Lupus Trials / Trials in Indiana
5 Recruiting Trials

Clinical Trials
for Lupus in Indiana

5 clinical trials for Lupus are currently recruiting participants at study sites in Indiana. Study-related care is provided at no cost.

5
Recruiting trials
5
Study sites
2
Cities
5
Industry-sponsored
2
Phase 2
3
Phase 3

Lupus clinical trials in Indiana: what to expect

Lupus trials are mostly for systemic lupus that stays active despite standard treatment. They test biologic infusions and injections that target the immune signals behind lupus, new oral medicines, and treatments that reduce the need for steroids. Lupus nephritis, where the disease affects the kidneys, has its own trials with their own entry rules, and cell-based therapies are beginning to be tested in people whose lupus has not responded to anything else.

In Indiana, recruiting lupus studies are concentrated in Indianapolis and New Albany. 5 of the 5 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who lupus trials usually look for

Trials require a confirmed diagnosis with positive antibody tests, active disease above a threshold on a standard activity score at screening, and a stable regimen of your current medicines (an antimalarial, an immunosuppressant, a steroid below a stated dose) for several weeks beforehand. Lupus nephritis trials need a recent kidney biopsy and a protein-in-urine level above a cut-off. Common exclusions are severe active lupus of the brain, a recent biologic, serious infection and pregnancy. Ages are usually 18 to 75.

What taking part involves

Screening includes blood and urine tests and a review of your records. Most trials then last a year with visits every four weeks for an infusion or injection, lab monitoring and a disease-activity exam, often with a plan to taper steroids. The study drug is usually compared with placebo, both added to your existing treatment, and flares are treated as needed. An open-label extension generally follows. All study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines stay unchanged; how the steroid taper works; the chance of placebo and whether an extension follows; what happens during a flare; and what the trial means for pregnancy planning.

Showing 5 of 5 recruiting Lupus trials in Indiana

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
PHASE3 Avondale, Arizona +4 sites NCT06617325
This trial is looking for people aged 16 and older who have moderate to severe systemic lupus erythematosus (SLE) and are not getting enough improvement from their current medications. Participants will receive dapirolizumab pegol as an additional treatment along with their existing medications.
Recruiting
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)
PHASE3 Upland, California +4 sites NCT07355218
This trial is looking for people with active skin symptoms of lupus, with or without other types of lupus disease. If you join, you will take a medication called enpatoran for 24 weeks and visit the study site every 4 weeks.
Recruiting
A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus
PHASE3 Anniston, Alabama +4 sites NCT07430306
This trial is looking for adults with systemic lupus erythematosus (SLE) who have not used immunosuppressive drugs before. Participants will receive anifrolumab as an additional treatment to their regular medications for SLE.
Recruiting
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
PHASE2 Indianapolis, Indiana +4 sites NCT05039619
This trial is looking for teenagers aged 12 to 18 and children aged 5 to under 12 who have been diagnosed with lupus nephritis. Participants will receive treatment with obinutuzumab and be monitored for safety and effectiveness.
Recruiting
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study With an Open-Label Extension Evaluating the Efficacy and Safety of VENT-03 in Adult Participants With Active Cutaneous Lupus Erythematosus With or Without Systemic Lupus Erythematosus
PHASE2 Beverly Hills, California +4 sites NCT07260877
This trial is looking for adults with cutaneous lupus who may also have systemic lupus. Participants will take the study drug VENT-03 or a placebo for a total of 12 weeks and visit the clinic monthly for checkups.
Recruiting
See all 5 Lupus trials in Indiana

Where the Lupus studies are in Indiana

Research sites running the most studies
  • Dawes Fretzin Clinical Research Group, LLC, Indianapolis1 trial
  • Indiana University Health University Hospital, Indianapolis1 trial
  • Investigative Site, Indianapolis1 trial
  • Research Site, New Albany1 trial
  • Sl0044 50748, New Albany1 trial
By city

Counts are recruiting studies listing at least one site in Indiana, from ClinicalTrials.gov, refreshed every two days.

Lupus clinical trials in Indiana: common questions

How many Lupus clinical trials are recruiting in Indiana?
TrialFinder currently lists 5 recruiting Lupus clinical trials with study sites in Indiana. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Lupus clinical trials located in Indiana?
Study sites for the Lupus trials listed on this page include Indianapolis. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Lupus clinical trial in Indiana?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Lupus trials in Indiana also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Lupus clinical trial in Indiana?
Each study sets its own criteria based on age, Lupus diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will my regular lupus medicines stop if I join a trial?
No. Lupus trials add the study treatment to a stable regimen of your current medicines. Many include a planned steroid taper as one of the goals, managed by the study doctor.
Is there a placebo in lupus trials?
Usually, but always on top of standard treatment, never instead of it, and most trials move everyone onto the active drug in an extension after the main study period.
Can I join a trial if I have lupus nephritis?
Yes. Lupus nephritis has dedicated trials that require a recent kidney biopsy and a stated level of protein in the urine. General lupus trials often exclude active nephritis, so look for the ones that name it.
Lupus Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Lupus Trials

Lupus trials evaluate belimumab, anifrolumab, JAK inhibitors, and other biologics targeting the immune dysregulation behind systemic lupus erythematosus.

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Other Conditions in Indiana
Diabetes Cancer Breast Cancer Depression Anxiety Alzheimer's Heart Disease Asthma Multiple Sclerosis Obesity Parkinson's Hypertension COPD Stroke Arthritis Kidney Disease COVID-19
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