Parkinson's Trials / Trials in Kentucky
11 Recruiting Trials

Clinical Trials
for Parkinson's in Kentucky

11 clinical trials for Parkinson's are currently recruiting participants at study sites in Kentucky. Study-related care is provided at no cost.

11
Recruiting trials
8
Study sites
2
Cities
5
Industry-sponsored
3
Phase 2
1
Phase 3

Parkinson's clinical trials in Kentucky: what to expect

Parkinson's trials fall into three groups. Disease-modifying studies test drugs meant to slow progression, including treatments aimed at alpha-synuclein, repurposed diabetes drugs and therapies for people with LRRK2 or GBA gene variants. Symptom studies test new ways to smooth out "off" periods and dyskinesia, and procedures such as focused ultrasound and deep brain stimulation. And a large number of studies involve no medicine: exercise, speech and balance programs, wearables, and long-term observational studies that track the disease.

In Kentucky, recruiting parkinson's studies are concentrated in Lexington and Louisville. 5 of the 11 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who Parkinson's trials usually look for

Disease-modifying trials usually enroll people diagnosed in the last two to five years, sometimes before any Parkinson's medicine has started. Symptom trials want people on levodopa who have a stated number of hours of "off" time a day. Most set ages 30 to 80, exclude dementia and atypical parkinsonism, and may require a dopamine transporter scan to confirm the diagnosis. Genetic trials test for the variant at no cost. Exercise and observational studies accept a much wider range.

What taking part involves

Screening includes a movement exam, sometimes performed both before and after your morning dose, blood work and a scan. Drug trials run twelve weeks to two years with monthly visits, symptom diaries and, in some, a spinal fluid test. Placebo arms are common and medicines you already take generally continue. Exercise and rehabilitation trials involve sessions two or three times a week for several months. Everything study-related is free and travel is usually reimbursed; a care partner is welcome and sometimes required.

Questions worth asking the study team

Whether you must skip a dose before visits; whether your current medicines continue; what the chance of placebo is and whether an extension follows; how many visits are required; and whether you will be told the results of any scans or genetic tests.

Showing 11 of 11 recruiting Parkinson's trials in Kentucky

A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease
PHASE1 Lexington, Kentucky +1 sites NCT06753331
This trial is looking for adults with Parkinson's disease who have been living with the condition for at least 4 years and are not fully controlling their symptoms with current medications. Participants will receive a treatment called DSP-1083 to evaluate its safety and how well it works.
Recruiting
A Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Brain for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery
PHASE1 Lexington, Kentucky NCT06683378
This trial is looking for people with Parkinson's Disease who are scheduled to have deep brain stimulation (DBS) surgery. Participants will receive a treatment involving nerve tissue during their surgery and will be monitored for changes in their health over time.
Recruiting
Parkinson's Foundation PD GENEration Genetic Registry
N/A Birmingham, Alabama +4 sites NCT04994015
This trial is looking for people with Parkinson's disease who are willing to undergo genetic testing. Participants will help build a genetic database for future research on the condition.
Recruiting
A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease
PHASE3 Scottsdale, Arizona +4 sites NCT06944522
This trial is looking for adults with Parkinson's Disease who are between 45 and 75 years old. Participants will receive a treatment called bemdaneprocel to see how well it works and if it is safe.
Recruiting
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
PHASE4 Tucson, Arizona +4 sites NCT04373317
This trial is looking for veterans aged 40 or older who have Parkinson's disease and experience symptoms like hallucinations or delusions. Participants will take either Pimavanserin or Quetiapine, and will need to attend study visits regularly.
Recruiting
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
PHASE2 Sun City, Arizona +4 sites NCT06680830
This trial is looking for men and women aged 40-80 who have early Parkinson's Disease and a specific genetic profile. Participants will take part in a study to evaluate the safety and effectiveness of a new treatment called NEU-411.
Recruiting
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
PHASE2 Little Rock, Arkansas +4 sites NCT07432958
This trial is looking for people with Parkinson's disease who have motor fluctuations while taking their medication. Participants will receive either the study drug AP-472 or a placebo for about 12 weeks to see how well it works.
Recruiting
Spinal Cord Stimulation for Parkinson's Disease Rehabilitation
NA Louisville, Kentucky NCT06804642
This trial is looking for adults with Parkinson's disease to test a treatment called spinal cord transcutaneous stimulation. Participants will help researchers understand how this treatment may improve walking and balance.
Recruiting
Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease
N/A Louisville, Kentucky +4 sites NCT07428447
This trial is looking for adults aged 50 to 85 with essential tremor. Participants will undergo a simple skin biopsy to help identify those at risk of developing Parkinson's disease.
Recruiting
Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies
PHASE1 Lexington, Kentucky NCT06683365
This trial is looking for people diagnosed with Parkinson's disease or Multiple System Atrophy. Participants will have a small nerve graft surgery and will be monitored for a year to see how it affects their condition.
Recruiting
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
N/A Tucson, Arizona +4 sites NCT04071847
This trial is looking for people who need deep brain stimulation surgery for conditions like Parkinson's disease or tremors. Participants will help evaluate the long-term safety and effectiveness of the Abbott DBS system.
Recruiting
See all 11 Parkinson's trials in Kentucky

Where the Parkinson's studies are in Kentucky

Research sites running the most studies
  • University of Kentucky, Lexington4 trials
  • Frazier Rehab Institute, Louisville1 trial
  • Kentucky Neuroscience Institute (Site #213), Lexington1 trial
  • Lexington VA Medical Center, Lexington, KY, Lexington1 trial
  • Norton Healthcare, Louisville1 trial
  • University of Kentucky Medical Center, Lexington1 trial
By city

Counts are recruiting studies listing at least one site in Kentucky, from ClinicalTrials.gov, refreshed every two days.

Parkinson's clinical trials in Kentucky: common questions

How many Parkinson's clinical trials are recruiting in Kentucky?
TrialFinder currently lists 11 recruiting Parkinson's clinical trials with study sites in Kentucky. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Parkinson's clinical trials located in Kentucky?
Study sites for the Parkinson's trials listed on this page include Lexington, Louisville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Parkinson's clinical trial in Kentucky?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Parkinson's trials in Kentucky also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Parkinson's clinical trial in Kentucky?
Each study sets its own criteria based on age, Parkinson's diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a Parkinson's trial if I take carbidopa-levodopa?
Yes for most trials, including every study of "off" time. Some disease-modifying trials want people who have not started medicine yet; the listing says so.
What does "off time" mean in a trial listing?
The hours each day when your medicine has worn off and symptoms return. Trials of new symptom treatments usually require about two or more hours of off time a day, recorded in a diary during screening.
Are there Parkinson's trials that do not involve medicine?
Many. Exercise, speech, balance and dance programs, wearable sensors, deep brain stimulation settings and observational studies all recruit, and most accept people at any stage who can attend sessions.
Parkinson's Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Parkinson's Trials

Parkinson's disease trials test dopamine-replacement therapies, deep brain stimulation, gene therapies, and neuroprotective compounds to slow disease progression.

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