No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
500 (estimated)
Sponsor
Kaiser Permanente · Other
Who this trial is looking for
This trial is looking for adults with high blood pressure to help researchers learn more about a hormone called aldosterone. Participants will be selected from an existing group of patients who have been diagnosed with hypertension.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old
I have been diagnosed with hypertension
My hypertension diagnosis was within the last 18 months
I have health insurance coverage for at least 6 months before starting
You may not be able to join if
I have secondary hypertension caused by drugs, alcohol, or kidney issues
I had bariatric surgery or received GLP1 prescription in the last year
I have used aldosterone synthase inhibitors or mineralocorticoid receptor antagonists in the last 12 weeks
My last kidney function test showed an estimated glomerular filtration rate below 45
I have had a kidney transplant
I am currently undergoing dialysis
I am enrolled in another trial for heart or blood pressure treatment
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of the REFOCUS-HTN US-WEST program is to gain a better understanding of the role of a hormone called aldosterone in the development of hypertension. The SCALED sub-study is an observational cohort study that will enroll from REFOCUS-HTN cohort for prospective data collection.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
The SCALED Cohort will be identified from the REFOCUS-HTN Cohort which includes men and women ≥ 18 years of age with established hypertension in the KPNC EHR from January 2012 through March 31, 2029. Established hypertension will be defined as one of the following:
* ≥1 outpati…
Inclusion Criteria:
The SCALED Cohort will be identified from the REFOCUS-HTN Cohort which includes men and women ≥ 18 years of age with established hypertension in the KPNC EHR from January 2012 through March 31, 2029. Established hypertension will be defined as one of the following:
* ≥1 outpatient, non-emergency department diagnosis of hypertension;
* ≥2 consecutive outpatient measures of systolic blood pressure ≥130 mmHg at least 90 days apart;
* ≥2 consecutive outpatient measures of diastolic blood pressure ≥80 mmHg at least 90 days apart.
Additional Eligibility Criteria for SCALED:
* Hypertension diagnosis within the past 18 months prior to screening.
* At least 6 months of continuous health plan coverage prior to initial visit.
Exclusion Criteria:
* Diagnosed cause of secondary hypertension from drug or alcohol induced, or renovascular hypertension;
* Bariatric surgery or GLP1 prescription in the last 12 months;
* Exposure to an aldosterone synthase inhibitor or a mineralocorticoid receptor antagonist in the last 12 weeks;
* Last known estimated glomerular filtration rate \< 45 mL/min/1.73m2 (according to the CKD-EPI equation) at the time of screening;
* Kidney transplant;
* Currently receiving dialysis;
* Current enrollment in any cardiovascular or blood pressure interventional trial.
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