24 Recruiting Trials
Clinical Trials
for Lupus in North Carolina
24 clinical trials for Lupus are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.
24
Recruiting trials
22
Study sites
7
Cities
18
Industry-sponsored
5
Phase 2
5
Phase 3
Lupus clinical trials in North Carolina: what to expect
Lupus trials are mostly for systemic lupus that stays active despite standard treatment. They test biologic infusions and injections that target the immune signals behind lupus, new oral medicines, and treatments that reduce the need for steroids. Lupus nephritis, where the disease affects the kidneys, has its own trials with their own entry rules, and cell-based therapies are beginning to be tested in people whose lupus has not responded to anything else.
In North Carolina, recruiting lupus studies are concentrated in Charlotte, Durham, Chapel Hill and Fayetteville, with sites in 3 other cities. 18 of the 24 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who lupus trials usually look for
Trials require a confirmed diagnosis with positive antibody tests, active disease above a threshold on a standard activity score at screening, and a stable regimen of your current medicines (an antimalarial, an immunosuppressant, a steroid below a stated dose) for several weeks beforehand. Lupus nephritis trials need a recent kidney biopsy and a protein-in-urine level above a cut-off. Common exclusions are severe active lupus of the brain, a recent biologic, serious infection and pregnancy. Ages are usually 18 to 75.
What taking part involves
Screening includes blood and urine tests and a review of your records. Most trials then last a year with visits every four weeks for an infusion or injection, lab monitoring and a disease-activity exam, often with a plan to taper steroids. The study drug is usually compared with placebo, both added to your existing treatment, and flares are treated as needed. An open-label extension generally follows. All study care is free and visits are usually paid.
Questions worth asking the study team
Whether your current medicines stay unchanged; how the steroid taper works; the chance of placebo and whether an extension follows; what happens during a flare; and what the trial means for pregnancy planning.
Showing 20 of 24 recruiting Lupus trials in North Carolina
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
Recruiting
This trial is looking for people aged 16 and older who have moderate to severe systemic lupus erythematosus (SLE) and are not getting enough improvement from their current medications. Participants will receive dapirolizumab pegol as an additional treatment along with their existing medications.
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)
Recruiting
This trial is looking for people with active skin symptoms of lupus, with or without other types of lupus disease. If you join, you will take a medication called enpatoran for 24 weeks and visit the study site every 4 weeks.
An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
Recruiting
This trial is looking for children with moderate to severe systemic lupus erythematosus (SLE) to test a treatment called Anifrolumab. Participants will be monitored to understand how well the treatment works and its safety.
A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
Recruiting
This trial is looking for adults with moderate to severe lupus. Participants will receive either the drug nipocalimab or a placebo to see how well it works.
A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)
Recruiting
This trial is looking for adults with systemic lupus erythematosus (SLE) to see if a medicine called BI 3000202 can help them. Participants will take the medicine or a placebo for one year while continuing their regular SLE treatment.
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
Recruiting
This trial is looking for adults with active systemic lupus erythematosus or lupus nephritis. Participants will receive the treatment CABA-201 and will be monitored for safety and effectiveness.
The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study
Recruiting
This trial is looking for young people aged 8 to 20 with lupus nephritis. Participants will take a medication called Mycophenolate Mofetil and visit the study site regularly for assessments.
A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis
Recruiting
This trial is looking for people with lupus nephritis who have not responded well to previous treatments. Participants will receive a new therapy, FT819, to see if it helps improve kidney function over 26 weeks.
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
Recruiting
This trial is looking for adults aged 18 to 70 who have severe systemic lupus erythematosus that hasn’t improved with other treatments. Participants will receive a special therapy called AZD0120 and will be monitored for its safety and effectiveness.
PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients With Lupus Nephritis
Recruiting
This trial is looking for adults with lupus nephritis who want to test a new combination treatment. Participants will need to take some specific medications and be within a certain age range.
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
Recruiting
This trial is looking for adults with Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, or Rheumatoid Arthritis. Participants will receive the study drug AZD5492 either once or twice during the trial period and will attend several check-up visits over at least 180 days.
Recruiting
Intervention to Improve Communication and Medication Adherence in Lupus
Recruiting
This trial is looking for adults with Lupus to help improve how patients and doctors communicate about medications. Participants will work with healthcare providers to better understand and overcome challenges with taking their medications.
A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants
Recruiting
This trial is looking for people with active systemic lupus erythematosus who have not responded well to previous treatments. Participants will need to meet specific health criteria and may undergo assessments to evaluate their condition.
Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN
Recruiting
This trial is looking for adults with lupus nephritis who have been treated with belimumab in the past 6 to 24 months. Participants will help understand how well this treatment works over time in real-life situations.
Lupus Landmark Study: A Prospective Registry and Biorepository
Recruiting
This trial is looking for adults aged 18 or older who have been diagnosed with systemic lupus erythematosus (SLE), including lupus nephritis. Participants will help gather important data and samples for future research.
Duke Lupus Registry
Recruiting
This trial is looking for patients with lupus who are seeing a rheumatologist at Duke University Medical Center. Participants will provide information and blood samples to help understand lupus over time.
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
Recruiting
This trial is looking for people who have finished another study with anifrolumab and are still benefiting from it. Participants will continue to receive anifrolumab and will be monitored for safety.
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
Recruiting
This trial is looking for adults with certain autoimmune diseases, like systemic lupus erythematosus and systemic sclerosis. Participants will receive the treatment CTX112 and will need to attend regular visits and follow study guidelines.
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
Recruiting
This trial is looking for adults between 18 and 75 years old who have active autoimmune diseases like lupus, myopathy, or scleroderma that haven't responded well to standard treatments. They also want to make sure participants are generally healthy and don’t have serious infections or certain other health issues, like recent heart problems or cancer. If someone has had certain types of previous treatments or has unstable health, they wouldn’t be able to join.
Where the Lupus studies are in North Carolina
Research sites running the most studies
- DJL Clinical Research, PLLC, Charlotte3 trials
- Duke University, Durham3 trials
- Cross Creek Medical Clinic, Fayetteville2 trials
- Duke University Medical Center, Durham2 trials
- Joint and Muscle Research Institute, Charlotte2 trials
- Research Site, Charlotte2 trials
By city
Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.
Lupus clinical trials in North Carolina: common questions
How many Lupus clinical trials are recruiting in North Carolina?
TrialFinder currently lists 24 recruiting Lupus clinical trials with study sites in North Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Lupus clinical trials located in North Carolina?
Study sites for the Lupus trials listed on this page include Durham, Charlotte. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Lupus clinical trial in North Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Lupus trials in North Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Lupus clinical trial in North Carolina?
Each study sets its own criteria based on age, Lupus diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will my regular lupus medicines stop if I join a trial?
No. Lupus trials add the study treatment to a stable regimen of your current medicines. Many include a planned steroid taper as one of the goals, managed by the study doctor.
Is there a placebo in lupus trials?
Usually, but always on top of standard treatment, never instead of it, and most trials move everyone onto the active drug in an extension after the main study period.
Can I join a trial if I have lupus nephritis?
Yes. Lupus nephritis has dedicated trials that require a recent kidney biopsy and a stated level of protein in the urine. General lupus trials often exclude active nephritis, so look for the ones that name it.
Lupus Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Lupus Trials
Lupus trials evaluate belimumab, anifrolumab, JAK inhibitors, and other biologics targeting the immune dysregulation behind systemic lupus erythematosus.
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