Parkinson's Trials / Trials in Massachusetts
26 Recruiting Trials

Clinical Trials
for Parkinson's in Massachusetts

26 clinical trials for Parkinson's are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.

26
Recruiting trials
23
Study sites
5
Cities
12
Industry-sponsored
5
Phase 2
3
Phase 3

Parkinson's clinical trials in Massachusetts: what to expect

Parkinson's trials fall into three groups. Disease-modifying studies test drugs meant to slow progression, including treatments aimed at alpha-synuclein, repurposed diabetes drugs and therapies for people with LRRK2 or GBA gene variants. Symptom studies test new ways to smooth out "off" periods and dyskinesia, and procedures such as focused ultrasound and deep brain stimulation. And a large number of studies involve no medicine: exercise, speech and balance programs, wearables, and long-term observational studies that track the disease.

In Massachusetts, recruiting parkinson's studies are concentrated in Boston, Cambridge, Allston and Charlestown, with sites in 1 other city. 12 of the 26 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who Parkinson's trials usually look for

Disease-modifying trials usually enroll people diagnosed in the last two to five years, sometimes before any Parkinson's medicine has started. Symptom trials want people on levodopa who have a stated number of hours of "off" time a day. Most set ages 30 to 80, exclude dementia and atypical parkinsonism, and may require a dopamine transporter scan to confirm the diagnosis. Genetic trials test for the variant at no cost. Exercise and observational studies accept a much wider range.

What taking part involves

Screening includes a movement exam, sometimes performed both before and after your morning dose, blood work and a scan. Drug trials run twelve weeks to two years with monthly visits, symptom diaries and, in some, a spinal fluid test. Placebo arms are common and medicines you already take generally continue. Exercise and rehabilitation trials involve sessions two or three times a week for several months. Everything study-related is free and travel is usually reimbursed; a care partner is welcome and sometimes required.

Questions worth asking the study team

Whether you must skip a dose before visits; whether your current medicines continue; what the chance of placebo is and whether an extension follows; how many visits are required; and whether you will be told the results of any scans or genetic tests.

