Depression Trials / Trials in Oklahoma
14 Recruiting Trials

Clinical Trials
for Depression in Oklahoma

14 clinical trials for Depression are currently recruiting participants at study sites in Oklahoma. Study-related care is provided at no cost.

14
Recruiting trials
18
Study sites
4
Cities
6
Industry-sponsored
3
Phase 2
6
Phase 3

Depression clinical trials in Oklahoma: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Oklahoma, recruiting depression studies are concentrated in Oklahoma City, Tulsa, Moore and Edmond. 6 of the 14 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 14 of 14 recruiting Depression trials in Oklahoma

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
PHASE3 Moore, Oklahoma +4 sites NCT06713616
This trial is looking for adults with depression that hasn't improved with other treatments. Participants will receive either a nasal spray or an IV treatment and help researchers learn how well these options work and how they feel about them.
Recruiting
Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression
PHASE2 Tulsa, Oklahoma NCT06263660
This trial is looking for adults with moderate to severe depression to see if a keto-like supplement changes brain responses. Participation involves taking the supplement or a placebo for 8 weeks and attending several visits for assessments and imaging.
Recruiting
Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
PHASE4 Tulsa, Oklahoma NCT06004115
This trial is looking for adults aged 18-65 who have depression and possibly anxiety. Participants will take a dose of Lorazepam and be involved in brain imaging and startle response tests over a couple of sessions.
Recruiting
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
PHASE3 Dothan, Alabama +4 sites NCT06372964
This trial is looking for young people aged 10 to 17 who have bipolar depression. Participants will receive either the study medication or a placebo while their mood is monitored.
Recruiting
Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression
PHASE1 Tulsa, Oklahoma NCT06088732
This trial is looking for adults with bipolar depression to test how exercise and ibuprofen affect their symptoms and health. Participants will exercise or rest in different sessions and take either ibuprofen or a placebo.
Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NA Birmingham, Alabama +4 sites NCT03887715
This trial is looking for adults with treatment-resistant depression. Participants will receive either active VNS therapy or a control without stimulation to see how it affects their depression over 12 months.
Recruiting
Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression
NA Tulsa, Oklahoma NCT07166289
This trial is looking for adults aged 18-65 who have severe depression that has not improved with regular treatments. Participants will receive a non-invasive ultrasound treatment aimed at helping the brain function better.
Recruiting
The OBSERVE Protocol
N/A Moore, Oklahoma +4 sites NCT06725277
This trial is looking for adults with major depression who are starting or continuing treatment with Spravato or IV ketamine. Participants will help us learn about the effectiveness and safety of these treatments over a 5-year period.
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
PHASE3 Bentonville, Arkansas +4 sites NCT04777357
This trial is looking for young people aged 10 to 17 who have bipolar I disorder and are experiencing depressive episodes. Participants will receive either a study drug called cariprazine or a placebo to see how it affects their mood.
Recruiting
Amplification of Positivity for Alcohol Use
NA Tulsa, Oklahoma NCT06030154
This trial is looking for adults aged 18 to 65 who have depression or anxiety disorders along with alcohol use disorder. Participants will take part in a program aimed at enhancing positive feelings while providing feedback on the treatment.
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
PHASE3 Tucson, Arizona +4 sites NCT07484217
This trial is looking for adults with major depressive disorder and excessive daytime sleepiness symptoms. Participants will first take solriamfetol openly, followed by a period where neither the participant nor the doctor knows if the treatment is the drug or a placebo.
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
PHASE2 Huntsville, Alabama +4 sites NCT06696755
This trial is looking for adults with bipolar I or II disorder to test the drug Icalcaprant. Participants will take capsules daily for 6 weeks and have follow-up visits to monitor their health and side effects.
Recruiting
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
PHASE3 Birmingham, Alabama +4 sites NCT06793397
This trial is looking for adults with major depressive disorder to see if CYB003 is effective and safe. Participants will take either the drug or a placebo while continuing their current antidepressant medication.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
See all 14 Depression trials in Oklahoma

Where the Depression studies are in Oklahoma

Research sites running the most studies
  • Laureate Institute for Brain Research, Tulsa5 trials
  • LifeStance Health, Moore2 trials
  • Clinical Research Site, Edmond1 trial
  • Clinical Research Site, Oklahoma City1 trial
  • Cutting Edge Research Group, Oklahoma City1 trial
  • Cutting Edge Research Group /ID# 240777, Oklahoma City1 trial
By city

Counts are recruiting studies listing at least one site in Oklahoma, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Oklahoma: common questions

How many Depression clinical trials are recruiting in Oklahoma?
TrialFinder currently lists 14 recruiting Depression clinical trials with study sites in Oklahoma. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Oklahoma?
Study sites for the Depression trials listed on this page include Moore, Tulsa. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in Oklahoma?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Oklahoma also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Oklahoma?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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Other Conditions in Oklahoma
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