3 Recruiting Trials

Clinical Trials
for Depression in West Virginia

3 clinical trials for Depression are currently recruiting participants at study sites in West Virginia. Study-related care is provided at no cost.

3
Recruiting trials
4
Study sites
4
Cities
2
Industry-sponsored
1
Phase 2

Depression clinical trials in West Virginia: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In West Virginia, recruiting depression studies are concentrated in Huntington, Lewisburg, Morgantown and South Charleston. 2 of the 3 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 3 of 3 recruiting Depression trials in West Virginia

ALTO-207 in Adults With Treatment-resistant Depression (TRD)
PHASE2 Birmingham, Alabama +4 sites NCT07553637
This trial is looking for adults aged 18 to 75 who have moderate to severe depression that hasn't improved with other treatments. Participants will compare the effects of ALTO-207 with a placebo.
Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NA Birmingham, Alabama +4 sites NCT03887715
This trial is looking for adults with treatment-resistant depression. Participants will receive either active VNS therapy or a control without stimulation to see how it affects their depression over 12 months.
Recruiting
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
NA Lewisburg, West Virginia NCT06049420
This trial is looking for patients living in rural West Virginia with multiple chronic diseases. Participants will be involved in a program focused on improving lifestyle through physical activity and healthy habits.
Recruiting

Where the Depression studies are in West Virginia

  • Marshall University Joan C. Edwards School of Medicine, Huntington1 trial
  • Site 7163, South Charleston1 trial
  • West Virginia Clinical and Translational Science Institute, Morgantown1 trial
  • West Virginia School of Osteopathic Medicine, Lewisburg1 trial

Counts are recruiting studies listing at least one site in West Virginia, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in West Virginia: common questions

How many Depression clinical trials are recruiting in West Virginia?
TrialFinder currently lists 3 recruiting Depression clinical trials with study sites in West Virginia. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in West Virginia?
Study sites for the Depression trials listed on this page include Lewisburg. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in West Virginia?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in West Virginia also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in West Virginia?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
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Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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