5 Recruiting Trials

Clinical Trials
for Lupus in Virginia

5 clinical trials for Lupus are currently recruiting participants at study sites in Virginia. Study-related care is provided at no cost.

5
Recruiting trials
5
Study sites
2
Cities
4
Industry-sponsored
2
Phase 2
2
Phase 3

Lupus clinical trials in Virginia: what to expect

Lupus trials are mostly for systemic lupus that stays active despite standard treatment. They test biologic infusions and injections that target the immune signals behind lupus, new oral medicines, and treatments that reduce the need for steroids. Lupus nephritis, where the disease affects the kidneys, has its own trials with their own entry rules, and cell-based therapies are beginning to be tested in people whose lupus has not responded to anything else.

In Virginia, recruiting lupus studies are concentrated in Richmond and Roanoke. 4 of the 5 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who lupus trials usually look for

Trials require a confirmed diagnosis with positive antibody tests, active disease above a threshold on a standard activity score at screening, and a stable regimen of your current medicines (an antimalarial, an immunosuppressant, a steroid below a stated dose) for several weeks beforehand. Lupus nephritis trials need a recent kidney biopsy and a protein-in-urine level above a cut-off. Common exclusions are severe active lupus of the brain, a recent biologic, serious infection and pregnancy. Ages are usually 18 to 75.

What taking part involves

Screening includes blood and urine tests and a review of your records. Most trials then last a year with visits every four weeks for an infusion or injection, lab monitoring and a disease-activity exam, often with a plan to taper steroids. The study drug is usually compared with placebo, both added to your existing treatment, and flares are treated as needed. An open-label extension generally follows. All study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines stay unchanged; how the steroid taper works; the chance of placebo and whether an extension follows; what happens during a flare; and what the trial means for pregnancy planning.

Showing 5 of 5 recruiting Lupus trials in Virginia

A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
PHASE3 Beverly Hills, California +4 sites NCT07438496
This trial is looking for adults with moderate to severe lupus. Participants will receive either the drug nipocalimab or a placebo to see how well it works.
Recruiting
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
PHASE2 Phoenix, Arizona +4 sites NCT05268289
This trial is looking for people with active lupus nephritis. Participants will take a medication called LNP023 along with their usual treatment to see how well it works and how safe it is.
Recruiting
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
PHASE1 San Francisco, California +4 sites NCT06897930
This trial is looking for adults aged 18 to 70 who have severe systemic lupus erythematosus that hasn’t improved with other treatments. Participants will receive a special therapy called AZD0120 and will be monitored for its safety and effectiveness.
Recruiting
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
PHASE3 Phoenix, Arizona +4 sites NCT07691970
This trial is looking for people who have finished another study with anifrolumab and are still benefiting from it. Participants will continue to receive anifrolumab and will be monitored for safety.
Recruiting
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
PHASE1 Birmingham, Alabama +4 sites NCT03816345
This trial is looking for adults with advanced cancers who also have autoimmune disorders. Participants will receive treatments that may include the drug nivolumab and possibly others to see how well they work together.
Recruiting

Where the Lupus studies are in Virginia

  • Carilion Clinic Virginia Tech Carilion School of Medicine, Roanoke1 trial
  • Research Site, Richmond1 trial
  • Research Site, Roanoke1 trial
  • VCU Massey Comprehensive Cancer Center, Richmond1 trial
  • Virginia Commonwealth University, Richmond1 trial

Counts are recruiting studies listing at least one site in Virginia, from ClinicalTrials.gov, refreshed every two days.

Lupus clinical trials in Virginia: common questions

How many Lupus clinical trials are recruiting in Virginia?
TrialFinder currently lists 5 recruiting Lupus clinical trials with study sites in Virginia. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Lupus clinical trials located in Virginia?
Sites for these Lupus trials are spread across Virginia. Open any trial to see its full list of participating locations and contact details.
Do I need insurance to join a Lupus clinical trial in Virginia?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Lupus trials in Virginia also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Lupus clinical trial in Virginia?
Each study sets its own criteria based on age, Lupus diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will my regular lupus medicines stop if I join a trial?
No. Lupus trials add the study treatment to a stable regimen of your current medicines. Many include a planned steroid taper as one of the goals, managed by the study doctor.
Is there a placebo in lupus trials?
Usually, but always on top of standard treatment, never instead of it, and most trials move everyone onto the active drug in an extension after the main study period.
Can I join a trial if I have lupus nephritis?
Yes. Lupus nephritis has dedicated trials that require a recent kidney biopsy and a stated level of protein in the urine. General lupus trials often exclude active nephritis, so look for the ones that name it.
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Lupus trials evaluate belimumab, anifrolumab, JAK inhibitors, and other biologics targeting the immune dysregulation behind systemic lupus erythematosus.

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