62 Recruiting Trials
Clinical Trials
for Hypertension in California
62 clinical trials for Hypertension are currently recruiting participants at study sites in California. Study-related care is provided at no cost.
62
Recruiting trials
175
Study sites
64
Cities
40
Industry-sponsored
12
Phase 2
15
Phase 3
Hypertension clinical trials in California: what to expect
High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.
In California, recruiting hypertension studies are concentrated in Los Angeles, San Francisco, Sacramento and Stanford, with sites in 60 other cities. 40 of the 62 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who hypertension trials usually look for
Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.
What taking part involves
Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.
Questions worth asking the study team
Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.
Showing 20 of 62 recruiting Hypertension trials in California
A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran
Recruiting
This trial is looking for adults with mild to moderate high blood pressure. Participants will be evaluated to see how well they respond to the treatment after using another medication called zilebesiran.
Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
Recruiting
This trial is looking for people with uncontrolled high blood pressure. Participants will take either the study drug or a placebo to see if it helps lower their blood pressure.
SPYRAL GEMINI Pilot Study
Recruiting
This trial is looking for people with high blood pressure who are between 18 and 80 years old. Participants will receive a treatment aimed at lowering blood pressure.
THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
Recruiting
This trial is looking for adults with hypertension who have not been able to control their blood pressure with medication. Participants will stop taking their blood pressure medications for a short time and receive either the TIVUS treatment or a sham procedure.
Effect of Electro-Acupuncture on Blood Pressure
Recruiting
This trial is looking for people with high blood pressure to test the effects of electro-acupuncture. Participants may take part whether they are on blood pressure medication or not.
REFOCUS-HTN US-WEST: A Data Infrastructure to Characterize Individuals With Hypertension
Recruiting
This trial is looking for adults with high blood pressure to help researchers learn more about a hormone called aldosterone. Participants will be selected from an existing group of patients who have been diagnosed with hypertension.
Oura Blood Pressure Profile Study
Recruiting
This trial is looking for adult users of the Oura Ring who want to help evaluate a new algorithm for detecting high blood pressure. Participants will use their Oura Ring and app during the study.
A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD
Recruiting
This trial is looking for adults with high blood pressure in the lungs caused by lung disease. Participants will take either L606 or a placebo for comparison while doctors monitor their health and side effects.
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
Recruiting
This trial is looking for adults who have completed a previous study with seralutinib. Participants will take seralutinib and be monitored for safety and effectiveness over time.
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Recruiting
This trial is looking for adults with pulmonary hypertension linked to interstitial lung disease. Participants will take either a study drug called TPIP or a placebo once a day for 24 weeks and will be monitored for their exercise ability.
A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)
Recruiting
This trial is looking for adults with pulmonary arterial hypertension (PAH) who want to try a new inhalation treatment. Participants will take the treatment once a day for 24 weeks and will be monitored for changes in their exercise ability.
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Recruiting
This trial is looking for people who have completed a previous study with sotatercept for pulmonary arterial hypertension (PAH). Participants will be monitored for the long-term safety and tolerance of sotatercept along with their usual PAH treatments.
An Adaptive Program of IKT-001 in Pulmonary Arterial Hypertension (PAH)
Recruiting
This trial is looking for adults with a specific type of high blood pressure in the lungs called pulmonary arterial hypertension (PAH). Participants will take IKT-001 and be monitored for its effectiveness and safety.
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
Recruiting
This trial is looking for adults with pulmonary hypertension and heart failure. Participants will take either a medication called levosimendan or a placebo to see if it improves their walking distance.
A Study of ROC-101 in Patients With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (ILD-PH) (ROCSTAR STUDY)
Recruiting
This trial is looking for adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension related to interstitial lung disease (ILD-PH). Participants will receive standard care plus ROC-101 for 24 weeks, followed by a longer extension period based on the study's progress.
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
Recruiting
This trial is looking for adults with high blood pressure that is hard to control. Participants will take either the drug RTN-001 or a placebo (a dummy pill) every day for 12 weeks and visit the clinic for checkups.
To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension
Recruiting
This trial is looking for adults aged 18 to 80 who have high blood pressure that is hard to manage. Participants will receive either a treatment called MANP or a placebo to see if it helps lower their blood pressure.
Study of TX000045 in Participants With Pulmonary Hypertension Due to Interstitial Lung Disease
Recruiting
This trial is looking for participants with pulmonary hypertension related to interstitial lung disease. Taking part involves assessing the effects and safety of a treatment called TX000045.
A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD
Recruiting
This trial is looking for people with pulmonary hypertension related to lung disease who are already using inhaled treprostinil. Participants will take inhaled mosliciguat to see how safe and tolerable it is in this situation.
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Recruiting
This trial is looking for healthy volunteers and patients diagnosed with pulmonary arterial hypertension (PAH). Participants will receive treatment LTP001 and help researchers learn about its effects.
Where the Hypertension studies are in California
Research sites running the most studies
- Cedars-Sinai Medical Center, Los Angeles3 trials
- University of California, San Francisco, San Francisco3 trials
- Downtown L A Research Center Inc, Los Angeles2 trials
- Orange County Research Center, Lake Forest2 trials
- Stanford University, Stanford2 trials
- Susan Samueli Integrative Health Institute, Irvine2 trials
By city
Counts are recruiting studies listing at least one site in California, from ClinicalTrials.gov, refreshed every two days.
Hypertension clinical trials in California: common questions
How many Hypertension clinical trials are recruiting in California?
TrialFinder currently lists 62 recruiting Hypertension clinical trials with study sites in California. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Hypertension clinical trials located in California?
Study sites for the Hypertension trials listed on this page include Lake Forest, Chula Vista, Stanford, Los Angeles, Irvine, Oakland. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Hypertension clinical trial in California?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Hypertension trials in California also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Hypertension clinical trial in California?
Each study sets its own criteria based on age, Hypertension diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I stop my blood pressure medicine to join a trial?
Some trials add the study drug to what you take; others standardize or pause your medicines for a few weeks under close monitoring, with rules for stepping in if pressure rises. The listing and consent form state which.
What is ambulatory blood pressure monitoring?
A small cuff and monitor worn for 24 hours that records readings automatically, including during sleep. Trials use it because it is more reliable than clinic readings; the site fits it and you return it the next day.
Is a high reading at home enough to qualify?
It is a reason to ask. Trials confirm eligibility with readings taken at the site after resting, usually on two visits, so a single home reading neither qualifies nor rules you out.
Hypertension Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Hypertension Trials
Hypertension trials study novel antihypertensives, renal denervation, lifestyle interventions, and combination therapies for resistant high blood pressure.
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