Hypertension Trials / Trials in Tennessee
40 Recruiting Trials

Clinical Trials
for Hypertension in Tennessee

40 clinical trials for Hypertension are currently recruiting participants at study sites in Tennessee. Study-related care is provided at no cost.

40
Recruiting trials
33
Study sites
6
Cities
17
Industry-sponsored
6
Phase 2
8
Phase 3

Hypertension clinical trials in Tennessee: what to expect

High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.

In Tennessee, recruiting hypertension studies are concentrated in Nashville, Knoxville, Chattanooga and Memphis, with sites in 2 other cities. 17 of the 40 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who hypertension trials usually look for

Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.

What taking part involves

Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.

Showing 20 of 40 recruiting Hypertension trials in Tennessee

Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension
PHASE2 Arvada, Colorado +4 sites NCT07511361
This trial is looking for adults who have recently been hospitalized for severe high blood pressure. Participants will take a medication called tonlamarsen to see how well it lowers their blood pressure.
Recruiting
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
NA Nashville, Tennessee NCT03042988
This trial is looking for patients with autonomic failure who have high blood pressure while lying down. Participants will receive localized heat treatment on their abdomen during the night to see if it lowers their nighttime blood pressure.
Recruiting
Team Lifestyle Immersion Hypertension Control Project
NA Nashville, Tennessee NCT07201948
This trial is looking for people at risk of high blood pressure. Participants will receive support for healthy eating, physical fitness, and managing their health. Follow-up will occur at 3, 6, and 12 months to see how these changes help.
Recruiting
Treatment of Supine Hypertension in Autonomic Failure (CPAP)
NA Nashville, Tennessee NCT03312556
This trial is looking for patients with autonomic failure who also have high blood pressure when lying down. Participants will use continuous positive airway pressure (CPAP) to see if it helps lower their blood pressure.
Recruiting
An Adaptive Program of IKT-001 in Pulmonary Arterial Hypertension (PAH)
PHASE3 Scottsdale, Arizona +4 sites NCT07365332
This trial is looking for adults with a specific type of high blood pressure in the lungs called pulmonary arterial hypertension (PAH). Participants will take IKT-001 and be monitored for its effectiveness and safety.
Recruiting
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
PHASE3 Alexander City, Alabama +4 sites NCT07288398
This trial is looking for adults with pulmonary hypertension and heart failure. Participants will take either a medication called levosimendan or a placebo to see if it improves their walking distance.
Recruiting
Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension
PHASE2 Nashville, Tennessee +2 sites NCT06992440
This trial is looking for adults with pulmonary arterial hypertension (PAH) who have problems with the right side of their heart. Participants will take either the study drug empagliflozin or a placebo while continuing their current PAH treatment.
Recruiting
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
PHASE1 Scottsdale, Arizona +4 sites NCT06649110
This trial is looking for healthy volunteers and patients diagnosed with pulmonary arterial hypertension (PAH). Participants will receive treatment LTP001 and help researchers learn about its effects.
Recruiting
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
PHASE2 Los Angeles, California +4 sites NCT05587712
This trial is looking for children aged 1 to under 18 with pulmonary arterial hypertension (PAH). Participants will receive treatment with sotatercept over 24 weeks to evaluate safety and how the body processes the drug.
Recruiting
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
NA Birmingham, Alabama +4 sites NCT06911632
This trial is looking for adults who are at least 18 years old and have been diagnosed with a specific lung disease. They need to have a certain level of lung function that is low enough, but they can't already have been diagnosed with high blood pressure in the lungs or have certain heart conditions. It's also important that they haven't had a specific heart test in the last year and are generally healthy enough to participate.
Recruiting
The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) Study
NA Nashville, Tennessee NCT05464095
Recruiting
Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension
NA Nashville, Tennessee NCT07563322
This trial is looking for adults with a specific type of serious lung condition called combined pulmonary hypertension. Participants will take a dietary supplement and a placebo at different times to see if it helps improve their health.
Recruiting
Hormonal, Metabolic, and Signaling Interactions in PAH
N/A Nashville, Tennessee NCT01884051
This trial is looking for people with certain types of pulmonary hypertension, including those with family members affected by it. Participants will undergo tests and provide blood samples to help understand the disease better.
Recruiting
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
N/A Birmingham, Alabama +4 sites NCT06388421
This trial is looking for adults with pulmonary hypertension related to interstitial lung disease. Participants will share information about their health and treatments to help improve understanding of these conditions.
Recruiting
Right Ventricle Lipid in Pulmonary Arterial Hypertension (PAH)
N/A Nashville, Tennessee NCT05462574
This trial is looking for adults with certain types of pulmonary arterial hypertension (PAH). Participants will undergo tests like MRIs and exercise assessments to help researchers understand heart health in PAH patients.
Recruiting
Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals
N/A Nashville, Tennessee NCT05584722
Recruiting
Pulmonary Hypertension Association Registry
N/A Phoenix, Arizona +4 sites NCT04071327
This trial is looking for people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Participants will provide information about their health and treatment to help improve care for these conditions.
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
NA Scottsdale, Arizona +4 sites NCT06059638
This trial is looking for people with high blood pressure who need a pacemaker. Participants will try a new treatment that adjusts heart rhythms to help lower blood pressure.
Recruiting
Arterial Stiffness and Blood Pressure
NA Nashville, Tennessee +2 sites NCT06495710
This trial is looking for older veterans who have high blood pressure. Participants will be randomly assigned to different blood pressure treatment methods and will undergo tests to measure their blood vessel stiffness.
Recruiting
Global Paradise System US Post Approval Study
N/A Long Beach, California +4 sites NCT06297291
This trial is looking for adults with high blood pressure that isn't controlled by lifestyle changes or medications. Participants will receive treatment with the Paradise Ultrasound Renal Denervation System and help researchers understand its long-term safety and effectiveness.
Recruiting
See all 40 Hypertension trials in Tennessee

