Lupus Trials / Trials in Tennessee
16 Recruiting Trials

Clinical Trials
for Lupus in Tennessee

16 clinical trials for Lupus are currently recruiting participants at study sites in Tennessee. Study-related care is provided at no cost.

16
Recruiting trials
13
Study sites
5
Cities
14
Industry-sponsored
3
Phase 2
4
Phase 3

Lupus clinical trials in Tennessee: what to expect

Lupus trials are mostly for systemic lupus that stays active despite standard treatment. They test biologic infusions and injections that target the immune signals behind lupus, new oral medicines, and treatments that reduce the need for steroids. Lupus nephritis, where the disease affects the kidneys, has its own trials with their own entry rules, and cell-based therapies are beginning to be tested in people whose lupus has not responded to anything else.

In Tennessee, recruiting lupus studies are concentrated in Jackson, Memphis, Murfreesboro and Nashville, with sites in 1 other city. 14 of the 16 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who lupus trials usually look for

Trials require a confirmed diagnosis with positive antibody tests, active disease above a threshold on a standard activity score at screening, and a stable regimen of your current medicines (an antimalarial, an immunosuppressant, a steroid below a stated dose) for several weeks beforehand. Lupus nephritis trials need a recent kidney biopsy and a protein-in-urine level above a cut-off. Common exclusions are severe active lupus of the brain, a recent biologic, serious infection and pregnancy. Ages are usually 18 to 75.

What taking part involves

Screening includes blood and urine tests and a review of your records. Most trials then last a year with visits every four weeks for an infusion or injection, lab monitoring and a disease-activity exam, often with a plan to taper steroids. The study drug is usually compared with placebo, both added to your existing treatment, and flares are treated as needed. An open-label extension generally follows. All study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines stay unchanged; how the steroid taper works; the chance of placebo and whether an extension follows; what happens during a flare; and what the trial means for pregnancy planning.

