No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
45 – 90
Sex
Any
Study type
Interventional
Purpose
Supportive Care
Participants needed
40 (estimated)
Sponsor
Massachusetts Institute of Technology · Other
Who this trial is looking for
This trial is looking for people with mild Parkinson's disease. Participants will receive therapy using light, sound, and touch while their brain activity is monitored.
Are You a Good Fit for This Trial?
Must be takingAntiparkinsonian agents
Rules you outAtypical Parkinson's syndromeDementiaProgressive Supranuclear PalsyMultiple System AtrophyCorticobasal DegenerationLewy Body dementia
You may be able to join if
I have been diagnosed with Parkinson's disease.
I am between 45 and 90 years old.
I can speak, read, and understand English.
I can give informed written consent.
I require a stable dose of Parkinson's medication.
I have undergone a brain CT or MRI.
I have a Montreal Cognitive Assessment score of 26 or higher.
I am at Hoehn & Yahr stage 2 to 3.
You may not be able to join if
I have a history of psychiatric illness that could be a safety risk.
I have been diagnosed with dementia or other neurological conditions.
I am currently taking sedative medications.
I have changed my medication in the past month.
I have had recent drug or alcohol abuse.
I have a history of epilepsy, stroke, or seizure in the past 24 months.
I am pregnant.
I have certain implantable medical devices.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Parkinson's disease (PD) impacts different types of neural oscillations in the brain, including beta (13-30Hz) and gamma oscillations (30-80Hz), which contributes to PD's cardinal symptoms of resting tremor, rigidity, bradykinesia (slowness of movement), and gait instability. The investigators' lab has developed a non-invasive method of increasing gamma power in the brain using Gamma Entrainment U…
Parkinson's disease (PD) impacts different types of neural oscillations in the brain, including beta (13-30Hz) and gamma oscillations (30-80Hz), which contributes to PD's cardinal symptoms of resting tremor, rigidity, bradykinesia (slowness of movement), and gait instability. The investigators' lab has developed a non-invasive method of increasing gamma power in the brain using Gamma Entrainment Using Sensory Stimulation (GENUS) through light, sound, and tactile stimulation devices. For this study, 40 participants with mild Parkinson's disease will be recruited, and the investigators will assess their brain waves with electroencephalogram (EEG) before, during, and after light, sound, and tactile stimulation to determine the safety, feasibility, and optimization of GENUS as a potential therapy in the PD population.
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Eligibility Criteria
Inclusion Criteria:
* Subject has Idiopathic PD defined by the cardinal sign, bradykinesia, plus the presence of at least 1 of the following: resting tremor or rigidity and without any other known or suspected cause of Parkinsonism (according to Movement disorder society (MDS) clinical diagnostic c…
Inclusion Criteria:
* Subject has Idiopathic PD defined by the cardinal sign, bradykinesia, plus the presence of at least 1 of the following: resting tremor or rigidity and without any other known or suspected cause of Parkinsonism (according to Movement disorder society (MDS) clinical diagnostic criteria for Parkinson's disease confirmed by a fellowship trained movements disorder specialist
* Subject is Hoehn \& Yahr stage 2 to 3
* Subject has a Montreal Cognitive Assessment (MOCA) score ≥26.
* Subject is \> 45 and \<90 years of age.
* proficient in speaking, reading, and understanding English
* capable of providing informed written consent
* Subject is on a stable dose (at least 1 month prior to baseline visit) of antiparkinsonian agents and willing to remain on this dose for the duration of the study. If on a cholinesterase inhibitor, a stable dose without changes for 1 month is required.
* Subject has undergone a brain CT or MRI prior to rule out underlying structural lesions
Exclusion criteria:
* Subject has atypical Parkinson's syndrome(s) due to drugs, metabolic neurogenetic disorders (e.g., Wilson's Disease), encephalitis, cerebrovascular disease, or degenerative disease (e.g., Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Lewy Body dementia)
* history of any psychiatric illness that would pose a safety risk
* diagnosis of dementia or other neurological conditions
* currently taking sedative medications that are clinically contraindicated
* has undergone recent change (\<1 month) in medication
* recent drug or alcohol abuse or dependence
* laboratory results the would pose safety risk
* concurrently or has participated in other clinical trial investigation within 3 months
* pregnant
* no healthcare
* history of epilepsy, stroke, or seizure in past 24 months
* diagnosis of migraines
* have certain implantable medical devices
* contraindications for MRI
* life expectancy of less than 2 years
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