52 Recruiting Trials

Clinical Trials
for Diabetes in Missouri

52 clinical trials for Diabetes are currently recruiting participants at study sites in Missouri. Study-related care is provided at no cost.

52
Recruiting trials
47
Study sites
8
Cities
28
Industry-sponsored
8
Phase 2
20
Phase 3

Diabetes clinical trials in Missouri: what to expect

Diabetes is one of the largest areas of clinical research, and the trials differ a great deal by type. Type 2 studies most often test new glucose-lowering or weight-reducing medicines, once-weekly insulins, and combinations with GLP-1 drugs, in people whose A1c is above goal on their current treatment. Type 1 studies test automated insulin delivery systems, immune therapies for people recently diagnosed or at high risk, and cell-based approaches. Others focus on the complications: kidney disease, eye disease, nerve pain and foot ulcers.

In Missouri, recruiting diabetes studies are concentrated in Kansas City, St Louis, Columbia and Jefferson City, with sites in 4 other cities. 28 of the 52 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who diabetes trials usually look for

Type 2 trials typically ask for a confirmed diagnosis, an A1c in a stated range (often between 7 and 10.5 percent) and a stable dose of your current medicines for at least a few months. Many exclude recent insulin use, a recent heart attack or stroke, or kidney function below a cut-off. Type 1 trials are often limited by time since diagnosis and by age, and some enroll children and teenagers with a parent's consent.

You do not need to know your A1c or kidney numbers to ask about a trial; the site measures them at screening.

What taking part involves

Screening includes blood work and a review of your history. Medicine trials usually last six months to three years with visits every one to three months, and many provide a glucose monitor and supplies for the duration. Some compare a new drug with a standard one rather than a placebo, so everyone receives active treatment; others include a placebo arm, and the consent form says which. Study drugs, devices, visits and labs are provided at no cost, and most trials pay for time and travel.

Questions worth asking the study team

Whether you would stay on your current medicines; whether there is a placebo group; how often visits are and whether any can be done remotely; and whether your own doctor will receive the results of study labs. If you have type 1 diabetes, ask whether the study uses your own pump or monitor.

