Depression Trials / Trials in Indiana
12 Recruiting Trials

Clinical Trials
for Depression in Indiana

12 clinical trials for Depression are currently recruiting participants at study sites in Indiana. Study-related care is provided at no cost.

12
Recruiting trials
16
Study sites
7
Cities
6
Industry-sponsored
2
Phase 2
3
Phase 3

Depression clinical trials in Indiana: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Indiana, recruiting depression studies are concentrated in Indianapolis, South Bend, Bloomington and Carmel, with sites in 3 other cities. 6 of the 12 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 12 of 12 recruiting Depression trials in Indiana

Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
NA Indianapolis, Indiana +1 sites NCT06627894
This trial is looking for older adults who were in intensive care and are experiencing depression and cognitive decline. Participants will use an online program to help manage their depression.
Recruiting
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
PHASE3 Dothan, Alabama +4 sites NCT06372964
This trial is looking for young people aged 10 to 17 who have bipolar depression. Participants will receive either the study medication or a placebo while their mood is monitored.
Recruiting
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
PHASE2 Birmingham, Alabama +4 sites NCT07553637
This trial is looking for adults aged 18 to 75 who have moderate to severe depression that hasn't improved with other treatments. Participants will compare the effects of ALTO-207 with a placebo.
Recruiting
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NA Birmingham, Alabama +4 sites NCT06423430
This trial is looking for adults with treatment resistant depression who have not improved with other treatments. Participants will receive a new type of brain stimulation as part of their care.
Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NA Birmingham, Alabama +4 sites NCT03887715
This trial is looking for adults with treatment-resistant depression. Participants will receive either active VNS therapy or a control without stimulation to see how it affects their depression over 12 months.
Recruiting
rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression
NA Indianapolis, Indiana NCT06511544
This trial is looking for adults with major depression that has not improved with medication. Participants will receive TMS treatment and undergo brain scans while completing related tasks.
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
PHASE3 Bentonville, Arkansas +4 sites NCT04777357
This trial is looking for young people aged 10 to 17 who have bipolar I disorder and are experiencing depressive episodes. Participants will receive either a study drug called cariprazine or a placebo to see how it affects their mood.
Recruiting
Equipping Patients Using Interventions for Pain and Depression
NA Indianapolis, Indiana NCT06500780
This trial is looking for Black patients with chronic pain and depression. Participants will receive coaching to help them use non-drug treatments for pain over about 12 weeks.
Recruiting
ALTO-100 in Bipolar Disorder With Depression (BD-D)
PHASE2 Birmingham, Alabama +4 sites NCT06656416
This trial is looking for adults who have bipolar disorder along with a current major depressive episode and are already taking a mood stabilizer. It’s important that they haven't changed their medication in the last two weeks and are not pregnant or breastfeeding. They can't have other serious health issues, be currently using certain medications, or have a history of severe substance use problems.
Recruiting
TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
N/A Bloomington, Indiana +4 sites NCT07048574
This trial is looking for children aged 18 months to 11 years who have cystic fibrosis. Participation involves being followed by a care team and discussing mental health issues like depression and anxiety.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV
NA Indianapolis, Indiana NCT07226128
This trial is looking for adults with HIV who are experiencing depression. Participants will receive 9 weeks of online therapy to see if it can improve how their body uses insulin.
Recruiting
See all 12 Depression trials in Indiana

Where the Depression studies are in Indiana

Research sites running the most studies
  • Indiana University, Indianapolis2 trials
  • Advanced Research Institute, Inc., Indianapolis1 trial
  • Baptist Health Floyd, New Albany1 trial
  • Beacon Medical Group Behavioral Health, South Bend1 trial
  • Eskenazi Health Primary Care, Indianapolis1 trial
  • Eskenazi Hospital, Indianapolis1 trial
By city

Counts are recruiting studies listing at least one site in Indiana, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Indiana: common questions

How many Depression clinical trials are recruiting in Indiana?
TrialFinder currently lists 12 recruiting Depression clinical trials with study sites in Indiana. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Indiana?
Study sites for the Depression trials listed on this page include Indianapolis, Bloomington. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in Indiana?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Indiana also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Indiana?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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