Breast Cancer Trials / Trials in Delaware
18 Recruiting Trials

Clinical Trials
for Breast Cancer in Delaware

18 clinical trials for Breast Cancer are currently recruiting participants at study sites in Delaware. Study-related care is provided at no cost.

18
Recruiting trials
22
Study sites
9
Cities
8
Industry-sponsored
3
Phase 2
12
Phase 3

Breast Cancer clinical trials in Delaware: what to expect

Breast cancer trials are sorted first by subtype, because the treatments differ: hormone-receptor-positive, HER2-positive (including the newer HER2-low group) and triple-negative disease each have their own studies. Most recruiting trials test a new drug or combination, including targeted pills, antibody-drug conjugates and immunotherapy, either for metastatic cancer or before and after surgery for early-stage disease. Others study less surgery or radiation, ways to reduce recurrence, and screening for people at higher risk.

In Delaware, recruiting breast cancer studies are concentrated in Newark, Rehoboth Beach, Millville and Lewes, with sites in 5 other cities. 8 of the 18 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who breast cancer trials usually look for

Listings name the subtype, the stage (early or metastatic) and how many treatments you may already have had. Early-stage trials often enroll between diagnosis and surgery, or in the months after surgery; metastatic trials usually enroll when a treatment has stopped working. Some specify menopausal status or a particular mutation (BRCA, PIK3CA, ESR1), which the site can test for. Nearly all require that you are well enough for daily activity and that recent blood work is adequate.

Your receptor status is on your pathology report; the site will confirm it from that report, so you do not need to know it by heart to ask.

What taking part involves

Screening reviews your pathology and scans and adds blood work, sometimes a biopsy. Treatment then runs in cycles, with infusions every two to three weeks or daily pills, and scans every two to three months to check the response. Early-stage trials follow you for years after treatment ends, usually with a visit or call every few months. Study drugs and study-specific tests are free; care you would receive anyway is billed to insurance as usual. Placebo, when used, is added to standard treatment.

Questions worth asking the study team

How the study treatment compares with what your oncologist would otherwise recommend; whether the trial is randomized and what the other arm receives; what happens if the cancer grows or returns; and how visits fit around work and family. Many trials now allow some visits at a local clinic.

