11 Recruiting Trials

Clinical Trials
for Breast Cancer in Vermont

11 clinical trials for Breast Cancer are currently recruiting participants at study sites in Vermont. Study-related care is provided at no cost.

11
Recruiting trials
6
Study sites
3
Cities
3
Industry-sponsored
1
Phase 2
8
Phase 3

Breast Cancer clinical trials in Vermont: what to expect

Breast cancer trials are sorted first by subtype, because the treatments differ: hormone-receptor-positive, HER2-positive (including the newer HER2-low group) and triple-negative disease each have their own studies. Most recruiting trials test a new drug or combination, including targeted pills, antibody-drug conjugates and immunotherapy, either for metastatic cancer or before and after surgery for early-stage disease. Others study less surgery or radiation, ways to reduce recurrence, and screening for people at higher risk.

In Vermont, recruiting breast cancer studies are concentrated in Burlington, Berlin Corners and Saint Johnsbury. 3 of the 11 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who breast cancer trials usually look for

Listings name the subtype, the stage (early or metastatic) and how many treatments you may already have had. Early-stage trials often enroll between diagnosis and surgery, or in the months after surgery; metastatic trials usually enroll when a treatment has stopped working. Some specify menopausal status or a particular mutation (BRCA, PIK3CA, ESR1), which the site can test for. Nearly all require that you are well enough for daily activity and that recent blood work is adequate.

Your receptor status is on your pathology report; the site will confirm it from that report, so you do not need to know it by heart to ask.

What taking part involves

Screening reviews your pathology and scans and adds blood work, sometimes a biopsy. Treatment then runs in cycles, with infusions every two to three weeks or daily pills, and scans every two to three months to check the response. Early-stage trials follow you for years after treatment ends, usually with a visit or call every few months. Study drugs and study-specific tests are free; care you would receive anyway is billed to insurance as usual. Placebo, when used, is added to standard treatment.

Questions worth asking the study team

How the study treatment compares with what your oncologist would otherwise recommend; whether the trial is randomized and what the other arm receives; what happens if the cancer grows or returns; and how visits fit around work and family. Many trials now allow some visits at a local clinic.

Showing 11 of 11 recruiting Breast Cancer trials in Vermont

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
PHASE3 Daphne, Alabama +4 sites NCT06492616
This trial is looking for women and men with early breast cancer that has a high risk of coming back. Participants will compare the effects of elacestrant with standard treatment after being on another therapy for a while.
Recruiting
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
PHASE3 Birmingham, Alabama +4 sites NCT05879926
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
Recruiting
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
PHASE3 Birmingham, Alabama +4 sites NCT04852887
This trial is looking for women with early-stage hormone-sensitive breast cancer who are interested in taking part in a study on surgery and hormone therapy without radiation. Participants will need to meet specific health criteria to join.
Recruiting
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
PHASE3 Phoenix, Arizona +4 sites NCT06876714
This trial is looking for adults with HER2-positive breast cancer who have no residual invasive disease after chemotherapy. Participants will receive either 6 or 12 months of HER2-targeted medications to see which duration works best.
Recruiting
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
PHASE3 Birmingham, Alabama +4 sites NCT05812807
This trial is looking for people with early-stage triple-negative breast cancer who had no cancer left after previous treatments. Participants will either continue receiving pembrolizumab or just be monitored after surgery to see which approach works better to prevent cancer from coming back.
Recruiting
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT05929768
This trial is looking for women with early-stage triple negative breast cancer. Participants will receive a shorter treatment plan involving chemotherapy and immunotherapy without a certain type of drug called anthracyclines.
Recruiting
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
PHASE3 Anchorage, Alaska +4 sites NCT07174336
This trial is looking for people with advanced breast cancer that has a specific genetic change. Participants will receive Tersolisib along with other cancer treatments, and they can continue as long as the treatment is effective and manageable.
Recruiting
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
PHASE2 Birmingham, Alabama +4 sites NCT07287098
This trial is looking for premenopausal women with a specific type of early breast cancer. Participants will take a treatment called imlunestrant for either 29 days or up to 6 months, depending on the group they join.
Recruiting
DOAC - Dosing Options in AntiCoagulation Prophylaxis
PHASE3 Burlington, Vermont NCT07005024
This trial is looking for people with cancer who are starting or changing treatment. Participants will take a specific blood thinner for 6 months to see if it helps prevent blood clots.
Recruiting
Expanding the Support of Family Caregivers of Diverse Patients With Cancer and Diabetes
NA Burlington, Vermont +2 sites NCT07061652
This trial is looking for caregivers of adults with cancer and diabetes to participate in a support program. Participants will help improve support services for caregivers through a coaching program.
Recruiting
Care Coordination Educational Intervention Study for Patients From Rural Areas With Early Stage Cancer
NA Burlington, Vermont NCT05723250
This trial is looking for patients with early stage breast, lung, or colon cancer who live in rural Vermont. Participants will receive a video to help them understand their cancer care and will share their thoughts on coordination of care before and after four to six months.
Recruiting

Where the Breast Cancer studies are in Vermont

  • University of Vermont Medical Center, Burlington7 trials
  • University of Vermont and State Agricultural College, Burlington5 trials
  • Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners4 trials
  • Dartmouth Cancer Center - North, Saint Johnsbury3 trials
  • The University of Vermont Medical Center Inc., Burlington2 trials
  • University of Vermont Cancer Center, Burlington2 trials

Counts are recruiting studies listing at least one site in Vermont, from ClinicalTrials.gov, refreshed every two days.

Breast Cancer clinical trials in Vermont: common questions

How many Breast Cancer clinical trials are recruiting in Vermont?
TrialFinder currently lists 11 recruiting Breast Cancer clinical trials with study sites in Vermont. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Breast Cancer clinical trials located in Vermont?
Study sites for the Breast Cancer trials listed on this page include Burlington. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Breast Cancer clinical trial in Vermont?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Breast Cancer trials in Vermont also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Breast Cancer clinical trial in Vermont?
Each study sets its own criteria based on age, Breast Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to know my receptor status to join a breast cancer trial?
It helps, because trials are organized by subtype, but the study site reads it from your pathology report. If a trial needs a test you have not had, such as HER2-low or a BRCA result, the site arranges it.
Are there trials for early-stage breast cancer?
Yes. Early-stage trials enroll before surgery, after surgery, or during the years of hormone therapy that follow, and test ways to lower the chance the cancer returns. The listing says which window it enrolls in.
Will a trial replace the treatment my oncologist planned?
Sometimes it is the plan, with a new drug added or compared; sometimes it is an alternative to discuss. Bring the trial page to your oncologist, who can refer you to the site or advise on timing.
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