Internet CBT for Depression and Cognitive Decline

Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Recruiting N/A Interventional Study
Depression Cognitive Decline
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
50 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
300 (estimated)
Sponsor
Indiana University · Other
Who this trial is looking for

This trial is looking for older adults who were in intensive care and are experiencing depression and cognitive decline. Participants will use an online program to help manage their depression.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am 50 years old or older
  • I was in intensive care for more than 48 hours
  • I can understand and give consent
  • I have elevated depressive symptoms
  • I am willing to participate in cognitive testing
  • I have access to a telephone
  • I have been discharged to home or an independent or assisted living facility
  • I have noticed changes in my memory or thinking

You may not be able to join if

  • I have been diagnosed with dementia or a neurodegenerative disease
  • I have a diagnosis of severe mental illness
  • I have persistent psychotic symptoms after my ICU stay
  • I have a recent or recurrent alcohol or substance use disorder
  • My life expectancy is less than 1 year
  • I have had a stroke or traumatic brain injury recently
  • I have uncorrected vision or hearing impairment
  • I am currently incarcerated or on parole

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an …
Trial Locations
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Eligibility Criteria
Inclusion Criteria 1. 50 years of age and older 2. Admitted to the intensive care for greater \> 48 hours 3. Able to understand and provide informed consent 4. Elevated depressive symptoms, defined as Screening PHQ-9 or PHQ-8 ≥ 10 or Screening PHQ-9 or PHQ-8 = 5-9 with the presence a core symptom o…
Contacts

Babar Khan, MD, MS

317-274-9132

bakhan@iu.edu

CONTACT

Lori Rawlings, RN, BSN

317-274-9052

rawlingl@regenstrief.org

CONTACT