Showing 18 of 18 recruiting Breast Cancer trials in Delaware

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
PHASE3 Birmingham, Alabama +4 sites NCT05879926
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
Recruiting
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
PHASE3 Birmingham, Alabama +4 sites NCT04852887
This trial is looking for women with early-stage hormone-sensitive breast cancer who are interested in taking part in a study on surgery and hormone therapy without radiation. Participants will need to meet specific health criteria to join.
Recruiting
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT06058377
This trial is looking for women with hormone receptor positive, HER2 negative stage II-III breast cancer. Participants will receive standard chemotherapy along with an immunotherapy drug called durvalumab to see if it helps prevent cancer from coming back.
Recruiting
Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial
PHASE3 Jonesboro, Arkansas +4 sites NCT07391774
This trial is looking for women who are postmenopausal and have high stage breast cancer that is less likely to come back. Participants will compare hormone therapy and ribociclib to chemotherapy followed by hormone therapy and ribociclib.
Recruiting
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
PHASE3 Mobile, Alabama +4 sites NCT06393374
This trial is looking for adults with a specific type of breast cancer called triple-negative breast cancer who didn’t have a full response to their initial treatment. They need to have recently had surgery and recovered well, and they should not have certain complicated health issues like severe nerve pain or a known genetic mutation linked to breast cancer. Additionally, the trial is not for people who have serious eye problems or are currently pregnant or breastfeeding.
Recruiting
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
PHASE3 Phoenix, Arizona +4 sites NCT06876714
This trial is looking for adults with HER2-positive breast cancer who have no residual invasive disease after chemotherapy. Participants will receive either 6 or 12 months of HER2-targeted medications to see which duration works best.
Recruiting
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
PHASE3 Birmingham, Alabama +4 sites NCT05812807
This trial is looking for people with early-stage triple-negative breast cancer who had no cancer left after previous treatments. Participants will either continue receiving pembrolizumab or just be monitored after surgery to see which approach works better to prevent cancer from coming back.
Recruiting
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
PHASE3 Birmingham, Alabama +4 sites NCT05929768
This trial is looking for women with early-stage triple negative breast cancer. Participants will receive a shorter treatment plan involving chemotherapy and immunotherapy without a certain type of drug called anthracyclines.
Recruiting
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
N/A Birmingham, Alabama +4 sites NCT03053193
This trial is looking for patients with stage I to III breast cancer who are receiving MammaPrint® and BluePrint testing. By joining, you will help researchers gather more information and possibly open up more study options in the future.
Recruiting
Bundled Cancer Screening and Genetic Services Navigation
NA Newark, Delaware +1 sites NCT07228000
This trial is looking for women aged 45-74 who identify as Black/African American or Hispanic/Latin(e)(a) and are interested in breast and colon cancer screening. Participants will receive help with navigating these screenings and may be asked to complete surveys during the study.
Recruiting
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer
PHASE3 Gilbert, Arizona +4 sites NCT06982521
This trial is looking for adults with a specific type of breast cancer that has progressed after previous treatments. Participants will receive one of two treatment combinations and will be monitored for safety and effectiveness.
Recruiting
S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity
PHASE3 Anchorage, Alaska +4 sites NCT03418961
This trial is looking for patients with breast cancer that has spread to other parts of the body. Participants must be receiving trastuzumab-based treatment and will be monitored for potential heart problems.
Recruiting
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
PHASE3 Daphne, Alabama +4 sites NCT07060807
This trial is looking for women with certain types of breast cancer that cannot be removed by surgery or have spread to other parts of the body. Participants will receive a treatment called patritumab deruxtecan to see if it helps them live longer or stop cancer from growing.
Recruiting
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
PHASE2 Hot Springs, Arkansas +4 sites NCT06926868
This trial is looking for adults with advanced triple-negative breast cancer who cannot receive certain other therapies. Participants will receive either a new treatment called Izalontamab or standard chemotherapy. Their health and response to treatment will be monitored throughout the study.
Recruiting
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
PHASE1 Irvine, California +4 sites NCT04585750
This trial is looking for adults and some teens with advanced solid tumors that have a specific gene mutation. Participants will take the medication PC14586 and will be monitored for safety and effectiveness.
Recruiting
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
N/A Birmingham, Alabama +4 sites NCT03452774
This trial is looking for cancer patients to see if an AI tool can help match them to clinical trials. Patients will have their cancer-related biomarkers evaluated to find suitable studies for their condition.
Recruiting
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
PHASE2 Birmingham, Alabama +4 sites NCT05564377
This trial is looking for patients with advanced solid tumors that have either spread to nearby areas or other parts of the body and who have not improved with standard treatments. Participating involves having genetic testing and possibly a biopsy to help find a suitable treatment that targets specific genetic changes in the tumor.
Recruiting
A Prospective Registry to Enable Collection of Standardized Routine Care Oncology Patient Data
N/A Dover, Delaware +4 sites NCT06877884
This trial is looking for cancer patients at participating oncology centers. If you join, your treatment and outcomes will be recorded to help improve research and future clinical trials.
Recruiting
See all 18 Breast Cancer trials in Delaware

Where the Breast Cancer studies are in Delaware

Research sites running the most studies
  • Helen F Graham Cancer Center, Newark9 trials
  • Medical Oncology Hematology Consultants PA, Newark9 trials
  • Beebe Health Campus, Rehoboth Beach8 trials
  • Beebe South Coastal Health Campus, Millville7 trials
  • Beebe Medical Center, Lewes5 trials
  • Christiana Care Health System-Christiana Hospital, Newark5 trials
By city

Counts are recruiting studies listing at least one site in Delaware, from ClinicalTrials.gov, refreshed every two days.

Breast Cancer clinical trials in Delaware: common questions

How many Breast Cancer clinical trials are recruiting in Delaware?
TrialFinder currently lists 18 recruiting Breast Cancer clinical trials with study sites in Delaware. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Breast Cancer clinical trials located in Delaware?
Study sites for the Breast Cancer trials listed on this page include Newark, Dover. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Breast Cancer clinical trial in Delaware?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Breast Cancer trials in Delaware also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Breast Cancer clinical trial in Delaware?
Each study sets its own criteria based on age, Breast Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to know my receptor status to join a breast cancer trial?
It helps, because trials are organized by subtype, but the study site reads it from your pathology report. If a trial needs a test you have not had, such as HER2-low or a BRCA result, the site arranges it.
Are there trials for early-stage breast cancer?
Yes. Early-stage trials enroll before surgery, after surgery, or during the years of hormone therapy that follow, and test ways to lower the chance the cancer returns. The listing says which window it enrolls in.
Will a trial replace the treatment my oncologist planned?
Sometimes it is the plan, with a new drug added or compared; sometimes it is an alternative to discuss. Bring the trial page to your oncologist, who can refer you to the site or advise on timing.
Breast Cancer Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Breast Cancer Trials

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