70 Recruiting Trials

Clinical Trials
for Breast Cancer in Indiana

70 clinical trials for Breast Cancer are currently recruiting participants at study sites in Indiana. Study-related care is provided at no cost.

70
Recruiting trials
91
Study sites
24
Cities
38
Industry-sponsored
17
Phase 2
24
Phase 3

Breast Cancer clinical trials in Indiana: what to expect

Breast cancer trials are sorted first by subtype, because the treatments differ: hormone-receptor-positive, HER2-positive (including the newer HER2-low group) and triple-negative disease each have their own studies. Most recruiting trials test a new drug or combination, including targeted pills, antibody-drug conjugates and immunotherapy, either for metastatic cancer or before and after surgery for early-stage disease. Others study less surgery or radiation, ways to reduce recurrence, and screening for people at higher risk.

In Indiana, recruiting breast cancer studies are concentrated in Indianapolis, Fort Wayne, Dyer and Carmel, with sites in 20 other cities. 38 of the 70 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who breast cancer trials usually look for

Listings name the subtype, the stage (early or metastatic) and how many treatments you may already have had. Early-stage trials often enroll between diagnosis and surgery, or in the months after surgery; metastatic trials usually enroll when a treatment has stopped working. Some specify menopausal status or a particular mutation (BRCA, PIK3CA, ESR1), which the site can test for. Nearly all require that you are well enough for daily activity and that recent blood work is adequate.

Your receptor status is on your pathology report; the site will confirm it from that report, so you do not need to know it by heart to ask.

What taking part involves

Screening reviews your pathology and scans and adds blood work, sometimes a biopsy. Treatment then runs in cycles, with infusions every two to three weeks or daily pills, and scans every two to three months to check the response. Early-stage trials follow you for years after treatment ends, usually with a visit or call every few months. Study drugs and study-specific tests are free; care you would receive anyway is billed to insurance as usual. Placebo, when used, is added to standard treatment.

Questions worth asking the study team

How the study treatment compares with what your oncologist would otherwise recommend; whether the trial is randomized and what the other arm receives; what happens if the cancer grows or returns; and how visits fit around work and family. Many trials now allow some visits at a local clinic.

