Depression Trials / Trials in Tennessee
12 Recruiting Trials

Clinical Trials
for Depression in Tennessee

12 clinical trials for Depression are currently recruiting participants at study sites in Tennessee. Study-related care is provided at no cost.

12
Recruiting trials
14
Study sites
5
Cities
4
Industry-sponsored
1
Phase 2
4
Phase 3

Depression clinical trials in Tennessee: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Tennessee, recruiting depression studies are concentrated in Nashville, Memphis, Knoxville and Brentwood, with sites in 1 other city. 4 of the 12 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 12 of 12 recruiting Depression trials in Tennessee

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
PHASE3 Milford, Connecticut +4 sites NCT06713616
This trial is looking for adults with depression that hasn't improved with other treatments. Participants will receive either a nasal spray or an IV treatment and help researchers learn how well these options work and how they feel about them.
Recruiting
CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth
NA Nashville, Tennessee NCT05456035
This trial is looking for young people aged 13 to 17 who are experiencing depression. Participants will receive either standard therapy or enhanced therapy that focuses on improving social skills.
Recruiting
Latino Teen Depression Treatment Study
N/A Nashville, Tennessee NCT05499182
This trial is looking for Latino teens with depression and their parents to share their experiences. The goal is to find ways to help more teens get therapy. Participants will take part in discussions and interviews.
Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NA Birmingham, Alabama +4 sites NCT03887715
This trial is looking for adults with treatment-resistant depression. Participants will receive either active VNS therapy or a control without stimulation to see how it affects their depression over 12 months.
Recruiting
The OBSERVE Protocol
N/A Milford, Connecticut +4 sites NCT06725277
This trial is looking for adults with major depression who are starting or continuing treatment with Spravato or IV ketamine. Participants will help us learn about the effectiveness and safety of these treatments over a 5-year period.
Recruiting
NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)
NA Nashville, Tennessee NCT07214597
This trial is looking for mothers of infants in the NICU who are experiencing postpartum depression. Participants will use the VoiceLove app to help improve their mental health during their baby's hospital stay.
Recruiting
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
PHASE3 Tucson, Arizona +4 sites NCT07172516
This trial is looking for adults aged 18 to 74 who are currently experiencing a depressive episode connected to bipolar disorder. Participants will receive either azetukalner or a placebo to see how well it works and its safety.
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
PHASE3 Tucson, Arizona +4 sites NCT07484217
This trial is looking for adults with major depressive disorder and excessive daytime sleepiness symptoms. Participants will first take solriamfetol openly, followed by a period where neither the participant nor the doctor knows if the treatment is the drug or a placebo.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
PHASE2 Phoenix, Arizona +4 sites NCT07621237
This trial is looking for adults with major depressive disorder to see if a new treatment called TNX-102 SL helps improve their symptoms. Participants will take the treatment or a placebo for 6 weeks and visit the clinic every two weeks for checkups.
Recruiting
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
NA Knoxville, Tennessee +1 sites NCT06374277
This trial is looking for patients who have multiple chronic health conditions and are uninsured or on Medicaid. Participants will receive assistance with their medications and coordination of care to help them stay on track after leaving the hospital.
Recruiting
AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study
NA Knoxville, Tennessee NCT07768670
This trial is looking for older adults aged 65 and above who want to improve their physical activity and overall health. Participants will use a smartphone app for guidance on exercise over 8 weeks.
Recruiting
See all 12 Depression trials in Tennessee

Where the Depression studies are in Tennessee

Research sites running the most studies
  • Athena Care, Nashville2 trials
  • Baptist Memorial Hospital and Cancer Center-Memphis, Memphis1 trial
  • Clinical Neuroscience Solutions Inc. - Memphis, Mephis1 trial
  • Clinical Neuroscience Solutions, LLC, Memphis1 trial
  • Clinical Research Site, Memphis1 trial
  • Judy Garber, Nashville1 trial
By city

Counts are recruiting studies listing at least one site in Tennessee, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Tennessee: common questions

How many Depression clinical trials are recruiting in Tennessee?
TrialFinder currently lists 12 recruiting Depression clinical trials with study sites in Tennessee. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Tennessee?
Study sites for the Depression trials listed on this page include Nashville, Knoxville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in Tennessee?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Tennessee also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Tennessee?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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