Heart Disease Trials / Trials in Missouri
16 Recruiting Trials

Clinical Trials
for Heart Disease in Missouri

16 clinical trials for Heart Disease are currently recruiting participants at study sites in Missouri. Study-related care is provided at no cost.

16
Recruiting trials
17
Study sites
3
Cities
7
Industry-sponsored
1
Phase 2
2
Phase 3

Heart Disease clinical trials in Missouri: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In Missouri, recruiting heart disease studies are concentrated in St Louis, Kansas City and Columbia. 7 of the 16 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 16 of 16 recruiting Heart Disease trials in Missouri

BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
NA Phoenix, Arizona +4 sites NCT07582848
This trial is looking for mothers and their infants who have been diagnosed with congenital heart disease. Participants will receive support to help increase direct breastfeeding.
Recruiting
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
NA Phoenix, Arizona +4 sites NCT07582861
This trial is looking for pregnant individuals or mothers of infants diagnosed with congenital heart disease (CHD). Participants will receive usual care plus a virtual psychological intervention to help manage their situation.
Recruiting
Cord Clamping Among Neonates With Congenital Heart Disease
NA Birmingham, Alabama +4 sites NCT06153459
This trial is looking for pregnant individuals whose babies have been diagnosed with congenital heart disease. Participants will be randomly assigned to have their baby's umbilical cord clamped either 30 seconds or 120 seconds after birth and will complete assessments at various ages to monitor outcomes.
Recruiting
Remote Cardiac Rehab for Adolescents With Congenital Heart Disease
NA Kansas City, Missouri NCT06015191
This trial is looking for teenagers aged 12 to 19 with congenital heart disease. Participants will join live exercise sessions at home for 45 minutes, 3 days a week, over 12 weeks, supervised by a health coach through video calls.
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NA Los Angeles, California +4 sites NCT04124120
This trial is looking for women aged 18 and older who need heart surgery. Participants will help researchers compare two types of artery grafts used in heart operations to see which works better.
Recruiting
Abbott Structural Heart Device Registry
N/A St Louis, Missouri +4 sites NCT06590467
This trial is looking for patients who need or have had heart device implants. Participants will help gather information about the safety and performance of specific heart devices used in hospitals.
Recruiting
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
PHASE3 Phoenix, Arizona +4 sites NCT05918211
This trial is looking for adolescents aged 12 to under 19 who have had the Fontan procedure. Participants will take either udenafil or a placebo to help assess its safety and effectiveness.
Recruiting
A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study
NA Stanford, California +4 sites NCT07525843
This trial is looking for teens aged 12-17 with congenital heart disease. Participants will take part in a 5-week online program that aims to help them improve their ability to handle stress and live better lives.
Recruiting
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
N/A Birmingham, Alabama +4 sites NCT02852031
This trial is looking for newborns diagnosed with Hypoplastic Left Heart Syndrome (HLHS) who are meant to have a specific heart surgery called the Norwood procedure. The goal is to gather information to help improve care for these infants.
Recruiting
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
PHASE3 La Jolla, California +4 sites NCT06563895
This trial is looking for adults who carry a specific genetic variant that can lead to a heart condition but have not yet shown any symptoms. Participants will receive an experimental drug called acoramidis to see if it can prevent heart issues.
Recruiting
Transition to KPL-387 Monotherapy Dosing & Administration Study
PHASE2 Phoenix, Arizona +4 sites NCT07288216
This trial is looking for adults who have a recent history of well-controlled recurring chest pain caused by inflammation around the heart. They should have been treated with certain medications for at least three months and currently be stable on those treatments. However, people with certain infections, recent serious illnesses, or specific other health issues are not eligible to join.
Recruiting
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NA Birmingham, Alabama +4 sites NCT06310031
This trial is looking for adults with advanced heart failure to test a device called the BrioVAD System. Participants will receive the BrioVAD and be monitored for safety and effectiveness compared to another treatment.
Recruiting
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NA Phoenix, Arizona +4 sites NCT06526195
This trial is looking for patients with advanced heart failure who are not dependent on intravenous medications. Participants will be evaluated to see if a device called HeartMate 3 can help their heart function better compared to standard medical treatments.
Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NA Gilbert, Arizona +4 sites NCT03142152
This trial is looking for individuals with heart failure and a specific type of mitral valve problem. Participants will be randomly assigned to receive either the treatment or a control and will need to attend follow-up visits.
Recruiting
CTSN Embolic Protection Trial
NA North Little Rock, Arkansas +4 sites NCT06027788
This trial is looking for patients aged 60 and older who are scheduled for certain types of heart valve surgeries. By participating, I would be helping to test a device designed to protect the heart during the procedure.
Recruiting
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
N/A Columbia, Missouri NCT07083557
This trial is looking for healthy adults or those with certain chronic conditions to help test the accuracy of lab tests and other techniques. Participation involves undergoing tests to see if results are consistent over time.
Recruiting
See all 16 Heart Disease trials in Missouri

Where the Heart Disease studies are in Missouri

Research sites running the most studies
  • Washington University School of Medicine, St Louis4 trials
  • Children's Mercy Hospital, Kansas City2 trials
  • Washington University in St. Louis, St Louis2 trials
  • Children's Mercy Hospital Kansas City, Kansas City1 trial
  • Children's Mercy Hospitals and Clinics, Kansas City1 trial
  • Children's Mercy Kansas City, Kansas City1 trial
By city

Counts are recruiting studies listing at least one site in Missouri, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in Missouri: common questions

How many Heart Disease clinical trials are recruiting in Missouri?
TrialFinder currently lists 16 recruiting Heart Disease clinical trials with study sites in Missouri. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in Missouri?
Study sites for the Heart Disease trials listed on this page include Kansas City, St Louis, Columbia. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in Missouri?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in Missouri also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in Missouri?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

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