Where the Hypertension studies are in Tennessee

Research sites running the most studies
  • Vanderbilt University Medical Center, Nashville14 trials
  • Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville3 trials
  • Alliance for Multispecialty Research, LLC-Knoxville-69693, Knoxville1 trial
  • Ascension Saint Thomas, Nashville1 trial
  • Ascension St. Thomas Hospital, Nashville1 trial
  • Chattanooga Research & Medicine CHARM, Chattanooga1 trial
By city

Counts are recruiting studies listing at least one site in Tennessee, from ClinicalTrials.gov, refreshed every two days.

Hypertension clinical trials in Tennessee: common questions

How many Hypertension clinical trials are recruiting in Tennessee?
TrialFinder currently lists 40 recruiting Hypertension clinical trials with study sites in Tennessee. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Hypertension clinical trials located in Tennessee?
Study sites for the Hypertension trials listed on this page include Nashville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Hypertension clinical trial in Tennessee?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Hypertension trials in Tennessee also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Hypertension clinical trial in Tennessee?
Each study sets its own criteria based on age, Hypertension diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I stop my blood pressure medicine to join a trial?
Some trials add the study drug to what you take; others standardize or pause your medicines for a few weeks under close monitoring, with rules for stepping in if pressure rises. The listing and consent form state which.
What is ambulatory blood pressure monitoring?
A small cuff and monitor worn for 24 hours that records readings automatically, including during sleep. Trials use it because it is more reliable than clinic readings; the site fits it and you return it the next day.
Is a high reading at home enough to qualify?
It is a reason to ask. Trials confirm eligibility with readings taken at the site after resting, usually on two visits, so a single home reading neither qualifies nor rules you out.
Hypertension Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Hypertension Trials

Hypertension trials study novel antihypertensives, renal denervation, lifestyle interventions, and combination therapies for resistant high blood pressure.

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