Showing 16 of 16 recruiting Lupus trials in Tennessee

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
PHASE3 Avondale, Arizona +4 sites NCT06617325
This trial is looking for people aged 16 and older who have moderate to severe systemic lupus erythematosus (SLE) and are not getting enough improvement from their current medications. Participants will receive dapirolizumab pegol as an additional treatment along with their existing medications.
Recruiting
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
PHASE3 Anniston, Alabama +4 sites NCT06133972
This trial is looking for people with systemic lupus erythematosus who have completed a previous study using ianalumab. Participants will be monitored for long-term safety and tolerance of the treatment.
Recruiting
A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus
PHASE3 Anniston, Alabama +4 sites NCT07430306
This trial is looking for adults with systemic lupus erythematosus (SLE) who have not used immunosuppressive drugs before. Participants will receive anifrolumab as an additional treatment to their regular medications for SLE.
Recruiting
A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
PHASE3 Beverly Hills, California +4 sites NCT07438496
This trial is looking for adults with moderate to severe lupus. Participants will receive either the drug nipocalimab or a placebo to see how well it works.
Recruiting
A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)
PHASE2 Beverly Hills, California +4 sites NCT07409181
This trial is looking for adults with systemic lupus erythematosus (SLE) to see if a medicine called BI 3000202 can help them. Participants will take the medicine or a placebo for one year while continuing their regular SLE treatment.
Recruiting
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study With an Open-Label Extension Evaluating the Efficacy and Safety of VENT-03 in Adult Participants With Active Cutaneous Lupus Erythematosus With or Without Systemic Lupus Erythematosus
PHASE2 Beverly Hills, California +4 sites NCT07260877
This trial is looking for adults with cutaneous lupus who may also have systemic lupus. Participants will take the study drug VENT-03 or a placebo for a total of 12 weeks and visit the clinic monthly for checkups.
Recruiting
2-HOBA in Systemic Lupus Erythematosus
PHASE2 Nashville, Tennessee NCT07225543
This trial is looking for women with stable systemic lupus erythematosus (SLE) to test a treatment called 2-HOBA. Participants will take either 2-HOBA or a placebo for 8 weeks, then switch to the other treatment after a break.
Recruiting
A Study to Continue the Administration of Deucravacitinib in Participants With Systemic Lupus Erythematosus (SLE) or Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE) Who Have Completed Study IM011074 or Study IM011132
PHASE4 Jackson, Tennessee +3 sites NCT06875960
This trial is looking for people who have lupus and want to continue their treatment with Deucravacitinib. To join, you need to have finished certain previous studies and be assessed by a doctor to see if you can benefit from further treatment.
Recruiting
PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients With Lupus Nephritis
PHASE4 La Mesa, California +4 sites NCT07611214
This trial is looking for adults with lupus nephritis who want to test a new combination treatment. Participants will need to take some specific medications and be within a certain age range.
Recruiting
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)
PHASE1 Anniston, Alabama +4 sites NCT07607964
This trial is looking for adults with systemic lupus erythematosus or rheumatoid arthritis. Participants will receive treatment and attend regular check-ups to assess the effects and safety of the drug.
Recruiting
A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants
N/A La Jolla, California +4 sites NCT07175285
This trial is looking for people with active systemic lupus erythematosus who have not responded well to previous treatments. Participants will need to meet specific health criteria and may undergo assessments to evaluate their condition.
Recruiting
Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN
N/A Hixson, Tennessee +4 sites NCT06527872
This trial is looking for adults with lupus nephritis who have been treated with belimumab in the past 6 to 24 months. Participants will help understand how well this treatment works over time in real-life situations.
Recruiting
Lupus Landmark Study: A Prospective Registry and Biorepository
N/A Birmingham, Alabama +4 sites NCT05934149
This trial is looking for adults aged 18 or older who have been diagnosed with systemic lupus erythematosus (SLE), including lupus nephritis. Participants will help gather important data and samples for future research.
Recruiting
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and Rheumatoid Arthritis (RA)
PHASE1 Avon Park, Florida +4 sites NCT06977724
This trial is looking for adults with systemic lupus erythematosus, Sjogren's disease, or rheumatoid arthritis. Participants will receive two doses of an investigational drug called ABBV-319 and will be monitored for about a year.
Recruiting
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
PHASE1 Avondale, Arizona +4 sites NCT06613360
This trial is looking for patients with Moderate to Severe Systemic Lupus Erythematosus (SLE) who have not responded well to previous treatments. Participants will receive a medication called CLN-978 through a subcutaneous injection.
Recruiting
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
PHASE1 Beverly Hills, California +4 sites NCT06308978
This trial is looking for people between the ages of 12 and 70 who have certain autoimmune diseases that are not responding to previous treatments. They should generally be in good health, but not have serious heart or lung problems, active infections, or recent cancer. Also, women can't be pregnant or breastfeeding, and participants need to weigh at least 50 kg.
Recruiting
See all 16 Lupus trials in Tennessee

Where the Lupus studies are in Tennessee

Research sites running the most studies
  • West Tennessee Research Institute, Jackson4 trials
  • Regional One Health, Memphis2 trials
  • Shelby Research LLC, Memphis2 trials
  • Vanderbilt University Medical Center, Nashville2 trials
  • GSK Investigational Site, Hixson1 trial
  • Investigative Site, Memphis1 trial
By city

Counts are recruiting studies listing at least one site in Tennessee, from ClinicalTrials.gov, refreshed every two days.

Lupus clinical trials in Tennessee: common questions

How many Lupus clinical trials are recruiting in Tennessee?
TrialFinder currently lists 16 recruiting Lupus clinical trials with study sites in Tennessee. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Lupus clinical trials located in Tennessee?
Study sites for the Lupus trials listed on this page include Nashville, Jackson, Hixson. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Lupus clinical trial in Tennessee?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Lupus trials in Tennessee also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Lupus clinical trial in Tennessee?
Each study sets its own criteria based on age, Lupus diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will my regular lupus medicines stop if I join a trial?
No. Lupus trials add the study treatment to a stable regimen of your current medicines. Many include a planned steroid taper as one of the goals, managed by the study doctor.
Is there a placebo in lupus trials?
Usually, but always on top of standard treatment, never instead of it, and most trials move everyone onto the active drug in an extension after the main study period.
Can I join a trial if I have lupus nephritis?
Yes. Lupus nephritis has dedicated trials that require a recent kidney biopsy and a stated level of protein in the urine. General lupus trials often exclude active nephritis, so look for the ones that name it.
Lupus Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Lupus Trials

Lupus trials evaluate belimumab, anifrolumab, JAK inhibitors, and other biologics targeting the immune dysregulation behind systemic lupus erythematosus.

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