Depression Trials / Trials in New Jersey
18 Recruiting Trials

Clinical Trials
for Depression in New Jersey

18 clinical trials for Depression are currently recruiting participants at study sites in New Jersey. Study-related care is provided at no cost.

18
Recruiting trials
36
Study sites
26
Cities
11
Industry-sponsored
3
Phase 2
6
Phase 3

Depression clinical trials in New Jersey: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In New Jersey, recruiting depression studies are concentrated in Toms River, Basking Ridge, Middletown and Montvale, with sites in 22 other cities. 11 of the 18 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 18 of 18 recruiting Depression trials in New Jersey

Brexanolone Lifting Outcomes Of Moms
PHASE3 Tucson, Arizona +4 sites NCT07822321
This trial is looking for women aged 15 to 45 who are experiencing severe postpartum depression. Participants will take the study drug LPCN 1154A to see if it helps reduce their depressive symptoms and to learn about any side effects.
Recruiting
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
PHASE2 Tucson, Arizona +4 sites NCT06524830
This trial is looking for adults with treatment resistant depression. Participants will receive either a new treatment called VLS-01 Buccal Film or a placebo to see how effective it is.
Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NA Birmingham, Alabama +4 sites NCT03887715
This trial is looking for adults with treatment-resistant depression. Participants will receive either active VNS therapy or a control without stimulation to see how it affects their depression over 12 months.
Recruiting
Transcranial Direct Current Stimulation for Depression
NA Woodbridge, New Jersey NCT07042217
This trial is looking for adults with unipolar depression to test a treatment called transcranial direct current stimulation (tDCS) combined with mindfulness. Participants will receive this treatment through telemedicine.
Recruiting
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NA Birmingham, Alabama +4 sites NCT06423430
This trial is looking for adults with treatment resistant depression who have not improved with other treatments. Participants will receive a new type of brain stimulation as part of their care.
Recruiting
OBWELL: Innovative Psychotherapeutic Intervention to Treat Postpartum Depression
NA Hackensack, New Jersey NCT06991166
This trial is looking for mothers of infants in the NICU who are experiencing postpartum depression. Participants will be involved in therapy sessions using either cognitive behavioral therapy or interpersonal therapy to help with their symptoms.
Recruiting
Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention
NA Gibbsboro, New Jersey +4 sites NCT05748730
This trial is looking for teenagers aged 12 to 18 who are experiencing depression or suicidal thoughts. Participants will either receive the iCHART intervention or standard treatment while being closely monitored.
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
PHASE3 Bentonville, Arkansas +4 sites NCT04777357
This trial is looking for young people aged 10 to 17 who have bipolar I disorder and are experiencing depressive episodes. Participants will receive either a study drug called cariprazine or a placebo to see how it affects their mood.
Recruiting
SilverCloud as a School-Based Intervention for Vulnerable Youth
NA New Brunswick, New Jersey +2 sites NCT06004414
This trial is looking for high school students experiencing depression or anxiety. Participants will use the SilverCloud app for mental health support and share their experiences to improve the program.
Recruiting
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
PHASE3 Tucson, Arizona +4 sites NCT07172516
This trial is looking for adults aged 18 to 74 who are currently experiencing a depressive episode connected to bipolar disorder. Participants will receive either azetukalner or a placebo to see how well it works and its safety.
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
PHASE3 Tucson, Arizona +4 sites NCT07484217
This trial is looking for adults with major depressive disorder and excessive daytime sleepiness symptoms. Participants will first take solriamfetol openly, followed by a period where neither the participant nor the doctor knows if the treatment is the drug or a placebo.
Recruiting
ALTO-100 in Bipolar Disorder With Depression (BD-D)
PHASE2 Birmingham, Alabama +4 sites NCT06656416
This trial is looking for adults who have bipolar disorder along with a current major depressive episode and are already taking a mood stabilizer. It’s important that they haven't changed their medication in the last two weeks and are not pregnant or breastfeeding. They can't have other serious health issues, be currently using certain medications, or have a history of severe substance use problems.
Recruiting
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
PHASE2 Bentonville, Arkansas +4 sites NCT07300969
This trial is looking for adults with recurrent depression to see if DT-101 can help. Participants will visit the clinic every couple of weeks for health checks and to complete questionnaires.
Recruiting
A Study of a One-Time Counseling Session to Help Reduce Depression, Anxiety, and Distress in People With Cancer
NA Basking Ridge, New Jersey +4 sites NCT07218250
This trial is looking for women with breast cancer who are waiting for counseling services. Participants will attend a one-time 60-minute counseling session to help reduce feelings of anxiety and depression.
Recruiting
DESCANSO, a Mental Health Intervention for Depression, Insomnia, and Fatigue Symptoms in Latino People With Cancer
NA Basking Ridge, New Jersey +4 sites NCT07225088
This trial is looking for Latino people with solid tumor cancer who are dealing with depression, trouble sleeping, and fatigue. Participants will try a special mental health support called DESCANSO, which can be done through telehealth.
Recruiting
Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma
NA Basking Ridge, New Jersey +4 sites NCT06129903
This trial is looking for adults with soft tissue or bone sarcoma who are scheduled for surgery. Participants will receive early access to mental healthcare to see how it affects their mood, recovery, and overall satisfaction.
Recruiting
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
PHASE3 Birmingham, Alabama +4 sites NCT06793397
This trial is looking for adults with major depressive disorder to see if CYB003 is effective and safe. Participants will take either the drug or a placebo while continuing their current antidepressant medication.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
See all 18 Depression trials in New Jersey

Where the Depression studies are in New Jersey

Research sites running the most studies
  • Bio Behavioral Health, Toms River3 trials
  • Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale2 trials
  • AtlantiCare Health Park-Cape May Court House, Cape May Court House1 trial
  • AtlantiCare Surgery Center, Egg Harbor1 trial
  • Bayshore Community Hospital, Holmdel1 trial
  • Clinical Research Site, Cherry Hill1 trial
By city

Counts are recruiting studies listing at least one site in New Jersey, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in New Jersey: common questions

How many Depression clinical trials are recruiting in New Jersey?
TrialFinder currently lists 18 recruiting Depression clinical trials with study sites in New Jersey. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in New Jersey?
Study sites for the Depression trials listed on this page include Woodbridge, Hackensack, Gibbsboro, New Brunswick, Basking Ridge. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in New Jersey?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in New Jersey also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in New Jersey?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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