30 Recruiting Trials
Clinical Trials
for Breast Cancer in South Dakota
30 clinical trials for Breast Cancer are currently recruiting participants at study sites in South Dakota. Study-related care is provided at no cost.
30
Recruiting trials
29
Study sites
6
Cities
15
Industry-sponsored
5
Phase 2
17
Phase 3
Breast Cancer clinical trials in South Dakota: what to expect
Breast cancer trials are sorted first by subtype, because the treatments differ: hormone-receptor-positive, HER2-positive (including the newer HER2-low group) and triple-negative disease each have their own studies. Most recruiting trials test a new drug or combination, including targeted pills, antibody-drug conjugates and immunotherapy, either for metastatic cancer or before and after surgery for early-stage disease. Others study less surgery or radiation, ways to reduce recurrence, and screening for people at higher risk.
In South Dakota, recruiting breast cancer studies are concentrated in Sioux Falls, Rapid City, Pierre and Yankton, with sites in 2 other cities. 15 of the 30 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who breast cancer trials usually look for
Listings name the subtype, the stage (early or metastatic) and how many treatments you may already have had. Early-stage trials often enroll between diagnosis and surgery, or in the months after surgery; metastatic trials usually enroll when a treatment has stopped working. Some specify menopausal status or a particular mutation (BRCA, PIK3CA, ESR1), which the site can test for. Nearly all require that you are well enough for daily activity and that recent blood work is adequate.
Your receptor status is on your pathology report; the site will confirm it from that report, so you do not need to know it by heart to ask.
What taking part involves
Screening reviews your pathology and scans and adds blood work, sometimes a biopsy. Treatment then runs in cycles, with infusions every two to three weeks or daily pills, and scans every two to three months to check the response. Early-stage trials follow you for years after treatment ends, usually with a visit or call every few months. Study drugs and study-specific tests are free; care you would receive anyway is billed to insurance as usual. Placebo, when used, is added to standard treatment.
Questions worth asking the study team
How the study treatment compares with what your oncologist would otherwise recommend; whether the trial is randomized and what the other arm receives; what happens if the cancer grows or returns; and how visits fit around work and family. Many trials now allow some visits at a local clinic.
Showing 20 of 30 recruiting Breast Cancer trials in South Dakota
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
Recruiting
This trial is looking for women and men with early breast cancer that has a high risk of coming back. Participants will compare the effects of elacestrant with standard treatment after being on another therapy for a while.
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Recruiting
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
E-Mindfulness Approaches for Living After Breast Cancer
Recruiting
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
Recruiting
This trial is looking for people with advanced breast cancer that has not responded to hormone treatments. Participants will receive a combination of medications to see how effective they are compared to a placebo.
Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
Recruiting
This trial is looking for women aged 30 to 74 to compare standard breast cancer screening with a plan based on personal risk. Participants can choose their type of care, making it easier for those who may be nervous about being assigned randomly.
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
Recruiting
This trial is looking for adults with early, high-risk breast cancer who plan to start chemotherapy. Participants will provide blood and tissue samples for research and will be followed for up to 5.5 years.
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
Recruiting
This trial is looking for adults with early breast cancer that is hormone receptor positive and HER2 negative. If you join, you will receive ribociclib along with standard hormone therapy to see how effective this combination is.
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
Recruiting
This trial is looking for people with early breast cancer who have completed at least 2 years of standard treatment. Participants will receive camizestrant to see if it helps improve their outcomes compared to standard therapy.
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
Recruiting
This trial is looking for women with early-stage hormone-sensitive breast cancer who are interested in taking part in a study on surgery and hormone therapy without radiation. Participants will need to meet specific health criteria to join.
Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial
Recruiting
This trial is looking for women who are postmenopausal and have high stage breast cancer that is less likely to come back. Participants will compare hormone therapy and ribociclib to chemotherapy followed by hormone therapy and ribociclib.
