Hypertension Trials / Trials in Michigan
33 Recruiting Trials

Clinical Trials
for Hypertension in Michigan

33 clinical trials for Hypertension are currently recruiting participants at study sites in Michigan. Study-related care is provided at no cost.

33
Recruiting trials
44
Study sites
19
Cities
24
Industry-sponsored
7
Phase 2
7
Phase 3

Hypertension clinical trials in Michigan: what to expect

High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.

In Michigan, recruiting hypertension studies are concentrated in Detroit, Ann Arbor, Troy and Flint, with sites in 15 other cities. 24 of the 33 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who hypertension trials usually look for

Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.

What taking part involves

Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.

Showing 20 of 33 recruiting Hypertension trials in Michigan

Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension
PHASE2 Detroit, Michigan +4 sites NCT07511361
This trial is looking for adults who have recently been hospitalized for severe high blood pressure. Participants will take a medication called tonlamarsen to see how well it lowers their blood pressure.
Recruiting
SPYRAL GEMINI Pilot Study
NA Stanford, California +4 sites NCT06907147
This trial is looking for people with high blood pressure who are between 18 and 80 years old. Participants will receive a treatment aimed at lowering blood pressure.
Recruiting
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
NA Tucson, Arizona +4 sites NCT07214376
This trial is looking for patients with heart failure and pulmonary hypertension. Participants will receive a specific treatment and be monitored for three years to evaluate safety and effectiveness.
Recruiting
AM vs PM Exercise Training
NA East Lansing, Michigan NCT06042439
This trial is looking for postmenopausal women aged 55 to 80 with high blood pressure. Participants will do exercise training either in the morning or early evening to see how it affects their blood pressure and blood vessel health.
Recruiting
THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
NA Birmingham, Alabama +4 sites NCT06559891
This trial is looking for adults with hypertension who have not been able to control their blood pressure with medication. Participants will stop taking their blood pressure medications for a short time and receive either the TIVUS treatment or a sham procedure.
Recruiting
Reach Out 2: Emergency Department-Initiated Hypertension Mobile Health Intervention Connecting Multiple Health Systems
NA Flint, Michigan NCT06391073
This trial is looking for adults with high blood pressure who visit the emergency department. Participants will use a mobile health program to help lower their blood pressure and improve their overall health.
Recruiting
The RADIANCE CED Study
N/A Detroit, Michigan +1 sites NCT07231757
This trial is looking for adults aged 65 and older who have high blood pressure that is hard to control. Participants will be monitored to see how well ultrasound treatment helps lower their blood pressure over time.
Recruiting
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
PHASE3 Fresno, California +4 sites NCT06274801
This trial is looking for adults who have completed a previous study with seralutinib. Participants will take seralutinib and be monitored for safety and effectiveness over time.
Recruiting
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
PHASE3 Alexander City, Alabama +4 sites NCT07288398
This trial is looking for adults with pulmonary hypertension and heart failure. Participants will take either a medication called levosimendan or a placebo to see if it improves their walking distance.
Recruiting
A Study of ROC-101 in Patients With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (ILD-PH) (ROCSTAR STUDY)
PHASE2 Phoenix, Arizona +4 sites NCT07175038
This trial is looking for adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension related to interstitial lung disease (ILD-PH). Participants will receive standard care plus ROC-101 for 24 weeks, followed by a longer extension period based on the study's progress.
Recruiting
To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension
PHASE2 Little Rock, Arkansas +4 sites NCT06343298
This trial is looking for adults aged 18 to 80 who have high blood pressure that is hard to manage. Participants will receive either a treatment called MANP or a placebo to see if it helps lower their blood pressure.
Recruiting
Study of TX000045 in Participants With Pulmonary Hypertension Due to Interstitial Lung Disease
PHASE2 Allen Park, Michigan +4 sites NCT07473700
This trial is looking for participants with pulmonary hypertension related to interstitial lung disease. Taking part involves assessing the effects and safety of a treatment called TX000045.
Recruiting
A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD
PHASE2 Santa Barbara, California +4 sites NCT07333183
This trial is looking for people with pulmonary hypertension related to lung disease who are already using inhaled treprostinil. Participants will take inhaled mosliciguat to see how safe and tolerable it is in this situation.
Recruiting
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
NA Birmingham, Alabama +4 sites NCT06911632
This trial is looking for adults who are at least 18 years old and have been diagnosed with a specific lung disease. They need to have a certain level of lung function that is low enough, but they can't already have been diagnosed with high blood pressure in the lungs or have certain heart conditions. It's also important that they haven't had a specific heart test in the last year and are generally healthy enough to participate.
Recruiting
Early Feasibility Study of "HyperQureTM RDN System", Laparoscopic Renal Denervation Therapy, in Patients With Resistant Hypertension
NA Detroit, Michigan +4 sites NCT06526858
This trial is looking for adults aged 22 to 80 with resistant hypertension. Participants will undergo a procedure to evaluate a new renal denervation device while continuing their current blood pressure medications.
Recruiting
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
N/A Birmingham, Alabama +4 sites NCT06388421
This trial is looking for adults with pulmonary hypertension related to interstitial lung disease. Participants will share information about their health and treatments to help improve understanding of these conditions.
Recruiting
An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH
N/A Phoenix, Arizona +4 sites NCT06129240
This trial is looking for people with pulmonary hypertension related to interstitial lung disease. Participants will take part in a treatment involving inhaled medication and undergo assessments to monitor their health.
Recruiting
Pulmonary Hypertension Association Registry
N/A Phoenix, Arizona +4 sites NCT04071327
This trial is looking for people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Participants will provide information about their health and treatment to help improve care for these conditions.
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
NA Scottsdale, Arizona +4 sites NCT06059638
This trial is looking for people with high blood pressure who need a pacemaker. Participants will try a new treatment that adjusts heart rhythms to help lower blood pressure.
Recruiting
Addressing Cardiometabolic Health In Populations Through Early Prevention in the Great Lakes Region Project 1 - Epidemiology (ACHIEVE P1-EPI)
NA Detroit, Michigan NCT06593496
This trial is looking for patients with high blood pressure who visit the Mobile Health Unit. Participants will help researchers understand health factors related to blood pressure and follow-up care.
Recruiting
See all 33 Hypertension trials in Michigan

