24 Recruiting Trials

Clinical Trials
for Stroke in Tennessee

24 clinical trials for Stroke are currently recruiting participants at study sites in Tennessee. Study-related care is provided at no cost.

24
Recruiting trials
24
Study sites
6
Cities
15
Industry-sponsored
4
Phase 2
7
Phase 3

Stroke clinical trials in Tennessee: what to expect

Stroke trials come in three kinds. Acute treatment trials enroll within hours of a stroke, inside the hospital, and are not something you apply to. Recovery and rehabilitation trials enroll from a few weeks to many years after a stroke and test intensive therapy, robotics, brain and nerve stimulation, virtual reality and medicines meant to help the brain rewire. Prevention trials test blood thinners, cholesterol and blood pressure treatments and procedures to lower the chance of a second stroke.

In Tennessee, recruiting stroke studies are concentrated in Memphis, Nashville, Chattanooga and Knoxville, with sites in 2 other cities. 15 of the 24 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who stroke trials usually look for

Listings state the time since stroke, the type (a clot or a bleed) and the kind of difficulty they study, such as arm and hand weakness, walking, speech or vision, often with a range on a standard scale that the study therapist scores. Many recovery trials enroll people six months or more after their stroke, so an older stroke does not rule you out. Prevention trials look for a stroke or mini-stroke in a recent window plus a specific risk factor such as atrial fibrillation. Most require that you can give consent and take part in sessions.

What taking part involves

Rehabilitation trials are intensive: several sessions a week for four to twelve weeks, with assessments by a therapist before, after and some months later, and sometimes an MRI. The comparison group often receives standard therapy or the same program later. Prevention trials are long and light: a study medicine or placebo added to usual care, visits every few months for several years. Study care and equipment are free and travel is usually reimbursed; a family member is welcome at visits.

Questions worth asking the study team

How many sessions are required and where; whether a comparison group receives the therapy later; whether current rehabilitation can continue; what the assessments involve; and whether transport can be arranged.

