50 Recruiting Trials

Clinical Trials
for Obesity in Tennessee

50 clinical trials for Obesity are currently recruiting participants at study sites in Tennessee. Study-related care is provided at no cost.

50
Recruiting trials
51
Study sites
17
Cities
35
Industry-sponsored
9
Phase 2
27
Phase 3

Obesity clinical trials in Tennessee: what to expect

Obesity trials are among the most actively recruiting studies in the United States right now. Most test medicines from the GLP-1 family (the class that includes semaglutide and tirzepatide) or newer compounds that work on the same appetite and blood-sugar pathways, often in people who also have high blood pressure, sleep apnea, knee osteoarthritis or prediabetes. A smaller number study structured diet and exercise programs, devices, or weight-loss surgery.

In Tennessee, recruiting obesity studies are concentrated in Nashville, Knoxville, Memphis and Jackson, with sites in 13 other cities. 35 of the 50 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who obesity trials usually look for

Nearly every study sets a body mass index (BMI) threshold, most often 30 or higher, or 27 or higher when you also have a weight-related condition. Many ask that your weight has been stable for the last three months and that you are not currently using a prescription weight-loss drug. Age limits of 18 to 75 are common. Pregnancy, a history of pancreatitis or certain thyroid cancers, and bariatric surgery within the last few years are the exclusions that come up most.

If you have type 2 diabetes, look for trials that name it: some obesity studies exclude diabetes, while others are designed specifically for people who have both.

What taking part involves

A screening visit with a physical exam, blood work and an ECG usually comes first. Drug trials then run for six months to two years, with study visits every few weeks at the start and every one to three months later on. Most GLP-1 studies use a once-weekly injection you give yourself at home; many are placebo-controlled, meaning some participants receive an inactive version for part or all of the study, and you are told that before you agree to join. Study medication, visits and tests are provided at no cost, and most trials pay a stipend for time and travel.

Questions worth asking the study team

Whether there is a placebo group and how long it lasts; whether you can continue the medicine after the study ends; how many visits are required and how far the site is from you; and what happens if you need to stop early. Sites answer these every day and a ten-minute phone screen is the normal next step.

