32 Recruiting Trials

Clinical Trials
for Diabetes in Kentucky

32 clinical trials for Diabetes are currently recruiting participants at study sites in Kentucky. Study-related care is provided at no cost.

32
Recruiting trials
28
Study sites
6
Cities
19
Industry-sponsored
5
Phase 2
12
Phase 3

Diabetes clinical trials in Kentucky: what to expect

Diabetes is one of the largest areas of clinical research, and the trials differ a great deal by type. Type 2 studies most often test new glucose-lowering or weight-reducing medicines, once-weekly insulins, and combinations with GLP-1 drugs, in people whose A1c is above goal on their current treatment. Type 1 studies test automated insulin delivery systems, immune therapies for people recently diagnosed or at high risk, and cell-based approaches. Others focus on the complications: kidney disease, eye disease, nerve pain and foot ulcers.

In Kentucky, recruiting diabetes studies are concentrated in Lexington, Louisville, Bowling Green and Edgewood, with sites in 2 other cities. 19 of the 32 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who diabetes trials usually look for

Type 2 trials typically ask for a confirmed diagnosis, an A1c in a stated range (often between 7 and 10.5 percent) and a stable dose of your current medicines for at least a few months. Many exclude recent insulin use, a recent heart attack or stroke, or kidney function below a cut-off. Type 1 trials are often limited by time since diagnosis and by age, and some enroll children and teenagers with a parent's consent.

You do not need to know your A1c or kidney numbers to ask about a trial; the site measures them at screening.

What taking part involves

Screening includes blood work and a review of your history. Medicine trials usually last six months to three years with visits every one to three months, and many provide a glucose monitor and supplies for the duration. Some compare a new drug with a standard one rather than a placebo, so everyone receives active treatment; others include a placebo arm, and the consent form says which. Study drugs, devices, visits and labs are provided at no cost, and most trials pay for time and travel.

Questions worth asking the study team

Whether you would stay on your current medicines; whether there is a placebo group; how often visits are and whether any can be done remotely; and whether your own doctor will receive the results of study labs. If you have type 1 diabetes, ask whether the study uses your own pump or monitor.

