Ketogenic Diet for Adults with Type 1 Diabetes

Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes

Recruiting N/A Interventional Study
Diabetes Mellitus, Type 1
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
58 (estimated)
Sponsor
Washington University School of Medicine · Other
Who this trial is looking for

This trial is looking for adults with type 1 diabetes who want to improve their blood sugar control. Participants will follow a very low-carbohydrate ketogenic diet for this study.

Are You a Good Fit for This Trial?
Must be taking Insulin
Must not be taking SGLT2 inhibitors
Rules you out AnemiaActive eating disorderMajor psychiatric illness

You may be able to join if

  • I am between 18 and 65 years old.
  • I have been diagnosed with type 1 diabetes for over a year.
  • My HbA1c is between 7.0% and 9.0%.
  • I use an insulin pump or take insulin multiple times a day.
  • I have been using a continuous glucose monitor (CGM) for at least 12 weeks.
  • I can read all device instructions and insulin pump settings.
  • I have stable kidney function with an eGFR of 60 or higher.
  • I have a cellular phone with data capability.

You may not be able to join if

  • My body mass index is below 20.0 or above 34.9.
  • I have severe gastroparesis or have had bariatric surgery.
  • I was hospitalized for diabetes-related issues in the last 12 months.
  • I have poorly controlled high blood pressure.
  • I take diabetes medications other than insulin.
  • I regularly engage in structured exercise for more than 210 minutes per week.
  • I am pregnant, breastfeeding, or not using effective birth control if I could become pregnant.
  • I have significant organ system dysfunction.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

Despite strong evidence that tight control of blood sugar reduces the risk of diabetes complications, most people with type 1 diabetes do not achieve recommended blood sugar targets. This randomized controlled trial will test whether a very-low- carbohydrate ketogenic diet can effectively and safely improve blood sugar control in adults with type 1 diabetes.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age ≥18 and ≤65 years * T1D diagnosed \>1 year prior to screening * HbA1c 7.0%-9.0% * Stable insulin delivery method for the past 30 days * Ability to read all device instructions and insulin pump settings * eGFR ≥60 mL/min/1.73 m2 * Use of an insulin pump or insulin delivery …
Contacts

Tara Wilmot, RDN

314-399-8576

tara.wilmot@wustl.edu

CONTACT

Max C Petersen, MD PhD

314-362-8450

max.p@wustl.edu

CONTACT