Depression Trials / Trials in Georgia
28 Recruiting Trials

Clinical Trials
for Depression in Georgia

28 clinical trials for Depression are currently recruiting participants at study sites in Georgia. Study-related care is provided at no cost.

28
Recruiting trials
50
Study sites
15
Cities
16
Industry-sponsored
11
Phase 2
9
Phase 3

Depression clinical trials in Georgia: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Georgia, recruiting depression studies are concentrated in Atlanta, Decatur, Marietta and Savannah, with sites in 11 other cities. 16 of the 28 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 20 of 28 recruiting Depression trials in Georgia

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
PHASE3 Atlanta, Georgia +4 sites NCT06713616
This trial is looking for adults with depression that hasn't improved with other treatments. Participants will receive either a nasal spray or an IV treatment and help researchers learn how well these options work and how they feel about them.
Recruiting
Mechanisms of Behavioral Activation (BA)
NA Atlanta, Georgia +2 sites NCT05548244
This trial is looking for adolescents with depression who are aged 15-17. Participants will undergo brain scans before, during, and after treatment with Behavioral Activation therapy to study how their brain responds.
Recruiting
Leucine in Midlife Depression
PHASE2 Atlanta, Georgia NCT06580145
This trial is looking for people with major depression, specifically those in midlife. Participants will take leucine for six weeks to see how it affects their brain and mood compared to another substance.
Recruiting
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
PHASE3 Dothan, Alabama +4 sites NCT06372964
This trial is looking for young people aged 10 to 17 who have bipolar depression. Participants will receive either the study medication or a placebo while their mood is monitored.
Recruiting
Brexanolone Lifting Outcomes Of Moms
PHASE3 Decatur, Georgia +4 sites NCT07822321
This trial is looking for women aged 15 to 45 who are experiencing severe postpartum depression. Participants will take the study drug LPCN 1154A to see if it helps reduce their depressive symptoms and to learn about any side effects.
Recruiting
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
PHASE2 Tucson, Arizona +4 sites NCT06524830
This trial is looking for adults with treatment resistant depression. Participants will receive either a new treatment called VLS-01 Buccal Film or a placebo to see how effective it is.
Recruiting
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
PHASE2 Birmingham, Alabama +4 sites NCT07553637
This trial is looking for adults aged 18 to 75 who have moderate to severe depression that hasn't improved with other treatments. Participants will compare the effects of ALTO-207 with a placebo.
Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NA Birmingham, Alabama +4 sites NCT03887715
This trial is looking for adults with treatment-resistant depression. Participants will receive either active VNS therapy or a control without stimulation to see how it affects their depression over 12 months.
Recruiting
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NA Birmingham, Alabama +4 sites NCT06423430
This trial is looking for adults with treatment resistant depression who have not improved with other treatments. Participants will receive a new type of brain stimulation as part of their care.
Recruiting
The OBSERVE Protocol
N/A Atlanta, Georgia +4 sites NCT06725277
This trial is looking for adults with major depression who are starting or continuing treatment with Spravato or IV ketamine. Participants will help us learn about the effectiveness and safety of these treatments over a 5-year period.
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
PHASE3 Bentonville, Arkansas +4 sites NCT04777357
This trial is looking for young people aged 10 to 17 who have bipolar I disorder and are experiencing depressive episodes. Participants will receive either a study drug called cariprazine or a placebo to see how it affects their mood.
Recruiting
Assessing Improvements in Mood and Sleep Trial
NA Augusta, Georgia +2 sites NCT06639477
This trial is looking for older adults aged 55 and up with depression symptoms and a history of suicidal thoughts or attempts. Participants will undergo interviews, answer questionnaires, and wear a device to monitor sleep for 8 weeks.
Recruiting
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
NA Atlanta, Georgia NCT02604277
This trial is looking for people with Bipolar Disorder who want to improve their mental health and reduce suicidal thoughts. Participants will take part in a 6-week group-based program focused on mental well-being.
Recruiting
Brain Stimulation and Decision-making
NA Atlanta, Georgia NCT04099056
This trial is looking for people with depression and healthy controls to participate in tasks that study decision-making. It involves undergoing brain stimulation while performing game-like tasks in a lab setting.
Recruiting
Inflammation and Depression in People With HIV
PHASE2 Atlanta, Georgia +1 sites NCT05849038
This trial is looking for people with HIV who also have depression and high inflammation. Participants will take either the drug baricitinib or a placebo for 10 weeks and complete various tests and assessments during the study.
Recruiting
Dopaminergic Therapy for Anhedonia - 2
PHASE4 Atlanta, Georgia NCT06075771
This trial is looking for people aged 25 to 55 with depression and high inflammation who feel little joy in life. Participants will take either L-DOPA or a placebo for 8 weeks and will undergo various tests and scans during the study.
Recruiting
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
PHASE3 Tucson, Arizona +4 sites NCT07172516
This trial is looking for adults aged 18 to 74 who are currently experiencing a depressive episode connected to bipolar disorder. Participants will receive either azetukalner or a placebo to see how well it works and its safety.
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
PHASE3 Tucson, Arizona +4 sites NCT07484217
This trial is looking for adults with major depressive disorder and excessive daytime sleepiness symptoms. Participants will first take solriamfetol openly, followed by a period where neither the participant nor the doctor knows if the treatment is the drug or a placebo.
Recruiting
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
PHASE3 Marietta, Georgia +4 sites NCT07716098
This trial is looking for adults with treatment-resistant depression. Participants will compare two doses of esketamine nasal spray with a placebo to see how well it improves their symptoms.
Recruiting
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
PHASE2 Phoenix, Arizona +4 sites NCT07610473
This trial is looking for adults with Major Depressive Disorder who have had at least one previous episode of depression. Participants will receive either the study drug DT-101 or a placebo, and attend the clinic for health checks and questionnaires.
Recruiting
See all 28 Depression trials in Georgia

Where the Depression studies are in Georgia

Research sites running the most studies
  • Emory University, Atlanta7 trials
  • Emory University Hospital, Atlanta4 trials
  • Draig Clinical Site, Decatur2 trials
  • Grady Health System, Atlanta2 trials
  • Psych Atlanta, Marietta2 trials
  • Advanced Discovery Research, Atlanta1 trial
By city

Counts are recruiting studies listing at least one site in Georgia, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Georgia: common questions

How many Depression clinical trials are recruiting in Georgia?
TrialFinder currently lists 28 recruiting Depression clinical trials with study sites in Georgia. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Georgia?
Study sites for the Depression trials listed on this page include Atlanta, Decatur, Augusta, Marietta. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in Georgia?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Georgia also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Georgia?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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