Showing 20 of 32 recruiting Diabetes trials in Kentucky

Leveraging Community-clinical Linkages to Address Unmet Social Needs for People With Diabetes
NA Lexington, Kentucky NCT07196007
This trial is looking for adults with diabetes who are patients at specific clinics in rural Kentucky. Participants will receive support to help meet their social needs related to managing diabetes.
Recruiting
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
PHASE3 Anniston, Alabama +4 sites NCT07064473
This trial is looking for adults with type 2 diabetes, high blood pressure, and heart disease. Participants will take either the study medication or a placebo daily for up to 4 years.
Recruiting
A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
PHASE3 Birmingham, Alabama +4 sites NCT07754461
This trial is looking for adults with type 2 diabetes who want to try a new medicine called survodutide to help control their blood sugar levels. Participants will receive either the medicine or a placebo and will continue their usual diabetes treatments over about 14 months with regular check-ins.
Recruiting
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
PHASE3 Scottsdale, Arizona +4 sites NCT07088068
This trial is looking for young people ages 1 to 25 who have recently been diagnosed with stage 3 type 1 diabetes. Participants will receive either teplizumab or a placebo through an IV to see how it affects their blood sugar control over 52 weeks.
Recruiting
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
PHASE3 Louisville, Kentucky +4 sites NCT07222137
This trial is looking for children and adults who are at high risk for type 1 diabetes, meaning they have certain markers in their blood that suggest they might develop the condition soon. To participate, you should be at least 18 pounds in weight and not have any other types of diabetes or serious heart-related issues. They also won't be able to include anyone who has had certain serious infections or health problems.
Recruiting
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662213
This trial is looking for adults with type 2 diabetes who struggle to manage their condition. Participants will compare the effectiveness of a new drug, elecoglipron, with an existing treatment, semaglutide.
Recruiting
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
PHASE3 Birmingham, Alabama +4 sites NCT07797335
This trial is looking for adults with type 2 diabetes who are at high risk for heart problems. Participants will receive injections of either zenagamtide or insulin glargine once a week to see which works better for controlling blood sugar and weight.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662044
This trial is looking for adults with type 2 diabetes that is not well controlled. Participants will take elecoglipron alone or with another medication and compare the effects to a placebo.
Recruiting
A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)
PHASE3 Tucson, Arizona +4 sites NCT06739122
This trial is looking for children with Type 2 diabetes to test different doses of a medication called dulaglutide. Participation will last about 8 months and requires being treated with certain diabetes medications.
Recruiting
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
PHASE2 Chandler, Arizona +4 sites NCT07296484
This trial is looking for adults who are at least 18 years old and have type 2 diabetes that isn’t well controlled. They should have been on stable diabetes medications for a while and show signs of high cortisol levels. However, it won't include anyone who just started having diabetes, has serious low blood sugar issues, or works night shifts regularly.
Recruiting
Time-restricted Eating for Patients With Type 2 Diabetes
NA Lexington, Kentucky NCT07318207
This trial is looking for individuals with type 2 diabetes. Participants will follow a 10-hour eating schedule for one year to study its effects on their condition.
Recruiting
Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery
NA Louisville, Kentucky +2 sites NCT06880835
This trial is looking for adults with type 1 diabetes who use specific insulin pumps. Participants will compare inhaled insulin taken during meals with insulin delivered through their pump while exercising after a meal.
Recruiting
Safety and Efficacy of Adjunct Therapies in Adults With Type 1 Diabetes: Multicenter, Registry Study
N/A Newport Beach, California +4 sites NCT07676565
This trial is looking for adults with Type 1 Diabetes who have been prescribed certain medications as part of their care. Participants will be monitored for one year to see how these treatments work alongside insulin.
Recruiting
Registry for Stage 2 Type 1 Diabetes
N/A Los Angeles, California +4 sites NCT06481904
This trial is looking for people diagnosed with Stage 2 Type 1 Diabetes. Participants will either be starting or have recently started treatment with TZIELD, and the study will gather information on their health and the effects of the treatment over time.
Recruiting
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
PHASE4 Lexington, Kentucky NCT05051436
This trial is looking for people with prediabetes who are overweight or obese. Participants will take either mirabegron, tadalafil, both medications, or a placebo for 14 weeks to see how these treatments affect blood sugar levels.
Recruiting
A Causative Role for Amylin in Diabetic Peripheral Neuropathy
N/A Lexington, Kentucky +1 sites NCT03481283
This trial is looking for people with Type-2 diabetes and nerve pain. Participants will provide blood and skin samples and undergo tests to measure their sensitivity to heat, cold, and pressure.
Recruiting
Mechanisms for Activation of Beige Adipose Tissue in Humans
PHASE2 Lexington, Kentucky NCT04666636
This trial is looking for adults with prediabetes to test how a medication called mirabegron affects blood sugar control and body fat. Participants will need to meet certain health criteria to join the study.
Recruiting
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
NA Chandler, Arizona +4 sites NCT06112418
This trial is looking for older adults with diabetes or risk factors for heart disease. Participants will be randomly assigned to receive different types of care to see which approach is better at preventing heart problems.
Recruiting
OASIS: Peer Support for T2DM in Appalachia (Peer Coaches)
NA Bowling Green, Kentucky +1 sites NCT06003634
Recruiting
OASIS: Peer Support for T2DM in Appalachia (Peer Participant)
NA Bowling Green, Kentucky +1 sites NCT06336122
This trial is looking for older adults with unmanaged type 2 diabetes who live in rural Kentucky. Participants will receive support from trained peer coaches to help manage their diabetes and set personal goals.
Recruiting

Where the Diabetes studies are in Kentucky

  • University of Louisville, Louisville5 trials
  • University of Kentucky, Lexington4 trials
  • Barren River Area Development District, Bowling Green2 trials
  • The Research Group of Lexington LLC, Lexington2 trials
  • UK HealthCare, Hazard2 trials
  • AMR Clinical, Lexington1 trial

Counts are recruiting studies listing at least one site in Kentucky, from ClinicalTrials.gov, refreshed every two days.

Diabetes clinical trials in Kentucky: common questions

How many Diabetes clinical trials are recruiting in Kentucky?
TrialFinder currently lists 32 recruiting Diabetes clinical trials with study sites in Kentucky. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Diabetes clinical trials located in Kentucky?
Study sites for the Diabetes trials listed on this page include Lexington, Louisville, Bowling Green. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Diabetes clinical trial in Kentucky?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Diabetes trials in Kentucky also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Diabetes clinical trial in Kentucky?
Each study sets its own criteria based on age, Diabetes diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a diabetes clinical trial if I am already on medication?
Usually yes. Most type 2 diabetes trials enroll people on metformin or other oral medicines and test a new treatment on top of them; some require a stable dose for a few months first. Trials that exclude insulin or a specific drug say so in their criteria.
Do I need to know my A1c to apply?
No. Trials state an A1c range, but the study site measures it at the screening visit. You only need to know that you have been diagnosed and which type.
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Diabetes clinical trials study new treatments for Type 1, Type 2, and gestational diabetes, including insulin therapies, diet interventions, and islet-cell transplants.

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