A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer
Recruiting
This trial is looking for people with ER-positive, HER2-negative advanced breast cancer who have not received previous treatment. If you join, you will receive a combination of camizestrant and ribociclib until you decide to stop for any reason.
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Recruiting
This trial is looking for adults with triple negative breast cancer that remains after surgery and treatment. Participants will receive an experimental treatment combining two medications after recovery from surgery.
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
Recruiting
This trial is looking for adults with a specific type of breast cancer called triple-negative breast cancer who didn’t have a full response to their initial treatment. They need to have recently had surgery and recovered well, and they should not have certain complicated health issues like severe nerve pain or a known genetic mutation linked to breast cancer. Additionally, the trial is not for people who have serious eye problems or are currently pregnant or breastfeeding.
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
Recruiting
This trial is looking for adults with HER2-positive breast cancer who have no residual invasive disease after chemotherapy. Participants will receive either 6 or 12 months of HER2-targeted medications to see which duration works best.
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Recruiting
This trial is looking for people with early-stage triple-negative breast cancer who had no cancer left after previous treatments. Participants will either continue receiving pembrolizumab or just be monitored after surgery to see which approach works better to prevent cancer from coming back.
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
Recruiting
This trial is looking for women with early-stage triple negative breast cancer. Participants will receive a shorter treatment plan involving chemotherapy and immunotherapy without a certain type of drug called anthracyclines.
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Recruiting
This trial is looking for women with hormone receptor positive, HER2 negative metastatic breast cancer. Participants will be monitored using specific blood tests and imaging to check how well their cancer treatment is working.
A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors
Recruiting
This trial is looking for adults with advanced solid tumors, including cancers like ovarian, breast, and endometrial cancer. Participants will receive a treatment involving Emiltatug Ledadotin and may need to provide tumor tissue for testing.
Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies
Recruiting
This trial is looking for patients with different types of breast cancer who want to help researchers find out if a simple blood test can detect leftover cancer cells. Participants will need to provide blood samples and other information about their cancer treatment.
Where the Breast Cancer studies are in South Dakota
Research sites running the most studies
- Sanford Cancer Center Oncology Clinic, Sioux Falls11 trials
- Sanford USD Medical Center - Sioux Falls, Sioux Falls11 trials
- Avera Cancer Institute, Sioux Falls10 trials
- Rapid City Regional Hospital, Rapid City6 trials
- Avera Cancer Institute - Mitchell, Mitchell4 trials
- Avera Cancer Institute - Aberdeen, Aberdeen2 trials
By city
Counts are recruiting studies listing at least one site in South Dakota, from ClinicalTrials.gov, refreshed every two days.
Breast Cancer clinical trials in South Dakota: common questions
How many Breast Cancer clinical trials are recruiting in South Dakota?
TrialFinder currently lists 30 recruiting Breast Cancer clinical trials with study sites in South Dakota. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Breast Cancer clinical trials located in South Dakota?
Study sites for the Breast Cancer trials listed on this page include Aberdeen. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Breast Cancer clinical trial in South Dakota?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Breast Cancer trials in South Dakota also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Breast Cancer clinical trial in South Dakota?
Each study sets its own criteria based on age, Breast Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to know my receptor status to join a breast cancer trial?
It helps, because trials are organized by subtype, but the study site reads it from your pathology report. If a trial needs a test you have not had, such as HER2-low or a BRCA result, the site arranges it.
Are there trials for early-stage breast cancer?
Yes. Early-stage trials enroll before surgery, after surgery, or during the years of hormone therapy that follow, and test ways to lower the chance the cancer returns. The listing says which window it enrolls in.
Will a trial replace the treatment my oncologist planned?
Sometimes it is the plan, with a new drug added or compared; sometimes it is an alternative to discuss. Bring the trial page to your oncologist, who can refer you to the site or advise on timing.
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Breast Cancer Trials
Breast cancer trials test new chemotherapy regimens, immunotherapy combinations, targeted therapies, and early-detection methods across all stages of breast cancer.
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