30 Recruiting Trials
Clinical Trials
for Hypertension in South Carolina
30 clinical trials for Hypertension are currently recruiting participants at study sites in South Carolina. Study-related care is provided at no cost.
30
Recruiting trials
33
Study sites
14
Cities
24
Industry-sponsored
7
Phase 2
9
Phase 3
Hypertension clinical trials in South Carolina: what to expect
High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.
In South Carolina, recruiting hypertension studies are concentrated in Charleston, Columbia, Anderson and Greenville, with sites in 10 other cities. 24 of the 30 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who hypertension trials usually look for
Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.
What taking part involves
Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.
Questions worth asking the study team
Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.
Showing 20 of 30 recruiting Hypertension trials in South Carolina
Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension
Recruiting
This trial is looking for adults who have recently been hospitalized for severe high blood pressure. Participants will take a medication called tonlamarsen to see how well it lowers their blood pressure.
Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
Recruiting
This trial is looking for people with uncontrolled high blood pressure. Participants will take either the study drug or a placebo to see if it helps lower their blood pressure.
THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
Recruiting
This trial is looking for adults with hypertension who have not been able to control their blood pressure with medication. Participants will stop taking their blood pressure medications for a short time and receive either the TIVUS treatment or a sham procedure.
A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD
Recruiting
This trial is looking for adults with high blood pressure in the lungs caused by lung disease. Participants will take either L606 or a placebo for comparison while doctors monitor their health and side effects.
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
Recruiting
This trial is looking for adults who have completed a previous study with seralutinib. Participants will take seralutinib and be monitored for safety and effectiveness over time.
A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)
Recruiting
This trial is looking for adults with pulmonary arterial hypertension (PAH) who want to try a new inhalation treatment. Participants will take the treatment once a day for 24 weeks and will be monitored for changes in their exercise ability.
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Recruiting
This trial is looking for people who have completed a previous study with sotatercept for pulmonary arterial hypertension (PAH). Participants will be monitored for the long-term safety and tolerance of sotatercept along with their usual PAH treatments.
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
Recruiting
This trial is looking for adults with pulmonary hypertension and heart failure. Participants will take either a medication called levosimendan or a placebo to see if it improves their walking distance.
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
Recruiting
This trial is looking for adults with high blood pressure that is hard to control. Participants will take either the drug RTN-001 or a placebo (a dummy pill) every day for 12 weeks and visit the clinic for checkups.
HS235 Study in Overweight and Obese Participants With Combined Pre and Post-Capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction
Recruiting
This trial is looking for obese adults with pulmonary hypertension and heart failure. Participants will be evaluated for their symptoms and heart function before starting the trial treatment.
A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD
Recruiting
This trial is looking for people with pulmonary hypertension related to lung disease who are already using inhaled treprostinil. Participants will take inhaled mosliciguat to see how safe and tolerable it is in this situation.
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
Recruiting
This trial is looking for adults who are at least 18 years old and have been diagnosed with a specific lung disease. They need to have a certain level of lung function that is low enough, but they can't already have been diagnosed with high blood pressure in the lungs or have certain heart conditions. It's also important that they haven't had a specific heart test in the last year and are generally healthy enough to participate.
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
Recruiting
This trial is looking for adults with pulmonary hypertension and issues with heart function. Participants will be assessed for safety and effectiveness of a specific treatment device.
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Recruiting
This trial is looking for adults with pulmonary hypertension related to interstitial lung disease. Participants will share information about their health and treatments to help improve understanding of these conditions.
An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH
Recruiting
This trial is looking for people with pulmonary hypertension related to interstitial lung disease. Participants will take part in a treatment involving inhaled medication and undergo assessments to monitor their health.
Pulmonary Hypertension Association Registry
Recruiting
This trial is looking for people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Participants will provide information about their health and treatment to help improve care for these conditions.
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
Recruiting
This trial is looking for people with high blood pressure who need a pacemaker. Participants will try a new treatment that adjusts heart rhythms to help lower blood pressure.
Global Paradise System US Post Approval Study
Recruiting
This trial is looking for adults with high blood pressure that isn't controlled by lifestyle changes or medications. Participants will receive treatment with the Paradise Ultrasound Renal Denervation System and help researchers understand its long-term safety and effectiveness.
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
Recruiting
This trial is looking for adults with chronic kidney disease and high blood pressure. If you join, you will take medications to see how they affect your kidney health and heart-related risks.
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
Recruiting
This trial is looking for adults with high blood pressure that is not well controlled and have either a history of heart disease or are at high risk for heart disease. Participants will receive either the study drug, zilebesiran, or a placebo to see if it lowers the risk of serious heart-related events.
Where the Hypertension studies are in South Carolina
Research sites running the most studies
- Medical University of South Carolina, Charleston7 trials
- University of South Carolina, Columbia3 trials
- AnMed Health, Anderson2 trials
- MUSC, Charleston2 trials
- Care Access - Mauldin, Mauldin1 trial
- Clinical Research Site, Charleston1 trial
By city
Counts are recruiting studies listing at least one site in South Carolina, from ClinicalTrials.gov, refreshed every two days.
Hypertension clinical trials in South Carolina: common questions
How many Hypertension clinical trials are recruiting in South Carolina?
TrialFinder currently lists 30 recruiting Hypertension clinical trials with study sites in South Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Hypertension clinical trials located in South Carolina?
Study sites for the Hypertension trials listed on this page include Greenville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Hypertension clinical trial in South Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Hypertension trials in South Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Hypertension clinical trial in South Carolina?
Each study sets its own criteria based on age, Hypertension diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I stop my blood pressure medicine to join a trial?
Some trials add the study drug to what you take; others standardize or pause your medicines for a few weeks under close monitoring, with rules for stepping in if pressure rises. The listing and consent form state which.
What is ambulatory blood pressure monitoring?
A small cuff and monitor worn for 24 hours that records readings automatically, including during sleep. Trials use it because it is more reliable than clinic readings; the site fits it and you return it the next day.
Is a high reading at home enough to qualify?
It is a reason to ask. Trials confirm eligibility with readings taken at the site after resting, usually on two visits, so a single home reading neither qualifies nor rules you out.
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Hypertension Trials
Hypertension trials study novel antihypertensives, renal denervation, lifestyle interventions, and combination therapies for resistant high blood pressure.
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