64 Recruiting Trials

Clinical Trials
for Cancer in Vermont

64 clinical trials for Cancer are currently recruiting participants at study sites in Vermont. Study-related care is provided at no cost.

64
Recruiting trials
12
Study sites
4
Cities
8
Industry-sponsored
26
Phase 2
35
Phase 3

Cancer clinical trials in Vermont: what to expect

Cancer is the single largest area of clinical research, and nearly every recruiting cancer trial is written for one cancer type at one stage. Most test a new drug or combination against the current standard treatment: targeted medicines matched to a mutation found in the tumor, immunotherapies that help the immune system recognize cancer cells, antibody-drug conjugates and cell therapies. Others study surgery and radiation techniques, ways to reduce side effects, and screening or prevention in people at higher risk.

In Vermont, recruiting cancer studies are concentrated in Burlington, Saint Johnsbury, Berlin Corners and White River Junction. 8 of the 64 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who cancer trials usually look for

Every listing names the cancer type and stage it enrolls, and most also state how many earlier treatments you may have had: some are for people newly diagnosed, many are for cancer that has come back or spread after a first treatment stopped working. Targeted-therapy trials require a specific result on tumor testing, which the site can arrange if it has not been done. Trials generally ask that you are well enough for daily activity (a "performance status" the doctor scores), that blood counts and liver and kidney function are adequate, and that a few weeks have passed since your last treatment.

Having advanced or metastatic cancer does not rule you out. A large share of recruiting trials are designed specifically for it.

What taking part involves

Screening reviews your pathology and scans, often with new blood work and sometimes a fresh biopsy. Treatment then follows a cycle, typically every two or three weeks, with scans every six to twelve weeks to measure the response. Early-phase trials have more frequent visits at the start. The study drug and study-specific tests are provided at no cost; standard care that you would receive anyway is usually billed to insurance as normal. A placebo on its own is rare in cancer trials: when there is one, it is added to the standard treatment, and the consent form says so.

Questions worth asking the study team

Whether the trial is randomized and what the comparison treatment is; what happens if the cancer grows during the study; whether you can keep receiving the drug afterward if it is working; how the trial fits with the plan your own oncologist has suggested; and what travel or lodging support is offered. Your oncologist can also refer you directly.