Showing 20 of 70 recruiting Breast Cancer trials in Indiana

A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer
PHASE3 Fort Wayne, Indiana +4 sites NCT07205822
This trial is looking for adults with a specific type of advanced breast cancer. Participants will receive the treatment Dato-DXd and will need to provide a tumor sample and meet certain health requirements.
Recruiting
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
PHASE3 Daphne, Alabama +4 sites NCT06103864
This trial is looking for patients with a specific type of breast cancer that is not treatable by surgery. Participants will receive a treatment called Dato-DXd, with or without another drug, or a standard chemotherapy treatment.
Recruiting
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
PHASE3 Daphne, Alabama +4 sites NCT06492616
This trial is looking for women and men with early breast cancer that has a high risk of coming back. Participants will compare the effects of elacestrant with standard treatment after being on another therapy for a while.
Recruiting
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
PHASE3 Birmingham, Alabama +4 sites NCT05879926
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
Recruiting
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
PHASE3 Phoenix, Arizona +4 sites NCT06072612
This trial is looking for adults with advanced or locally recurrent breast cancer who have run out of treatment options. Participants will receive treatment with the Bria-IMT regimen and a checkpoint inhibitor to see how well it works compared to other standard treatments.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
ATEMPT 2.0: Adjuvant T-DM1 vs TH
PHASE2 San Francisco, California +4 sites NCT04893109
This trial is looking for patients with early-stage breast cancer that tests positive for HER2. Participants will receive one of two treatment options after surgery to see how well they work.
Recruiting
Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer
PHASE2 Indianapolis, Indiana +4 sites NCT04841148
This trial is looking for women and men with early-stage ER+ breast cancer who have detectable tumor cells in their bone marrow after surgery and treatment. Participants will receive Hydroxychloroquine or Avelumab, possibly combined with Palbociclib, to assess safety and effectiveness.
Recruiting
A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer
PHASE2 Tucson, Arizona +4 sites NCT06568692
This trial is looking for patients with advanced breast cancer to test a new treatment combination. Participants will receive either PCS6422 with capecitabine or capecitabine alone.
Recruiting
HER2 Vaccine for Locally Advanced Breast Cancer
PHASE1 Indianapolis, Indiana NCT06949410
This trial is looking for adults with a specific type of breast cancer to test an experimental vaccine. Participants will help researchers understand how the vaccine can activate the immune system to fight the cancer.
Recruiting
Exercise in Metastatic Breast Cancer: EMBody
NA Avon, Indiana +4 sites NCT05468034
This trial is looking for people with metastatic breast cancer who have not seen their disease worsen in the last year. Participants will take part in a 16-week exercise program that includes aerobic and strength training.
Recruiting
NearWave Optical Molecular Monitoring
NA Indianapolis, Indiana NCT06744465
Recruiting
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
N/A Anchorage, Alaska +4 sites NCT06401421
This trial is looking for adults with early, high-risk breast cancer who plan to start chemotherapy. Participants will provide blood and tissue samples for research and will be followed for up to 5.5 years.
Recruiting
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT05827081
This trial is looking for adults with early breast cancer that is hormone receptor positive and HER2 negative. If you join, you will receive ribociclib along with standard hormone therapy to see how effective this combination is.
Recruiting
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
PHASE3 Birmingham, Alabama +4 sites NCT05774951
This trial is looking for people with early breast cancer who have completed at least 2 years of standard treatment. Participants will receive camizestrant to see if it helps improve their outcomes compared to standard therapy.
Recruiting
BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease
PHASE3 Birmingham, Alabama +4 sites NCT07492641
This trial is looking for people with advanced breast cancer who have not been treated for it before. Participants will receive either BGB-43395 with letrozole or a different treatment option with letrozole.
Recruiting
Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
PHASE3 Gilbert, Arizona +4 sites NCT06380751
This trial is looking for adults with certain types of advanced breast cancer. Participants will take either a combination of drugs or a standard treatment chosen by their doctor to see which works better.
Recruiting
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
PHASE3 Birmingham, Alabama +4 sites NCT04852887
This trial is looking for women with early-stage hormone-sensitive breast cancer who are interested in taking part in a study on surgery and hormone therapy without radiation. Participants will need to meet specific health criteria to join.
Recruiting
Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer
PHASE2 Fullerton, California +4 sites NCT04553770
This trial is looking for women with early stage hormone receptor positive breast cancer who have not received prior treatment. Participants will receive either trastuzumab deruxtecan alone or with anastrozole to see how effective the treatment is.
Recruiting

Where the Breast Cancer studies are in Indiana

  • IU Health North Hospital, Carmel7 trials
  • Reid Health, Richmond7 trials
  • IU Health West Hospital, Avon6 trials
  • Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis6 trials
  • UChicago Medicine Northwest Indiana, Crown Point6 trials
  • Franciscan Health Indianapolis, Indianapolis5 trials

Counts are recruiting studies listing at least one site in Indiana, from ClinicalTrials.gov, refreshed every two days.

Breast Cancer clinical trials in Indiana: common questions

How many Breast Cancer clinical trials are recruiting in Indiana?
TrialFinder currently lists 70 recruiting Breast Cancer clinical trials with study sites in Indiana. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Breast Cancer clinical trials located in Indiana?
Study sites for the Breast Cancer trials listed on this page include Fort Wayne, Indianapolis, Avon. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Breast Cancer clinical trial in Indiana?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Breast Cancer trials in Indiana also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Breast Cancer clinical trial in Indiana?
Each study sets its own criteria based on age, Breast Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to know my receptor status to join a breast cancer trial?
It helps, because trials are organized by subtype, but the study site reads it from your pathology report. If a trial needs a test you have not had, such as HER2-low or a BRCA result, the site arranges it.
Are there trials for early-stage breast cancer?
Yes. Early-stage trials enroll before surgery, after surgery, or during the years of hormone therapy that follow, and test ways to lower the chance the cancer returns. The listing says which window it enrolls in.
Will a trial replace the treatment my oncologist planned?
Sometimes it is the plan, with a new drug added or compared; sometimes it is an alternative to discuss. Bring the trial page to your oncologist, who can refer you to the site or advise on timing.
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