Breast Cancer Trials / Trials in North Carolina
156 Recruiting Trials

Clinical Trials
for Breast Cancer in North Carolina

156 clinical trials for Breast Cancer are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.

156
Recruiting trials
189
Study sites
52
Cities
59
Industry-sponsored
42
Phase 2
31
Phase 3

Breast Cancer clinical trials in North Carolina: what to expect

Breast cancer trials are sorted first by subtype, because the treatments differ: hormone-receptor-positive, HER2-positive (including the newer HER2-low group) and triple-negative disease each have their own studies. Most recruiting trials test a new drug or combination, including targeted pills, antibody-drug conjugates and immunotherapy, either for metastatic cancer or before and after surgery for early-stage disease. Others study less surgery or radiation, ways to reduce recurrence, and screening for people at higher risk.

In North Carolina, recruiting breast cancer studies are concentrated in Durham, Chapel Hill, Charlotte and Winston-Salem, with sites in 48 other cities. 59 of the 156 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who breast cancer trials usually look for

Listings name the subtype, the stage (early or metastatic) and how many treatments you may already have had. Early-stage trials often enroll between diagnosis and surgery, or in the months after surgery; metastatic trials usually enroll when a treatment has stopped working. Some specify menopausal status or a particular mutation (BRCA, PIK3CA, ESR1), which the site can test for. Nearly all require that you are well enough for daily activity and that recent blood work is adequate.

Your receptor status is on your pathology report; the site will confirm it from that report, so you do not need to know it by heart to ask.

What taking part involves

Screening reviews your pathology and scans and adds blood work, sometimes a biopsy. Treatment then runs in cycles, with infusions every two to three weeks or daily pills, and scans every two to three months to check the response. Early-stage trials follow you for years after treatment ends, usually with a visit or call every few months. Study drugs and study-specific tests are free; care you would receive anyway is billed to insurance as usual. Placebo, when used, is added to standard treatment.

Questions worth asking the study team

How the study treatment compares with what your oncologist would otherwise recommend; whether the trial is randomized and what the other arm receives; what happens if the cancer grows or returns; and how visits fit around work and family. Many trials now allow some visits at a local clinic.