Showing 20 of 64 recruiting Cancer trials in Vermont

DOAC - Dosing Options in AntiCoagulation Prophylaxis
PHASE3 Burlington, Vermont NCT07005024
This trial is looking for people with cancer who are starting or changing treatment. Participants will take a specific blood thinner for 6 months to see if it helps prevent blood clots.
Recruiting
Expanding the Support of Family Caregivers of Diverse Patients With Cancer and Diabetes
NA Burlington, Vermont +2 sites NCT07061652
This trial is looking for caregivers of adults with cancer and diabetes to participate in a support program. Participants will help improve support services for caregivers through a coaching program.
Recruiting
Care Coordination Educational Intervention Study for Patients From Rural Areas With Early Stage Cancer
NA Burlington, Vermont NCT05723250
This trial is looking for patients with early stage breast, lung, or colon cancer who live in rural Vermont. Participants will receive a video to help them understand their cancer care and will share their thoughts on coordination of care before and after four to six months.
Recruiting
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
PHASE3 Mobile, Alabama +4 sites NCT07228832
This trial is looking for patients with metastatic colorectal cancer who have not received any previous treatment. Participants will receive either Ivonescimab or Bevacizumab combined with chemotherapy as their first treatment.
Recruiting
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
PHASE3 Phoenix, Arizona +4 sites NCT06876714
This trial is looking for adults with HER2-positive breast cancer who have no residual invasive disease after chemotherapy. Participants will receive either 6 or 12 months of HER2-targeted medications to see which duration works best.
Recruiting
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
PHASE3 Daphne, Alabama +4 sites NCT06492616
This trial is looking for women and men with early breast cancer that has a high risk of coming back. Participants will compare the effects of elacestrant with standard treatment after being on another therapy for a while.
Recruiting
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
PHASE3 Birmingham, Alabama +4 sites NCT05879926
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
Recruiting
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
PHASE3 Birmingham, Alabama +4 sites NCT05812807
This trial is looking for people with early-stage triple-negative breast cancer who had no cancer left after previous treatments. Participants will either continue receiving pembrolizumab or just be monitored after surgery to see which approach works better to prevent cancer from coming back.
Recruiting
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
PHASE3 Corona, California +4 sites NCT05451004
This trial is looking for people with oropharyngeal cancer that affects one side of the neck. Participants will receive specialized radiotherapy treatment guided by imaging to see if this improves outcomes compared to standard treatment.
Recruiting
Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06205485
This trial is looking for people with rectal cancer to compare two treatment options. Participants will receive either chemotherapy alone or chemotherapy with radiation before surgery.
Recruiting
Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response
PHASE3 Anchorage, Alaska +4 sites NCT06592924
This trial is looking for men with prostate cancer that has spread and is responding poorly to current treatment. Participants will receive additional medication to see if it helps lower cancer growth and spread.
Recruiting
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
PHASE2 Birmingham, Alabama +4 sites NCT03851445
This trial is looking for patients with previously treated non-small cell lung cancer. Participants will undergo testing and may receive new therapies that target cancer growth compared to standard treatments.
Recruiting
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
PHASE3 Birmingham, Alabama +4 sites NCT04852887
This trial is looking for women with early-stage hormone-sensitive breast cancer who are interested in taking part in a study on surgery and hormone therapy without radiation. Participants will need to meet specific health criteria to join.
Recruiting
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT05929768
This trial is looking for women with early-stage triple negative breast cancer. Participants will receive a shorter treatment plan involving chemotherapy and immunotherapy without a certain type of drug called anthracyclines.
Recruiting
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
PHASE2 Anchorage, Alaska +4 sites NCT05640999
This trial is looking for patients with early-stage endometrial cancer who have had surgery. Participants will receive a less intense treatment to see how it works for their specific cancer type.
Recruiting
Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance
PHASE2 West Haven, Connecticut +4 sites NCT05796375
This trial is looking for adults with a history of low-grade non-muscle invasive bladder cancer. Participants will help researchers see if urine tests can replace some bladder checks that are usually done with a scope.
Recruiting
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
PHASE2 Birmingham, Alabama +4 sites NCT05174169
This trial is looking for patients with Stage III colon cancer who have had surgery. Participants will receive chemotherapy based on the presence of certain markers in their blood after their surgery.
Recruiting
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
PHASE3 Anchorage, Alaska +4 sites NCT04267848
This trial is looking for adults who have had surgery for certain stages of non-small cell lung cancer. Participants will receive a type of drug called pembrolizumab along with their usual chemotherapy treatment to help improve their chances of survival.
Recruiting
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
PHASE2 Little Rock, Arkansas +4 sites NCT06203600
This trial is looking for people with advanced stomach or esophageal cancer. Participants will receive a combination of treatments including nivolumab alongside their usual medications to see if it improves treatment results.
Recruiting
Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
PHASE3 Little Rock, Arkansas +4 sites NCT06589804
This trial is looking for patients with certain types of head and neck cancer that have returned or spread. Participants will receive a combination of two medications, cetuximab and pembrolizumab, and will be monitored for effectiveness and safety.
Recruiting

Where the Cancer studies are in Vermont

  • University of Vermont Medical Center, Burlington36 trials
  • University of Vermont and State Agricultural College, Burlington27 trials
  • Dartmouth Cancer Center - North, Saint Johnsbury24 trials
  • Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners21 trials
  • The University of Vermont Medical Center Inc., Burlington4 trials
  • White River Junction Veteran Administration Medical Center, White River Junction3 trials

Counts are recruiting studies listing at least one site in Vermont, from ClinicalTrials.gov, refreshed every two days.

Cancer clinical trials in Vermont: common questions

How many Cancer clinical trials are recruiting in Vermont?
TrialFinder currently lists 64 recruiting Cancer clinical trials with study sites in Vermont. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Cancer clinical trials located in Vermont?
Study sites for the Cancer trials listed on this page include Burlington. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Cancer clinical trial in Vermont?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Cancer trials in Vermont also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Cancer clinical trial in Vermont?
Each study sets its own criteria based on age, Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I get a placebo instead of cancer treatment?
Almost never. Cancer trials compare a new treatment with the current standard treatment, or add the study drug to standard treatment. When a placebo is used it is on top of standard care, and the consent form states this before you decide.
Can I join a cancer trial if my cancer has spread?
Yes. Many recruiting cancer trials are written for advanced or metastatic disease, including people whose earlier treatments have stopped working. The listing states the stage and prior treatments it accepts.
Do I have to stop my current cancer treatment to join a trial?
It depends on the trial. Some enroll people whose current treatment has stopped working, some add the study drug to the treatment you are on, and some are for people who have not started treatment yet. Ask the study team before changing anything.
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