Showing 20 of 52 recruiting Diabetes trials in Missouri

Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
N/A St Louis, Missouri +1 sites NCT05277558
This trial is looking for young people aged 12 to 19 who have a normal weight, are overweight, or have obesity and are at risk for type 2 diabetes. Participants will undergo brain scans and cognitive tests to help understand how weight and blood sugar levels affect brain health.
Recruiting
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
PHASE3 Anniston, Alabama +4 sites NCT07064473
This trial is looking for adults with type 2 diabetes, high blood pressure, and heart disease. Participants will take either the study medication or a placebo daily for up to 4 years.
Recruiting
A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
PHASE3 Birmingham, Alabama +4 sites NCT07754461
This trial is looking for adults with type 2 diabetes who want to try a new medicine called survodutide to help control their blood sugar levels. Participants will receive either the medicine or a placebo and will continue their usual diabetes treatments over about 14 months with regular check-ins.
Recruiting
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
PHASE3 Scottsdale, Arizona +4 sites NCT07088068
This trial is looking for young people ages 1 to 25 who have recently been diagnosed with stage 3 type 1 diabetes. Participants will receive either teplizumab or a placebo through an IV to see how it affects their blood sugar control over 52 weeks.
Recruiting
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662213
This trial is looking for adults with type 2 diabetes who struggle to manage their condition. Participants will compare the effectiveness of a new drug, elecoglipron, with an existing treatment, semaglutide.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
PHASE3 Sun City, Arizona +4 sites NCT07662135
This trial is looking for adults with type 2 diabetes and kidney problems. Participants will take either elecoglipron or a placebo while continuing their diabetes medications.
Recruiting
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
PHASE3 Birmingham, Alabama +4 sites NCT07797335
This trial is looking for adults with type 2 diabetes who are at high risk for heart problems. Participants will receive injections of either zenagamtide or insulin glargine once a week to see which works better for controlling blood sugar and weight.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662044
This trial is looking for adults with type 2 diabetes that is not well controlled. Participants will take elecoglipron alone or with another medication and compare the effects to a placebo.
Recruiting
Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus
PHASE2 Mesa, Arizona +4 sites NCT07527650
This trial is looking for adults with type 2 diabetes to test a new treatment called HM15275. Participants will be monitored for 36 weeks to see how well the treatment works and if it is safe.
Recruiting
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
PHASE2 San Francisco, California +4 sites NCT07187531
This trial is looking for people aged 5 to 40 who have recently been diagnosed with Type 1 Diabetes. Participants will receive either the study medication or a placebo and will be monitored for safety and effectiveness.
Recruiting
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
PHASE1 Tucson, Arizona +4 sites NCT06783309
This trial is looking for teenagers and young adults aged 12-35 who have been diagnosed with Type 1 Diabetes in the last 6 months. Participants will take a study medication called CNP-103 and will be monitored for safety and effectiveness over about a year.
Recruiting
A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes
PHASE2 Lancaster, California +4 sites NCT07415954
This trial is looking for adults with type 2 diabetes to test a new medication called NNC0662-0419. Participants will receive either NNC0662-0419, another diabetes medication called semaglutide, or a placebo, to see how well it works and how safe it is.
Recruiting
Social Determinants and a Diabetes Prevention Program Tailored for African Americans
PHASE2 Kansas City, Missouri +1 sites NCT05301413
This trial is looking for Black or African American adults who are overweight and have prediabetes or other related conditions. Participants will join a program focused on diet, exercise, and weight loss to help prevent diabetes.
Recruiting
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
PHASE4 Tuscaloosa, Alabama +4 sites NCT06445946
This trial is looking for pregnant women who are at least 18 years old and have been diagnosed with gestational diabetes, needing medication to manage their blood sugar. It’s important that they do not have any serious kidney problems or other specific health conditions that could complicate the study. Women are also excluded if they have certain fetal conditions or previous diabetes issues before pregnancy.
Recruiting
PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes
PHASE4 Huntsville, Alabama +4 sites NCT05390892
This trial is looking for people with type 2 diabetes and heart disease or at high risk for heart disease. Participants will take one of two medications and will be monitored for heart, kidney, and death-related events over time.
Recruiting
Effects of Hourly Stair-Climbing Exercise Snacks on Metabolic and Vascular Health in Adults With Prediabetes
NA St Louis, Missouri NCT07847684
This trial is looking for adults with prediabetes to see if short stair-climbing breaks can help improve their blood sugar control and heart health. Participants will compare sitting, walking breaks, and stair climbing during three visits.
Recruiting
Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families
NA Kansas City, Missouri +1 sites NCT05268250
This trial is looking for families with children aged 8 to 12 who have type 1 diabetes and experience diabetes distress. Participants will join a program aimed at helping reduce this distress to improve their child's blood sugar control.
Recruiting
Role of KATP Channel Loss in Type 2 Diabetes
NA St Louis, Missouri NCT06830096
Recruiting
Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes
NA St Louis, Missouri NCT06503809
This trial is looking for adults with type 1 diabetes who want to improve their blood sugar control. Participants will follow a very low-carbohydrate ketogenic diet for this study.
Recruiting
Lipoprotein Kinetics in T1D
NA Columbia, Missouri NCT05179954
This trial is looking for adults with type 1 diabetes and healthy individuals to help researchers understand how type 1 diabetes affects heart health. Participants will provide blood samples for testing lipids and glucose levels.
Recruiting

Where the Diabetes studies are in Missouri

  • Research Site, Kansas City7 trials
  • Washington University School of Medicine, St Louis6 trials
  • University of Missouri School of Medicine, Columbia5 trials
  • Clinical Research Professionals, Chesterfield3 trials
  • Research Site, St Louis3 trials
  • Washington University in St. Louis, St Louis3 trials

Counts are recruiting studies listing at least one site in Missouri, from ClinicalTrials.gov, refreshed every two days.

Diabetes clinical trials in Missouri: common questions

How many Diabetes clinical trials are recruiting in Missouri?
TrialFinder currently lists 52 recruiting Diabetes clinical trials with study sites in Missouri. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Diabetes clinical trials located in Missouri?
Study sites for the Diabetes trials listed on this page include St Louis, Kansas City, Columbia. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Diabetes clinical trial in Missouri?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Diabetes trials in Missouri also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Diabetes clinical trial in Missouri?
Each study sets its own criteria based on age, Diabetes diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a diabetes clinical trial if I am already on medication?
Usually yes. Most type 2 diabetes trials enroll people on metformin or other oral medicines and test a new treatment on top of them; some require a stable dose for a few months first. Trials that exclude insulin or a specific drug say so in their criteria.
Do I need to know my A1c to apply?
No. Trials state an A1c range, but the study site measures it at the screening visit. You only need to know that you have been diagnosed and which type.
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Diabetes clinical trials study new treatments for Type 1, Type 2, and gestational diabetes, including insulin therapies, diet interventions, and islet-cell transplants.

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