Heart Disease Trials / Trials in California
40 Recruiting Trials

Clinical Trials
for Heart Disease in California

40 clinical trials for Heart Disease are currently recruiting participants at study sites in California. Study-related care is provided at no cost.

40
Recruiting trials
58
Study sites
17
Cities
15
Industry-sponsored
3
Phase 2
3
Phase 3

Heart Disease clinical trials in California: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In California, recruiting heart disease studies are concentrated in Los Angeles, San Francisco, San Diego and Stanford, with sites in 13 other cities. 15 of the 40 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 20 of 40 recruiting Heart Disease trials in California

Heart Disease of the Small Arteries in Women and Men
NA Los Angeles, California NCT00573027
This trial is looking for women and men who have chest pain and related heart symptoms. Participants will help us understand a specific type of heart disease that is often not diagnosed.
Recruiting
BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
NA Los Angeles, California +4 sites NCT07582848
This trial is looking for mothers and their infants who have been diagnosed with congenital heart disease. Participants will receive support to help increase direct breastfeeding.
Recruiting
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
NA Los Angeles, California +4 sites NCT07582861
This trial is looking for pregnant individuals or mothers of infants diagnosed with congenital heart disease (CHD). Participants will receive usual care plus a virtual psychological intervention to help manage their situation.
Recruiting
Cord Clamping Among Neonates With Congenital Heart Disease
NA Los Angeles, California +4 sites NCT06153459
This trial is looking for pregnant individuals whose babies have been diagnosed with congenital heart disease. Participants will be randomly assigned to have their baby's umbilical cord clamped either 30 seconds or 120 seconds after birth and will complete assessments at various ages to monitor outcomes.
Recruiting
Improving Congenital Heart Disease Care
NA San Francisco, California NCT06581484
This trial is looking for adults with congenital heart disease who want to improve their ability to manage their healthcare. Participants will use a digital tool to gain confidence and support regarding their condition.
Recruiting
The Sequencing for Detection in Congenital Heart Disease (SD-CHD) Study
NA San Diego, California NCT06244940
This trial is looking for pregnant individuals whose unborn baby has been diagnosed with congenital heart disease. By participating, you can help researchers learn more about genetic causes of this condition and how to plan for your baby's care.
Recruiting
Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures
N/A Los Angeles, California +4 sites NCT04604418
This trial is looking for children and young adults with congenital heart disease who are undergoing non-cardiac procedures. Participants will help researchers understand the risks and healthcare needs for these patients.
Recruiting
Lumason® Infusion vs. Bolus Administrations
PHASE3 West Hills, California +4 sites NCT06400004
This trial is looking for adults with heart health issues to compare two ways of giving a heart imaging substance called Lumason®. Participants will receive either a continuous drip or a quick injection of Lumason®.
Recruiting
Gauging Outcomes of Total Milk Ingestion on Lipid and gControl
NA San Francisco, California NCT07087184
This trial is looking for adults who drink milk daily to compare the effects of whole milk versus skim milk on heart health. Participants will switch between these types of milk and share their health information.
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NA Los Angeles, California +4 sites NCT04124120
This trial is looking for women aged 18 and older who need heart surgery. Participants will help researchers compare two types of artery grafts used in heart operations to see which works better.
Recruiting
MyGeneRank: A Digital Platform for Next-Generation Genetic Studies
NA La Jolla, California NCT03277365
This trial is looking for people who use 23andMe and have an Apple mobile device. Participants will share their genetic data to help researchers understand how genetic risk can impact health decisions.
Recruiting
Abbott Structural Heart Device Registry
N/A Los Angeles, California +4 sites NCT06590467
This trial is looking for patients who need or have had heart device implants. Participants will help gather information about the safety and performance of specific heart devices used in hospitals.
Recruiting
Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis
NA Los Angeles, California +4 sites NCT04843072
Recruiting
Thiamine Intervention and Coronary Artery Bypass Grafting
EARLY_PHASE1 Los Angeles, California NCT06326996
This trial is looking for patients with coronary heart disease who are scheduled for bypass surgery. It focuses on understanding if thiamine can help with memory problems that sometimes occur after the surgery.
Recruiting
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
PHASE3 Los Angeles, California +4 sites NCT05918211
This trial is looking for adolescents aged 12 to under 19 who have had the Fontan procedure. Participants will take either udenafil or a placebo to help assess its safety and effectiveness.
Recruiting
Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study
NA Los Angeles, California +4 sites NCT07114718
This trial is looking for infants under 6 months who have a congenital heart defect that needs a special stent to help blood flow. Parents or legal representatives will need to give consent for their child to participate.
Recruiting
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
NA San Francisco, California +4 sites NCT06854458
This trial is looking for people who experience chest pain or shortness of breath to find out if these symptoms are due to a heart issue. Participants will undergo a special heart imaging test during exercise-like conditions to measure blood flow to the heart.
Recruiting
Autus Valve Continued Access Study (CAS)
NA Los Angeles, California +4 sites NCT07466745
This trial is looking for children aged 18 months to 16 years who need surgery to replace their pulmonary valve. Participants will have regular check-ups over 10 years to see how well the Autus Valve works as they grow.
Recruiting
Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements
NA Davis, California +2 sites NCT05637814
This trial is looking for newborns under 22 days old who might have heart issues. Participants will undergo a special screening test to check for critical congenital heart disease.
Recruiting
Parent Navigator Program (PNP) to Improve Outcomes in Latino/x Children and Parents
NA Los Angeles, California NCT07023367
Recruiting
See all 40 Heart Disease trials in California

Where the Heart Disease studies are in California

Research sites running the most studies
  • Cedars-Sinai Medical Center, Los Angeles4 trials
  • Children's Hospital Los Angeles, Los Angeles4 trials
  • Children's Hospital of Los Angeles, Los Angeles3 trials
  • Rady Children's Hospital, San Diego2 trials
  • Stanford University, Stanford2 trials
  • University of California, Los Angeles, Los Angeles2 trials
By city

Counts are recruiting studies listing at least one site in California, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in California: common questions

How many Heart Disease clinical trials are recruiting in California?
TrialFinder currently lists 40 recruiting Heart Disease clinical trials with study sites in California. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in California?
Study sites for the Heart Disease trials listed on this page include Los Angeles, San Francisco, San Diego, West Hills, La Jolla, Davis. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in California?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in California also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in California?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
Alabama Alaska Arizona Arkansas Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

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