Showing 20 of 26 recruiting Parkinson's trials in Massachusetts

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
PHASE3 Birmingham, Alabama +4 sites NCT07174310
This trial is looking for people with early-stage Parkinson's disease who are currently on stable treatment with levodopa. Participants will receive either the drug prasinezumab or a placebo to study its effects.
Recruiting
Parkinson's Foundation PD GENEration Genetic Registry
N/A Birmingham, Alabama +4 sites NCT04994015
This trial is looking for people with Parkinson's disease who are willing to undergo genetic testing. Participants will help build a genetic database for future research on the condition.
Recruiting
A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications
N/A Phoenix, Arizona +4 sites NCT07330258
This trial is looking for people with Parkinson's disease who still have movement symptoms even though they are on medication. Participants will help researchers understand how the condition changes over time without altering their current treatment.
Recruiting
A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease
PHASE3 Scottsdale, Arizona +4 sites NCT06944522
This trial is looking for adults with Parkinson's Disease who are between 45 and 75 years old. Participants will receive a treatment called bemdaneprocel to see how well it works and if it is safe.
Recruiting
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease
N/A Boston, Massachusetts +4 sites NCT04991831
This trial is looking for adults with tremors from Parkinson's disease. Participants will undergo a specific procedure to see how safe and effective it is over time.
Recruiting
PET Imaging Evaluation of [11C]SY08
EARLY_PHASE1 Charlestown, Massachusetts NCT06098612
This trial is looking for participants aged 50-80 with dementia and certain movement disorders. Involvement includes a PET scan where a small amount of a tracer will be injected to help understand brain function.
Recruiting
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
N/A Aliso Viejo, California +4 sites NCT02071134
This trial is looking for adults with Parkinson’s disease to evaluate a device called the Vercise DBS System. Participants will help gather information on the device's effectiveness in treating their condition.
Recruiting
A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson Disease
NA Boston, Massachusetts +2 sites NCT07705373
This trial is looking for people with Parkinson's disease who can walk independently and are willing to try a new walking program that uses music to help improve their walking. Participants will join for about 18 weeks and will have four visits at research centers.
Recruiting
Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients
NA Boston, Massachusetts +1 sites NCT07455760
This trial is looking for adults with Parkinson's disease or essential tremor who have deep brain stimulation devices. Participants will perform speech tasks while some conditions of their treatment are changed to study how their brain circuits work in speech learning and production.
Recruiting
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
PHASE2 Sun City, Arizona +4 sites NCT06680830
This trial is looking for men and women aged 40-80 who have early Parkinson's Disease and a specific genetic profile. Participants will take part in a study to evaluate the safety and effectiveness of a new treatment called NEU-411.
Recruiting
GBPDC: Gut-Brain in PD Consortium Master Protocol
N/A Boston, Massachusetts +4 sites NCT07567794
This trial is looking for people with Parkinson's disease and those without it to study the gut-brain connection. Participants will undergo various health assessments, including questionnaires, tests, and samples of blood and stool, over a period of up to 24 months.
Recruiting
A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease
PHASE2 Birmingham, Alabama +4 sites NCT06976268
This trial is looking for adults aged 40 to 80 with early Parkinson's disease. Participants will receive treatment over 48 weeks, followed by another 48 weeks of open access to the treatment.
Recruiting
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
PHASE2 Little Rock, Arkansas +4 sites NCT07432958
This trial is looking for people with Parkinson's disease who have motor fluctuations while taking their medication. Participants will receive either the study drug AP-472 or a placebo for about 12 weeks to see how well it works.
Recruiting
Low-dose Carbon Monoxide (HBI-002) Trial to Evaluate Safety, Tolerability, PK, and Biomarkers in Parkinson's Disease
PHASE2 Boston, Massachusetts +4 sites NCT07005180
This trial is looking for people between the ages of 40 and 80 who have been diagnosed with Parkinson's disease and have been using a specific Parkinson's medication for at least a month. It’s important that they haven’t smoked in the last five years and that they are generally in good health. Also, they need to have someone at home who can help keep an eye on them after taking the medication.
Recruiting
A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)
PHASE2 Phoenix, Arizona +4 sites NCT06285643
This trial is looking for adults aged 45-75 with moderate Parkinson's disease. Participants will receive a treatment involving a surgical procedure and will be monitored for safety and effectiveness.
Recruiting
Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons
PHASE1 Boston, Massachusetts NCT06687837
This trial is looking for adults with Parkinson's disease to test a new treatment. Participants will have nerve cells made from their own skin transplanted into their brains.
Recruiting
Dance and Energy Expenditure Among Adults With Parkinson's
NA Boston, Massachusetts NCT06425731
This trial is looking for adults with Parkinson's disease to take part in dance classes. Participants will help researchers understand how dancing and technology can be used to improve their condition.
Recruiting
High Frequency Light, Sound, and Tactile Stimulation to Improve Motor and Cognitive Deficits in Parkinson's Disease
NA Cambridge, Massachusetts NCT05268887
This trial is looking for people with mild Parkinson's disease. Participants will receive therapy using light, sound, and touch while their brain activity is monitored.
Recruiting
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
N/A Birmingham, Alabama +4 sites NCT04477785
This trial is looking for people with Parkinson's disease, healthy volunteers, or those at risk of Parkinson's. Participants will help researchers understand how the disease progresses and identify markers for future treatments.
Recruiting
Robotic Apparel to Prevent Freezing of Gait in Parkinson Disease
NA Allston, Massachusetts +1 sites NCT06602544
This trial is looking for adults with Parkinson's Disease who experience freezing of gait. Participants will use soft robotic apparel to help improve their walking before freezing episodes occur.
Recruiting
See all 26 Parkinson's trials in Massachusetts

Where the Parkinson's studies are in Massachusetts

Research sites running the most studies
  • Massachusetts General Hospital, Boston8 trials
  • Beth Israel Deaconess Medical Center, Boston3 trials
  • Boston University, Boston2 trials
  • Brigham and Women's Hospital, Boston2 trials
  • BMC Community Hospital, Boston1 trial
  • Beth Israe Deaconess Medical Center, Boston1 trial
By city

Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.

Parkinson's clinical trials in Massachusetts: common questions

How many Parkinson's clinical trials are recruiting in Massachusetts?
TrialFinder currently lists 26 recruiting Parkinson's clinical trials with study sites in Massachusetts. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Parkinson's clinical trials located in Massachusetts?
Study sites for the Parkinson's trials listed on this page include Boston, Charlestown, Cambridge, Allston. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Parkinson's clinical trial in Massachusetts?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Parkinson's trials in Massachusetts also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Parkinson's clinical trial in Massachusetts?
Each study sets its own criteria based on age, Parkinson's diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a Parkinson's trial if I take carbidopa-levodopa?
Yes for most trials, including every study of "off" time. Some disease-modifying trials want people who have not started medicine yet; the listing says so.
What does "off time" mean in a trial listing?
The hours each day when your medicine has worn off and symptoms return. Trials of new symptom treatments usually require about two or more hours of off time a day, recorded in a diary during screening.
Are there Parkinson's trials that do not involve medicine?
Many. Exercise, speech, balance and dance programs, wearable sensors, deep brain stimulation settings and observational studies all recruit, and most accept people at any stage who can attend sessions.
Parkinson's Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Parkinson's Trials

Parkinson's disease trials test dopamine-replacement therapies, deep brain stimulation, gene therapies, and neuroprotective compounds to slow disease progression.

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