 years to see how it works.
Recruiting
Impact of Intermittent Fasting on Biomarkers of Inflammation and Health-Related Quality of Life: A Feasibility Trial for Women With HR+/HER2- Early Breast Cancer
NA Milwaukee, Wisconsin NCT06106477
This trial is looking for women with early breast cancer who want to try intermittent fasting. Participants will fast at night and eat during the day for six months while receiving hormone treatment.
Recruiting
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
N/A Anchorage, Alaska +4 sites NCT06401421
This trial is looking for adults with early, high-risk breast cancer who plan to start chemotherapy. Participants will provide blood and tissue samples for research and will be followed for up to 5.5 years.
Recruiting
Recruiting
FES Imaging to Optimize Tamoxifen for Metastatic Breast Cancer
EARLY_PHASE1 Madison, Wisconsin +1 sites NCT04174352
This trial is looking for people with metastatic breast cancer to find the best dose of the medication tamoxifen. Participation involves undergoing a special imaging test to measure how the cancer responds to the treatment.
Recruiting
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT05827081
This trial is looking for adults with early breast cancer that is hormone receptor positive and HER2 negative. If you join, you will receive ribociclib along with standard hormone therapy to see how effective this combination is.
Recruiting
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
PHASE3 Birmingham, Alabama +4 sites NCT05774951
This trial is looking for people with early breast cancer who have completed at least 2 years of standard treatment. Participants will receive camizestrant to see if it helps improve their outcomes compared to standard therapy.
Recruiting

Where the Breast Cancer studies are in Wisconsin

  • Medical College of Wisconsin, Milwaukee12 trials
  • Aurora BayCare Medical Center, Green Bay10 trials
  • Saint Vincent Hospital Cancer Center Green Bay, Green Bay10 trials
  • Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay10 trials
  • Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan10 trials
  • Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay10 trials

Counts are recruiting studies listing at least one site in Wisconsin, from ClinicalTrials.gov, refreshed every two days.

Breast Cancer clinical trials in Wisconsin: common questions

How many Breast Cancer clinical trials are recruiting in Wisconsin?
TrialFinder currently lists 76 recruiting Breast Cancer clinical trials with study sites in Wisconsin. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Breast Cancer clinical trials located in Wisconsin?
Study sites for the Breast Cancer trials listed on this page include Milwaukee, Madison. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Breast Cancer clinical trial in Wisconsin?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Breast Cancer trials in Wisconsin also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Breast Cancer clinical trial in Wisconsin?
Each study sets its own criteria based on age, Breast Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to know my receptor status to join a breast cancer trial?
It helps, because trials are organized by subtype, but the study site reads it from your pathology report. If a trial needs a test you have not had, such as HER2-low or a BRCA result, the site arranges it.
Are there trials for early-stage breast cancer?
Yes. Early-stage trials enroll before surgery, after surgery, or during the years of hormone therapy that follow, and test ways to lower the chance the cancer returns. The listing says which window it enrolls in.
Will a trial replace the treatment my oncologist planned?
Sometimes it is the plan, with a new drug added or compared; sometimes it is an alternative to discuss. Bring the trial page to your oncologist, who can refer you to the site or advise on timing.
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

Check Your Eligibility

Create a free profile and our AI will match you to Breast Cancer trials near you in Wisconsin.

Get Matched — Free
No insurance required

Breast cancer trials test new chemotherapy regimens, immunotherapy combinations, targeted therapies, and early-detection methods across all stages of breast cancer.

All Breast Cancer trials →