Depression Trials / Trials in Oregon
8 Recruiting Trials

Clinical Trials
for Depression in Oregon

8 clinical trials for Depression are currently recruiting participants at study sites in Oregon. Study-related care is provided at no cost.

8
Recruiting trials
16
Study sites
9
Cities
2
Industry-sponsored
3
Phase 3

Depression clinical trials in Oregon: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Oregon, recruiting depression studies are concentrated in Portland, Bend, Eugene and Hood River, with sites in 5 other cities. 2 of the 8 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 8 of 8 recruiting Depression trials in Oregon

ICBT (Internet Based Cognitive Behavioral Therapy) for Maternal Depression: Community Implementation in Head Start
NA Springfield, Oregon NCT05142384
This trial is looking for mothers with signs of depression who have children aged 2-5 enrolled in Head Start programs. By participating, mothers can receive an online therapy program designed to help reduce their depression and improve parenting skills.
Recruiting
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
PHASE3 Portland, Oregon +4 sites NCT07226232
This trial is looking for U.S. military veterans experiencing major depression. Participants will take psilocybin and be monitored to see how it affects their condition.
Recruiting
Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function
NA Eugene, Oregon NCT05691439
This trial is looking for adolescents aged 14-18 who are currently in high school. Participants will help researchers learn about the relationship between sleep, stress, and depression.
Recruiting
Observational Study of THC Concentrations in Acute Cannabis-induced CNS Depression
N/A Portland, Oregon +2 sites NCT06017622
This trial is looking for children under 18 who show symptoms of cannabis-related brain depression after using cannabis. Participants will have blood samples taken during their visit to the emergency department to check THC levels.
Recruiting
Implementation of Problem-Solving Treatment in Community Health Centers (PST-Aid)
NA Portland, Oregon NCT06494384
This trial is looking for community health practitioners and adults with depression. Participants will use a web-based app to help set goals and plan actions for treatment.
Recruiting
Reaching Out to Distressed Medical Residents, Fellows and Faculty
NA Portland, Oregon NCT02010866
This trial is looking for medical residents, fellows, and faculty who are feeling stressed or distressed. Participants will take an anonymous online screening about their mental health and can interact with a clinician online.
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
PHASE3 Tucson, Arizona +4 sites NCT07484217
This trial is looking for adults with major depressive disorder and excessive daytime sleepiness symptoms. Participants will first take solriamfetol openly, followed by a period where neither the participant nor the doctor knows if the treatment is the drug or a placebo.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
See all 8 Depression trials in Oregon

Where the Depression studies are in Oregon

Research sites running the most studies
  • Clinical Research Site, Portland1 trial
  • Kaiser Permanente Northwest, Portland1 trial
  • OCHIN, Inc., Portland1 trial
  • Oregon Health and Science University, Portland1 trial
  • Oregon Health and Sciences University, Portland1 trial
  • Oregon Research Institute, Springfield1 trial
By city

Counts are recruiting studies listing at least one site in Oregon, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Oregon: common questions

How many Depression clinical trials are recruiting in Oregon?
TrialFinder currently lists 8 recruiting Depression clinical trials with study sites in Oregon. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Oregon?
Study sites for the Depression trials listed on this page include Springfield, Portland, Eugene. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in Oregon?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Oregon also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Oregon?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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Other Conditions in Oregon
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