Breast Cancer Trials / Trials in Alabama
58 Recruiting Trials

Clinical Trials
for Breast Cancer in Alabama

58 clinical trials for Breast Cancer are currently recruiting participants at study sites in Alabama. Study-related care is provided at no cost.

58
Recruiting trials
43
Study sites
6
Cities
28
Industry-sponsored
16
Phase 2
16
Phase 3

Breast Cancer clinical trials in Alabama: what to expect

Breast cancer trials are sorted first by subtype, because the treatments differ: hormone-receptor-positive, HER2-positive (including the newer HER2-low group) and triple-negative disease each have their own studies. Most recruiting trials test a new drug or combination, including targeted pills, antibody-drug conjugates and immunotherapy, either for metastatic cancer or before and after surgery for early-stage disease. Others study less surgery or radiation, ways to reduce recurrence, and screening for people at higher risk.

In Alabama, recruiting breast cancer studies are concentrated in Birmingham, Mobile, Huntsville and Daphne, with sites in 2 other cities. 28 of the 58 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who breast cancer trials usually look for

Listings name the subtype, the stage (early or metastatic) and how many treatments you may already have had. Early-stage trials often enroll between diagnosis and surgery, or in the months after surgery; metastatic trials usually enroll when a treatment has stopped working. Some specify menopausal status or a particular mutation (BRCA, PIK3CA, ESR1), which the site can test for. Nearly all require that you are well enough for daily activity and that recent blood work is adequate.

Your receptor status is on your pathology report; the site will confirm it from that report, so you do not need to know it by heart to ask.

What taking part involves

Screening reviews your pathology and scans and adds blood work, sometimes a biopsy. Treatment then runs in cycles, with infusions every two to three weeks or daily pills, and scans every two to three months to check the response. Early-stage trials follow you for years after treatment ends, usually with a visit or call every few months. Study drugs and study-specific tests are free; care you would receive anyway is billed to insurance as usual. Placebo, when used, is added to standard treatment.

Questions worth asking the study team

How the study treatment compares with what your oncologist would otherwise recommend; whether the trial is randomized and what the other arm receives; what happens if the cancer grows or returns; and how visits fit around work and family. Many trials now allow some visits at a local clinic.

