Clinical Trials
for COPD in Massachusetts
23 clinical trials for COPD are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.
COPD clinical trials in Massachusetts: what to expect
COPD trials test new inhaler combinations, biologic injections for people whose flare-ups continue despite inhalers, and treatments for the cough and mucus that come with chronic bronchitis. Others study pulmonary rehabilitation and exercise, valves and other procedures for emphysema, home oxygen and remote monitoring, and programs to stop smoking. Most enroll people with moderate to severe disease who still have symptoms on their current treatment.
In Massachusetts, recruiting copd studies are concentrated in Boston, North Dartmouth, Burlington and Fall River, with sites in 2 other cities. 12 of the 23 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who COPD trials usually look for
Trials confirm COPD with a breathing test at screening and set a range for lung function, usually between 30 and 80 percent of predicted. Most ask for a smoking history of at least ten pack-years, though current smokers are generally accepted. Biologic trials require one or two flare-ups in the past year needing steroids or antibiotics and sometimes a blood eosinophil count above a threshold. Common exclusions are asthma as the main diagnosis, another significant lung disease and a flare-up in the past four weeks. Ages are usually 40 to 80.
What taking part involves
Screening includes spirometry, blood work and a symptom questionnaire, then a short run-in while you record symptoms. Drug trials run six to twelve months with visits every four to twelve weeks, breathing tests, a six-minute walk in some, and a diary or app. Your maintenance inhalers continue, sometimes replaced by study-supplied versions, and rescue inhaler is always allowed. Rehabilitation trials involve two or three sessions a week for eight to twelve weeks. Study care is free and visits are usually paid.
Questions worth asking the study team
Whether your inhalers stay the same; how breathing tests and walking tests are scheduled; the chance of placebo; what to do during a flare-up while enrolled; and whether oxygen users are accepted.
Showing 20 of 23 recruiting COPD trials in Massachusetts
Where the COPD studies are in Massachusetts
- Beth Israel Deaconess Medical Center, Boston6 trials
- Brigham and Women's Hospital, Boston4 trials
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston2 trials
- BIDMC, Boston1 trial
- Brigham & Women's Hospital- Site Number : 8400148, Boston1 trial
- Brigham Lung Center, Boston1 trial
Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.
COPD clinical trials in Massachusetts: common questions
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