Understanding Aldosterone's Role in Hypertension

REFOCUS-HTN US-WEST: A Data Infrastructure to Characterize Individuals With Hypertension

Recruiting Observational Study
Hypertension Aldosterone Disorder Cardiovascular Disease (CVD)
No Placebo Group Every participant receives an active treatment — no one gets a placebo. No Study Drug Researchers observe your health over time — no experimental treatment is given.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
500 (estimated)
Sponsor
Kaiser Permanente · Other
Who this trial is looking for

This trial is looking for adults with high blood pressure to help researchers learn more about a hormone called aldosterone. Participants will be selected from an existing group of patients who have been diagnosed with hypertension.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am at least 18 years old
  • I have been diagnosed with hypertension
  • My hypertension diagnosis was within the last 18 months
  • I have health insurance coverage for at least 6 months before starting

You may not be able to join if

  • I have secondary hypertension caused by drugs, alcohol, or kidney issues
  • I had bariatric surgery or received GLP1 prescription in the last year
  • I have used aldosterone synthase inhibitors or mineralocorticoid receptor antagonists in the last 12 weeks
  • My last kidney function test showed an estimated glomerular filtration rate below 45
  • I have had a kidney transplant
  • I am currently undergoing dialysis
  • I am enrolled in another trial for heart or blood pressure treatment

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

The goal of the REFOCUS-HTN US-WEST program is to gain a better understanding of the role of a hormone called aldosterone in the development of hypertension. The SCALED sub-study is an observational cohort study that will enroll from REFOCUS-HTN cohort for prospective data collection.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: The SCALED Cohort will be identified from the REFOCUS-HTN Cohort which includes men and women ≥ 18 years of age with established hypertension in the KPNC EHR from January 2012 through March 31, 2029. Established hypertension will be defined as one of the following: * ≥1 outpati…
Contacts

Ankeet S Bhatt, MD, MBA, ScM

415-470-6571

Ankeet.S.Bhatt@kp.org

CONTACT

Mirasol M Apostol-Largeteau, MPH

415-407-1754

Mirasol.M.Apostol-Largeteau@kp.org

CONTACT