Showing 20 of 58 recruiting Breast Cancer trials in Alabama

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
PHASE3 Daphne, Alabama +4 sites NCT06103864
This trial is looking for patients with a specific type of breast cancer that is not treatable by surgery. Participants will receive a treatment called Dato-DXd, with or without another drug, or a standard chemotherapy treatment.
Recruiting
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
PHASE3 Daphne, Alabama +4 sites NCT06492616
This trial is looking for women and men with early breast cancer that has a high risk of coming back. Participants will compare the effects of elacestrant with standard treatment after being on another therapy for a while.
Recruiting
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
PHASE3 Birmingham, Alabama +4 sites NCT05879926
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
Recruiting
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
PHASE1 Huntsville, Alabama +4 sites NCT07100106
This trial is looking for people with advanced breast cancer that is hormone receptor positive and HER2 negative. Participants will receive GDC-4198 by itself or with another drug, Giredestrant, to see how well it works and compare it to another treatment option.
Recruiting
TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd
PHASE2 Birmingham, Alabama +4 sites NCT06533826
This trial is looking for women with advanced breast cancer that is HER2-negative. Participants will take part in a treatment involving two investigational drugs to see how effective they are.
Recruiting
Mind-Body Group Interventions for Psychological Distress in Young Breast Cancer Survivors
NA Birmingham, Alabama +1 sites NCT07501637
This trial is looking for younger women who have survived breast cancer and are experiencing psychological distress. Participants will attend a 3-day virtual workshop and take part in weekly online group sessions for two months.
Recruiting
RAD 1802: Pilot Trial of Five Fraction Stereotactic Body Radiotherapy for Early Stage Breast Cancer Patients Eligible for Post-Operative Accelerated Partial Breast Irradiation (APBI)
NA Birmingham, Alabama +1 sites NCT03643861
This trial is looking for women over 50 with early stage breast cancer who have had a lumpectomy. Participants will receive five sessions of targeted radiation therapy to help prevent cancer from returning.
Recruiting
Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
NA Birmingham, Alabama +4 sites NCT02620852
This trial is looking for women aged 30 to 74 to compare standard breast cancer screening with a plan based on personal risk. Participants can choose their type of care, making it easier for those who may be nervous about being assigned randomly.
Recruiting
Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts
NA Birmingham, Alabama +4 sites NCT05625659
Recruiting
Promoting Resilience in Women With Breast Cancer (PRISM -MBC)
NA Birmingham, Alabama +1 sites NCT06855654
This trial is looking for women and men diagnosed with metastatic breast cancer who want to improve their quality of life through a supportive program. Participants will engage in surveys and counseling sessions remotely to help build resilience during their treatment.
Recruiting
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT05827081
This trial is looking for adults with early breast cancer that is hormone receptor positive and HER2 negative. If you join, you will receive ribociclib along with standard hormone therapy to see how effective this combination is.
Recruiting
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
PHASE3 Birmingham, Alabama +4 sites NCT05774951
This trial is looking for people with early breast cancer who have completed at least 2 years of standard treatment. Participants will receive camizestrant to see if it helps improve their outcomes compared to standard therapy.
Recruiting
BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease
PHASE3 Birmingham, Alabama +4 sites NCT07492641
This trial is looking for people with advanced breast cancer who have not been treated for it before. Participants will receive either BGB-43395 with letrozole or a different treatment option with letrozole.
Recruiting
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
PHASE3 Birmingham, Alabama +4 sites NCT04852887
This trial is looking for women with early-stage hormone-sensitive breast cancer who are interested in taking part in a study on surgery and hormone therapy without radiation. Participants will need to meet specific health criteria to join.
Recruiting
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT06058377
This trial is looking for women with hormone receptor positive, HER2 negative stage II-III breast cancer. Participants will receive standard chemotherapy along with an immunotherapy drug called durvalumab to see if it helps prevent cancer from coming back.
Recruiting
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
PHASE3 Birmingham, Alabama +4 sites NCT05633654
This trial is looking for adults with triple negative breast cancer that remains after surgery and treatment. Participants will receive an experimental treatment combining two medications after recovery from surgery.
Recruiting
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
PHASE3 Mobile, Alabama +4 sites NCT06393374
This trial is looking for adults with a specific type of breast cancer called triple-negative breast cancer who didn’t have a full response to their initial treatment. They need to have recently had surgery and recovered well, and they should not have certain complicated health issues like severe nerve pain or a known genetic mutation linked to breast cancer. Additionally, the trial is not for people who have serious eye problems or are currently pregnant or breastfeeding.
Recruiting
RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive
PHASE2 Huntsville, Alabama +4 sites NCT07413939
This trial is looking for people with locally advanced or metastatic HER2-positive breast cancer. Participants will receive either RO7771950 or tucatinib along with other treatments.
Recruiting
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
PHASE3 Birmingham, Alabama +4 sites NCT05812807
This trial is looking for people with early-stage triple-negative breast cancer who had no cancer left after previous treatments. Participants will either continue receiving pembrolizumab or just be monitored after surgery to see which approach works better to prevent cancer from coming back.
Recruiting
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT05929768
This trial is looking for women with early-stage triple negative breast cancer. Participants will receive a shorter treatment plan involving chemotherapy and immunotherapy without a certain type of drug called anthracyclines.
Recruiting
See all 58 Breast Cancer trials in Alabama

Where the Breast Cancer studies are in Alabama

Research sites running the most studies
  • University of Alabama at Birmingham, Birmingham13 trials
  • University of Alabama at Birmingham Cancer Center, Birmingham6 trials
  • Alabama Oncology, Birmingham3 trials
  • University of South Alabama Mitchell Cancer Institute, Mobile3 trials
  • Clearview Cancer Institute, Huntsville2 trials
  • The Kirklin Clinic, Birmingham2 trials
By city

Counts are recruiting studies listing at least one site in Alabama, from ClinicalTrials.gov, refreshed every two days.

Breast Cancer clinical trials in Alabama: common questions

How many Breast Cancer clinical trials are recruiting in Alabama?
TrialFinder currently lists 58 recruiting Breast Cancer clinical trials with study sites in Alabama. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Breast Cancer clinical trials located in Alabama?
Study sites for the Breast Cancer trials listed on this page include Daphne, Birmingham, Huntsville, Mobile. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Breast Cancer clinical trial in Alabama?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Breast Cancer trials in Alabama also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Breast Cancer clinical trial in Alabama?
Each study sets its own criteria based on age, Breast Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to know my receptor status to join a breast cancer trial?
It helps, because trials are organized by subtype, but the study site reads it from your pathology report. If a trial needs a test you have not had, such as HER2-low or a BRCA result, the site arranges it.
Are there trials for early-stage breast cancer?
Yes. Early-stage trials enroll before surgery, after surgery, or during the years of hormone therapy that follow, and test ways to lower the chance the cancer returns. The listing says which window it enrolls in.
Will a trial replace the treatment my oncologist planned?
Sometimes it is the plan, with a new drug added or compared; sometimes it is an alternative to discuss. Bring the trial page to your oncologist, who can refer you to the site or advise on timing.
Breast Cancer Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Breast Cancer Trials

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