Showing 20 of 24 recruiting Stroke trials in Tennessee

Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
PHASE2 Fairhope, Alabama +4 sites NCT05065216
This trial is looking for adults who have had a moderate stroke and present within 24 hours of the onset. Participants will receive a study medication to see if it helps improve their condition.
Recruiting
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
NA Tucson, Arizona +4 sites NCT03821129
This trial is looking for patients who have had a recent stroke and also have a condition called Patent Foramen Ovale (PFO). Participants will receive a device to help reduce the risk of future strokes.
Recruiting
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
N/A Birmingham, Alabama +4 sites NCT05911568
This trial is looking for adults who had a stroke and have moderate to severe disability before it. Participants will compare two treatment options: a procedure to remove blood clots or regular medical care without the procedure.
Recruiting
Stroke Thrombectomy and Aneurysm Registry
N/A Birmingham, Alabama +4 sites NCT04994756
This trial is looking for patients undergoing surgery for brain injuries. Participants will help collect information about their treatment and outcomes.
Recruiting
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
PHASE3 Mobile, Alabama +4 sites NCT05611242
This trial is looking for adults aged 18 to 79 who have had an acute ischemic stroke. Participants will receive a specific treatment for blocked arteries in the brain to see if it's more effective than other approaches.
Recruiting
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
PHASE2 Long Beach, California +4 sites NCT06990867
This trial is looking for adults with acute ischemic stroke who seek care within 4.5 to 24 hours. Participants will receive either a new treatment called JX10 or a placebo to see how it affects recovery and safety.
Recruiting
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
PHASE3 Tucson, Arizona +4 sites NCT05691244
This trial is looking for adults who have had an acute ischemic stroke. Participants will receive a new treatment called sovateltide along with standard care and will be monitored for safety and effectiveness.
Recruiting
Strategy for Improving Stroke Treatment Response
PHASE2 Birmingham, Alabama +4 sites NCT05948566
This trial is looking for adults who have had a suspected ischemic stroke. Participants will receive a treatment called TS23 to see how safe and effective it is within a specific time after their stroke.
Recruiting
A Study of TAK-755 in Adults With Acute Ischemic Stroke
PHASE2 Scottsdale, Arizona +4 sites NCT07392450
This trial is looking for adults who have had an acute ischemic stroke. Participants will receive a medicine called TAK-755 or a placebo and will be monitored for about 3 months.
Recruiting
A Comparison of Cyclic Manual Direct Aspiration Thrombectomy (Plunger Technique) vs. Static Manual Direct Aspiration Thrombectomy for Treatment of Acute Large Vessel Occlusion Stroke
NA Nashville, Tennessee NCT07231380
This trial is looking for people who have had a stroke caused by a blocked artery. Participants will be assigned to use one of two aspiration techniques to help remove the blockage.
Recruiting
The Pivotal Study of RapidPulseTM Aspiration System
NA Torrance, California +4 sites NCT06029491
This trial is looking for adults aged 18 to 80 who have had a stroke within the last 8 hours. Participants will receive a treatment to remove a blood clot in the brain and will be monitored for 90 days.
Recruiting
Continuous Dual Aspiration Technique With Zoom System for Stroke
N/A Huntsville, Alabama +4 sites NCT07491952
This trial is looking for adults who have had an ischemic stroke. Participants will undergo a specific type of thrombectomy procedure using a new technique.
Recruiting
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
N/A Phoenix, Arizona +4 sites NCT04916210
This trial is looking for adults who have had a stroke and want to help researchers learn more about how strokes affect thinking and memory. Participants will undergo evaluations to understand their recovery and brain health after a stroke.
Recruiting
The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms
NA Phoenix, Arizona +4 sites NCT07143019
This trial is looking for adults with specific types of brain aneurysms who are interested in trying a new device treatment. Participants will need to agree to follow study procedures and provide consent.
Recruiting
Rapid Evacuation and Access of Cerebral Hemorrhage Trial
NA Birmingham, Alabama +4 sites NCT06870812
This trial is looking for adults with a specific type of brain bleed to compare surgery with standard medical care. Participants will receive either surgery to remove blood from the brain or regular medical treatment.
Recruiting
Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA Funnel Catheter
NA Jacksonville, Florida +4 sites NCT06370182
This trial is looking for people who have had a recent stroke caused by a blocked large blood vessel. Participants will undergo a procedure using a special catheter to help restore blood flow to the brain.
Recruiting
Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation
NA Chattanooga, Tennessee +4 sites NCT05723926
This trial is looking for patients with a history of atrial fibrillation and a recent stroke. Participants will receive special implants in addition to their current blood-thinning medication to see if it helps prevent further strokes.
Recruiting
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable
PHASE3 Dothan, Alabama +4 sites NCT07430956
This trial is looking for adults with atrial fibrillation who are unable or choose not to take blood thinners. Participants will take one of two study drugs to see how well they help prevent strokes and blood clots.
Recruiting
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation
PHASE3 Alexander City, Alabama +4 sites NCT07626411
This trial is looking for adults with atrial fibrillation who need treatment to prevent strokes. Participants will receive either the study drug REGN7508 or another medication called apixaban.
Recruiting

Where the Stroke studies are in Tennessee

  • Vanderbilt University Medical Center, Nashville9 trials
  • Methodist University Hospital, Memphis4 trials
  • Fort Sanders Regional Medical Center, Knoxville3 trials
  • Tennessee Center for Clinical Trials, Tullahoma2 trials
  • Baptist Memorial Hospital, Memphis1 trial
  • Baptist Memorial Hospital-Memphis, Memphis1 trial

Counts are recruiting studies listing at least one site in Tennessee, from ClinicalTrials.gov, refreshed every two days.

Stroke clinical trials in Tennessee: common questions

How many Stroke clinical trials are recruiting in Tennessee?
TrialFinder currently lists 24 recruiting Stroke clinical trials with study sites in Tennessee. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Stroke clinical trials located in Tennessee?
Study sites for the Stroke trials listed on this page include Nashville, Knoxville, Chattanooga. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Stroke clinical trial in Tennessee?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Stroke trials in Tennessee also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Stroke clinical trial in Tennessee?
Each study sets its own criteria based on age, Stroke diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
My stroke was years ago. Are there still trials for me?
Yes. Many recovery trials enroll people six months or more after a stroke, and some accept strokes from many years earlier, because they study whether therapy can still improve movement or speech.
What are stroke rehabilitation trials like?
Intensive and hands-on: therapy sessions several times a week for one to three months, sometimes with a device or stimulation added, and assessments before and after. The comparison group usually gets standard therapy or the program at a later date.
Can a family member join a trial if they cannot consent for themselves?
Some trials allow a legally authorized representative to consent on a participant's behalf, particularly acute and prevention studies; most rehabilitation trials need the participant's own consent and active participation. Ask the study team.
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

Check Your Eligibility

Create a free profile and our AI will match you to Stroke trials near you in Tennessee.

Get Matched — Free
No insurance required

Stroke trials cover thrombolytic agents, mechanical thrombectomy techniques, neuroprotective drugs, and intensive rehabilitation programmes for acute and chronic stroke.

All Stroke trials →