Where the Hypertension studies are in Michigan

Research sites running the most studies
  • Henry Ford Hospital, Detroit6 trials
  • University of Michigan, Ann Arbor6 trials
  • Aa Mrc Llc, Flint2 trials
  • Henry Ford Health, Detroit2 trials
  • Henry Ford Providence Hospital, Southfield2 trials
  • Henry Ford St. John Hospital, Detroit2 trials
By city

Counts are recruiting studies listing at least one site in Michigan, from ClinicalTrials.gov, refreshed every two days.

Hypertension clinical trials in Michigan: common questions

How many Hypertension clinical trials are recruiting in Michigan?
TrialFinder currently lists 33 recruiting Hypertension clinical trials with study sites in Michigan. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Hypertension clinical trials located in Michigan?
Study sites for the Hypertension trials listed on this page include Detroit, East Lansing, Flint, Allen Park. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Hypertension clinical trial in Michigan?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Hypertension trials in Michigan also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Hypertension clinical trial in Michigan?
Each study sets its own criteria based on age, Hypertension diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I stop my blood pressure medicine to join a trial?
Some trials add the study drug to what you take; others standardize or pause your medicines for a few weeks under close monitoring, with rules for stepping in if pressure rises. The listing and consent form state which.
What is ambulatory blood pressure monitoring?
A small cuff and monitor worn for 24 hours that records readings automatically, including during sleep. Trials use it because it is more reliable than clinic readings; the site fits it and you return it the next day.
Is a high reading at home enough to qualify?
It is a reason to ask. Trials confirm eligibility with readings taken at the site after resting, usually on two visits, so a single home reading neither qualifies nor rules you out.
Hypertension Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Hypertension Trials

Hypertension trials study novel antihypertensives, renal denervation, lifestyle interventions, and combination therapies for resistant high blood pressure.

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