Showing 20 of 50 recruiting Obesity trials in Tennessee

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
PHASE3 Birmingham, Alabama +4 sites NCT07654374
This trial is looking for adults with obesity or overweight who also have type 2 diabetes. Participants will take either the drug aleniglipron or a placebo for 76 weeks to assess its effects.
Recruiting
Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have Obesity (ADVANCE-SURMOUNT-KIDS)
PHASE3 Tucson, Arizona +4 sites NCT07817875
This trial is looking for children aged 6 to less than 12 years who have obesity. Participants will try a new treatment along with healthy lifestyle changes for about two years.
Recruiting
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
PHASE3 Tucson, Arizona +4 sites NCT06672549
This trial is looking for teens aged 12 to under 18 who are struggling with obesity or being overweight. Participants must have tried losing weight before but were unsuccessful.
Recruiting
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)
PHASE3 Anniston, Alabama +4 sites NCT07684235
This trial is looking for individuals with obesity or overweight who have completed a previous trial. Participants will receive maridebart cafraglutide and be monitored for safety and effectiveness over a longer period.
Recruiting
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
PHASE3 Birmingham, Alabama +4 sites NCT07564414
This trial is looking for people with obesity, with or without type 2 diabetes, who want to lose weight. Participants will be assigned by chance to receive either CagriSema or semaglutide for about 83 weeks.
Recruiting
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
PHASE3 Tuscaloosa, Alabama +4 sites NCT07321886
This trial is looking for adults who are overweight or have obesity but do not have type 2 diabetes. Participants will take eloralintide for a main phase lasting about 75 weeks, with an option to continue for another 2 years if they have prediabetes.
Recruiting
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes
PHASE3 Birmingham, Alabama +4 sites NCT07743450
This trial is looking for adults with obesity or overweight who have type 2 diabetes. Participants will take a daily oral medication to see how well it works and how safe it is over time.
Recruiting
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
PHASE3 Birmingham, Alabama +4 sites NCT07743463
This trial is looking for adults who are overweight or obese and have weight-related health problems. Participants will take a daily pill for the study to see how well it helps with weight management and its safety.
Recruiting
Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
PHASE3 Anniston, Alabama +4 sites NCT07284875
This trial is looking for people who are overweight or living with obesity and have related health issues, but do not have diabetes. Participants will receive a weekly injection of ribupatide or a placebo to see how it affects their weight.
Recruiting
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
PHASE3 Oxnard, California +4 sites NCT06672939
This trial is looking for teenagers who are overweight or have obesity with related health issues. Participants will take a daily medicine called orforglipron or a placebo for about 18 months and may continue receiving treatment afterward.
Recruiting
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
PHASE3 Alexander City, Alabama +4 sites NCT07567001
This trial is looking for individuals with heart failure who are also obese. Participants will receive either an injection of NNC0487-0111 or a placebo once a week to see how well it works and how safe it is.
Recruiting
Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
PHASE3 Birmingham, Alabama +4 sites NCT07654361
This trial is looking for adults with obesity or overweight who have health problems related to their weight. Participants will take a daily medication called aleniglipron for at least 76 weeks while following a reduced-calorie diet and increasing physical activity.
Recruiting
Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
PHASE2 Pelham, Alabama +4 sites NCT07752979
This trial is looking for adults with obesity or overweight who have weight-related health issues. Participants will receive injections of either the study drug ABBV-295 or a placebo for 52 weeks, and their progress will be monitored through regular visits and assessments.
Recruiting
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
PHASE2 Chandler, Arizona +4 sites NCT06143956
This trial is looking for adults who are overweight or have obesity to test different weight management treatments. Participants will be evaluated to see if they can safely join the trial.
Recruiting
Sympathetic Mechanisms in Obesity-Crossover Design
PHASE1 Nashville, Tennessee NCT05312892
This trial is looking for adults with obesity and high blood pressure. Participants will receive either a placebo, amlodipine, or moxonidine for two weeks and will be studied on three occasions to see how these treatments affect glucose production.
Recruiting
Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events
PHASE1 Walnut Creek, California +4 sites NCT07607587
This trial is looking for people with obesity or overweight who can't tolerate certain diabetes medications. Participants will receive either Cagrilintide or a placebo for about 8 months.
Recruiting
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
PHASE1 Knoxville, Tennessee +3 sites NCT07142707
This trial is looking for adults with obesity to test a new treatment called MBX 4291. Participants will receive the treatment through injections to help us understand how safe it is and how it works in the body.
Recruiting
Daily Eating Patterns for Total Health Study
NA Knoxville, Tennessee NCT06455995
Recruiting
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
PHASE3 Anniston, Alabama +4 sites NCT07351045
This trial is looking for adults who are overweight or have obesity without type 2 diabetes. Participants will take a study drug or a placebo to help with weight management and will need to self-administer the treatment.
Recruiting

Where the Obesity studies are in Tennessee

  • Vanderbilt University Medical Center, Nashville8 trials
  • Clinical Research Associates, Nashville3 trials
  • Research Site, Franklin3 trials
  • Vanderbilt Health One Hundred Oaks, Nashville3 trials
  • AMR Clinical, Nashville2 trials
  • Cardiovascular Research of Knoxville North Knoxville Medical Center, Powell2 trials

Counts are recruiting studies listing at least one site in Tennessee, from ClinicalTrials.gov, refreshed every two days.

Obesity clinical trials in Tennessee: common questions

How many Obesity clinical trials are recruiting in Tennessee?
TrialFinder currently lists 50 recruiting Obesity clinical trials with study sites in Tennessee. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Obesity clinical trials located in Tennessee?
Study sites for the Obesity trials listed on this page include Nashville, Knoxville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Obesity clinical trial in Tennessee?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Obesity trials in Tennessee also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Obesity clinical trial in Tennessee?
Each study sets its own criteria based on age, Obesity diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need a BMI over 30 to join an obesity clinical trial?
Most adult obesity trials require a BMI of 30 or higher, or 27 or higher if you also have a weight-related condition such as high blood pressure, prediabetes or sleep apnea. Each trial page lists its exact threshold.
Are obesity trial participants paid?
Study medication, visits and tests are provided free, and most obesity trials pay a stipend per visit for time and travel. The amount is set by each study and told to you before you enroll; it is never contingent on finishing the study.
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Obesity trials study GLP-1 receptor agonists, bariatric procedures, behavioural interventions, and combination weight-loss therapies in adults and adolescents.

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