Depression Trials / Trials in Rhode Island
7 Recruiting Trials

Clinical Trials
for Depression in Rhode Island

7 clinical trials for Depression are currently recruiting participants at study sites in Rhode Island. Study-related care is provided at no cost.

7
Recruiting trials
6
Study sites
2
Cities
1
Industry-sponsored
1
Phase 2
1
Phase 3

Depression clinical trials in Rhode Island: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Rhode Island, recruiting depression studies are concentrated in Providence and East Providence. 1 of the 7 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 7 of 7 recruiting Depression trials in Rhode Island

Brain Connectivity in Depression
NA Providence, Rhode Island +3 sites NCT03276793
This trial is looking for adults with depression who have not responded to other treatments. Participants will receive transcranial magnetic stimulation (TMS) therapy and take part in various assessments involving brain scans and tests.
Recruiting
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
PHASE2 Birmingham, Alabama +4 sites NCT07553637
This trial is looking for adults aged 18 to 75 who have moderate to severe depression that hasn't improved with other treatments. Participants will compare the effects of ALTO-207 with a placebo.
Recruiting
Feasibility and Acceptability of a Novel Digital Intervention to Prevent Paternal Postpartum Depression
NA Providence, Rhode Island NCT07594743
This trial is looking for new or expectant fathers who want to use a digital program to help prevent postpartum depression. Participants will access educational materials like podcasts to support their mental health during this time.
Recruiting
Collaborative Care Model for Perinatal Wellness Support Services - Population-Level Equity-Centered Systems Change
NA Providence, Rhode Island NCT06849869
This trial is looking for pregnant and postpartum people who are at least 20 weeks along in their pregnancy. Participants will help evaluate a new support program aimed at improving mental health during this period.
Recruiting
TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
N/A Orange, California +4 sites NCT07048574
This trial is looking for children aged 18 months to 11 years who have cystic fibrosis. Participation involves being followed by a care team and discussing mental health issues like depression and anxiety.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers
NA Providence, Rhode Island NCT06737055
This trial is looking for expectant mothers or new parents who have difficulty sleeping. Participants will learn about a sleep program designed to help manage their sleep issues during and after pregnancy.
Recruiting
See all 7 Depression trials in Rhode Island

Where the Depression studies are in Rhode Island

Research sites running the most studies
  • Women and Infants Hospital, Providence2 trials
  • Brown University Health, Providence1 trial
  • Butler Hospital, Providence1 trial
  • Rhode Island Hospital, Providence1 trial
  • Site 7172, East Providence1 trial
  • Women & Infants Hospital of Rhode Island, Providence1 trial
By city

Counts are recruiting studies listing at least one site in Rhode Island, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Rhode Island: common questions

How many Depression clinical trials are recruiting in Rhode Island?
TrialFinder currently lists 7 recruiting Depression clinical trials with study sites in Rhode Island. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Rhode Island?
Study sites for the Depression trials listed on this page include Providence. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in Rhode Island?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Rhode Island also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Rhode Island?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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Other Conditions in Rhode Island
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