No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 45
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
30 (estimated)
Sponsor
University of Missouri-Columbia · Other
Who this trial is looking for
This trial is looking for adults with type 1 diabetes and healthy individuals to help researchers understand how type 1 diabetes affects heart health. Participants will provide blood samples for testing lipids and glucose levels.
Are You a Good Fit for This Trial?
Must be takingInsulin
You may be able to join if
I am between 18 and 45 years old.
I am not pregnant or breastfeeding.
I have a body mass index between 18.5 and 30.0.
My fasting plasma triglyceride level is less than 150 mg/dL.
If I have type 1 diabetes, my HbA1c level is less than 8.0%.
I have been using stable insulin for at least 8 weeks.
If I am a healthy control, my fasting plasma glucose is less than 100 mg/dL.
You may not be able to join if
I exercise more than 1.5 hours per week.
I use tobacco products or drink excessive amounts of alcohol.
I take dietary supplements or medications that affect lipids.
I have hypothyroidism or other disorders affecting lipids.
I had a severe hypoglycemic event that required help in the past 6 months.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigators will compare apolipoprotein and triglyceride kinetics in people wtih T1D and healthy control participants.
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Eligibility Criteria
Inclusion Criteria:
* Age: ≥18 but ≤45 years
* premenopausal/eumenorrheic and not pregnant or breastfeeding
* non-obese (body mass index ≥18.5\<30.0 kg/m2)
* Fasting plasma triglyceride \<150 mg/dL
Additional inclusion criteria for control subjects:
* Fasting plasma glucose \<100 mg/dL
* Plasma g…
Inclusion Criteria:
* Age: ≥18 but ≤45 years
* premenopausal/eumenorrheic and not pregnant or breastfeeding
* non-obese (body mass index ≥18.5\<30.0 kg/m2)
* Fasting plasma triglyceride \<150 mg/dL
Additional inclusion criteria for control subjects:
* Fasting plasma glucose \<100 mg/dL
* Plasma glucose 2 h after a 75 g oral glucose challenge \<140 mg/dL
* HbA1c \<5.6%.
Additional inclusion criteria for subjects with T1DM:
* stable insulin regimen (multiple daily insulin injections or continuous subcutaneous insulin) for at least 8 weeks before screening
* no use of diabetes medications other than insulin
* HbA1c \<8.0%, basal (overnight fasted)
* no severe symptomatic hypoglycemic event associated with a seizure or requiring help from other people or a medical facility in the 6 months prior to screening or metabolic testing
Exclusion Criteria:
* more than 1.5 h of structured exercise/week
* use of tobacco products, excessive amounts of alcohol, or dietary supplements and/or medications known to affect lipid metabolism
* hypothyroidism or other disorders known to affect lipid metabolism
* conditions that would make it impossible to complete the study protocol
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