Showing 20 of 156 recruiting Breast Cancer trials in North Carolina

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
PHASE3 Anchorage, Alaska +4 sites NCT07062965
This trial is looking for people with HR-positive, HER2-negative advanced breast cancer that has worsened after previous treatment. Participants will receive the study medicine PF-07248144 along with their normal treatment options to see how well they work together.
Recruiting
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
PHASE3 Goodyear, Arizona +4 sites NCT06790693
This trial is looking for adults with a specific type of advanced breast cancer to test a new treatment combo. Participants will receive either the new treatment or a placebo along with standard care.
Recruiting
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
PHASE3 Greenbrae, California +4 sites NCT05646862
This trial is looking for people with advanced breast cancer that has specific mutations and has not improved after certain treatments. Participants will compare two treatment combinations to see which is more effective and safe.
Recruiting
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
PHASE3 Hot Springs, Arkansas +4 sites NCT07085767
This trial is looking for adults with advanced breast cancer that hasn’t been treated before. Participants will receive palazestrant with ribociclib or letrozole with ribociclib to see which treatment works better.
Recruiting
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
PHASE3 Daphne, Alabama +4 sites NCT06492616
This trial is looking for women and men with early breast cancer that has a high risk of coming back. Participants will compare the effects of elacestrant with standard treatment after being on another therapy for a while.
Recruiting
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
PHASE3 Birmingham, Alabama +4 sites NCT05879926
This trial is looking for premenopausal women with early-stage breast cancer that is hormone receptor-positive. Participants will receive hormone therapy and may also get chemotherapy to see if it helps them live longer without cancer returning.
Recruiting
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
PHASE3 Phoenix, Arizona +4 sites NCT06072612
This trial is looking for adults with advanced or locally recurrent breast cancer who have run out of treatment options. Participants will receive treatment with the Bria-IMT regimen and a checkpoint inhibitor to see how well it works compared to other standard treatments.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
PHASE1 Huntsville, Alabama +4 sites NCT07100106
This trial is looking for people with advanced breast cancer that is hormone receptor positive and HER2 negative. Participants will receive GDC-4198 by itself or with another drug, Giredestrant, to see how well it works and compare it to another treatment option.
Recruiting
A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
PHASE2 Long Beach, California +4 sites NCT07102381
This trial is looking for people with early-stage HER2-positive breast cancer to see if zanidatamab combined with chemotherapy is safe and effective. Participants will need to undergo surgery after the treatment.
Recruiting
Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)
PHASE2 Chapel Hill, North Carolina NCT06902311
This trial is looking for women aged 50 and older who have early-stage breast cancer or ductal carcinoma in situ. Participants will receive a specific type of radiation treatment aimed at minimizing the number of visits to the clinic while still being effective.
Recruiting
TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd
PHASE2 Birmingham, Alabama +4 sites NCT06533826
This trial is looking for women with advanced breast cancer that is HER2-negative. Participants will take part in a treatment involving two investigational drugs to see how effective they are.
Recruiting
ATEMPT 2.0: Adjuvant T-DM1 vs TH
PHASE2 San Francisco, California +4 sites NCT04893109
This trial is looking for patients with early-stage breast cancer that tests positive for HER2. Participants will receive one of two treatment options after surgery to see how well they work.
Recruiting
DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs
PHASE2 Durham, North Carolina +2 sites NCT06176261
This trial is looking for adults with breast cancer that has spread to the brain. Participants will take a study drug called datopotamab deruxtecan and undergo imaging tests to confirm their condition.
Recruiting
Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy
PHASE2 Chapel Hill, North Carolina NCT05472792
This trial is looking for women aged 65 and older who have been diagnosed with low-risk breast cancer. Participants will receive either radiation therapy or hormonal therapy after their surgery and will help researchers compare the effects on quality of life.
Recruiting
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
PHASE2 Chapel Hill, North Carolina NCT06727773
This trial is looking for women with stage I-III breast cancer who are receiving chemotherapy. Participants will take memantine or a placebo, and also take part in an exercise program to see if it helps improve thinking skills during treatment.
Recruiting
Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC
PHASE2 Stamford, Connecticut +4 sites NCT04468061
This trial is looking for adults with advanced triple-negative breast cancer that has spread and is PD-L1-negative. Participants will receive either sacituzumab govitecan or pembrolizumab, and may need to undergo biopsies during the trial.
Recruiting
Preoperative Chemotherapy, Pembrolizumab and Low or High Dose RADiation in an Expansion Cohort of Node(+), Triple Negative Breast Cancer
PHASE2 Chapel Hill, North Carolina NCT07276880
This trial is looking for adults with operable triple negative breast cancer that has spread to lymph nodes. Participants will receive a combination of chemotherapy, immunotherapy, and radiation therapy as part of their treatment.
Recruiting
Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells
PHASE1 Chapel Hill, North Carolina NCT06347068
This trial is looking for people with relapsed or resistant triple-negative breast cancer. Participants will receive increasing doses of a special type of immune cell therapy called CAR-T cells.
Recruiting
Weight Management After Cancer for Survivors in Rural Communities
NA Durham, North Carolina +4 sites NCT07426952
This trial is looking for women aged 18 and older who have survived stage I-III breast cancer. Participants will join a program to help manage weight and health through online sessions and health check-ups.
Recruiting
See all 156 Breast Cancer trials in North Carolina

Where the Breast Cancer studies are in North Carolina

Research sites running the most studies
  • Duke Cancer Institute, Durham18 trials
  • University of North Carolina, Chapel Hill13 trials
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill12 trials
  • Duke University, Durham9 trials
  • Duke University Medical Center, Durham9 trials
  • Levine Cancer Institute, Charlotte8 trials
By city

Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.

Breast Cancer clinical trials in North Carolina: common questions

How many Breast Cancer clinical trials are recruiting in North Carolina?
TrialFinder currently lists 156 recruiting Breast Cancer clinical trials with study sites in North Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Breast Cancer clinical trials located in North Carolina?
Study sites for the Breast Cancer trials listed on this page include Chapel Hill, Durham. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Breast Cancer clinical trial in North Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Breast Cancer trials in North Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Breast Cancer clinical trial in North Carolina?
Each study sets its own criteria based on age, Breast Cancer diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to know my receptor status to join a breast cancer trial?
It helps, because trials are organized by subtype, but the study site reads it from your pathology report. If a trial needs a test you have not had, such as HER2-low or a BRCA result, the site arranges it.
Are there trials for early-stage breast cancer?
Yes. Early-stage trials enroll before surgery, after surgery, or during the years of hormone therapy that follow, and test ways to lower the chance the cancer returns. The listing says which window it enrolls in.
Will a trial replace the treatment my oncologist planned?
Sometimes it is the plan, with a new drug added or compared; sometimes it is an alternative to discuss. Bring the trial page to your oncologist, who can refer you to the site or advise on timing.
Breast Cancer Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Breast Cancer Trials

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