45 Recruiting Trials
Clinical Trials
for Hypertension in Massachusetts
45 clinical trials for Hypertension are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.
45
Recruiting trials
47
Study sites
14
Cities
23
Industry-sponsored
9
Phase 2
7
Phase 3
Hypertension clinical trials in Massachusetts: what to expect
High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.
In Massachusetts, recruiting hypertension studies are concentrated in Boston, Worcester, Methuen and Braintree, with sites in 10 other cities. 23 of the 45 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who hypertension trials usually look for
Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.
What taking part involves
Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.
Questions worth asking the study team
Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.
Showing 20 of 45 recruiting Hypertension trials in Massachusetts
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension
Recruiting
This trial is looking for people with high blood pressure who also have changes in their heart structure. Participants will receive either a mineralocorticoid receptor blocker or a water pill to see which one helps improve heart blood flow and function better.
SPYRAL GEMINI Pilot Study
Recruiting
This trial is looking for people with high blood pressure who are between 18 and 80 years old. Participants will receive a treatment aimed at lowering blood pressure.
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
Recruiting
This trial is looking for patients with heart failure and pulmonary hypertension. Participants will receive a specific treatment and be monitored for three years to evaluate safety and effectiveness.
Improving Hypertension Control in Safety-Net Settings: The Boston Hypertension Equity Alliance in Treatment
Recruiting
This trial is looking for adults with high blood pressure who receive primary care. Participants will work with healthcare providers to improve their blood pressure control.
Groceries for Residents of Southeastern USA to Stop Hypertension
Recruiting
This trial is looking for adults with high blood pressure living in Florida, Georgia, or Tennessee. Participants will receive groceries designed to help lower blood pressure and are required to eat only these groceries for four weeks.
Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation
Recruiting
This trial is looking for Medicare patients with uncontrolled high blood pressure. Participants will be part of a study assessing how well a specific procedure works to lower their blood pressure over time.
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Recruiting
This trial is looking for people who have completed a previous study with sotatercept for pulmonary arterial hypertension (PAH). Participants will be monitored for the long-term safety and tolerance of sotatercept along with their usual PAH treatments.
An Adaptive Program of IKT-001 in Pulmonary Arterial Hypertension (PAH)
Recruiting
This trial is looking for adults with a specific type of high blood pressure in the lungs called pulmonary arterial hypertension (PAH). Participants will take IKT-001 and be monitored for its effectiveness and safety.
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
Recruiting
This trial is looking for adults with pulmonary hypertension and heart failure. Participants will take either a medication called levosimendan or a placebo to see if it improves their walking distance.
LAM-001 for the Treatment of Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Recruiting
This trial is looking for adults aged 18 to 80 with pulmonary hypertension related to interstitial lung disease. Participants will take the study drug and go through regular check-ups to monitor their health and treatment effects.
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
Recruiting
This trial is looking for adults with high blood pressure that is hard to control. Participants will take either the drug RTN-001 or a placebo (a dummy pill) every day for 12 weeks and visit the clinic for checkups.
Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH)
Recruiting
This trial is looking for adults who have been diagnosed with a specific type of high blood pressure in the lungs and who are currently taking stable treatments for it. They should be experiencing mild to moderate limitations in their daily activities. However, people with certain heart or lung diseases, or anyone with a history of severe bleeding issues, won't be eligible to participate.
A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD
Recruiting
This trial is looking for people with pulmonary hypertension related to lung disease who are already using inhaled treprostinil. Participants will take inhaled mosliciguat to see how safe and tolerable it is in this situation.
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Recruiting
This trial is looking for healthy volunteers and patients diagnosed with pulmonary arterial hypertension (PAH). Participants will receive treatment LTP001 and help researchers learn about its effects.
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
Recruiting
This trial is looking for adults who are at least 18 years old and have been diagnosed with a specific lung disease. They need to have a certain level of lung function that is low enough, but they can't already have been diagnosed with high blood pressure in the lungs or have certain heart conditions. It's also important that they haven't had a specific heart test in the last year and are generally healthy enough to participate.
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
Recruiting
This trial is looking for adults with pulmonary hypertension and issues with heart function. Participants will be assessed for safety and effectiveness of a specific treatment device.
Trauma-informed Approach to Timely Detection and Management of Early Postpartum Hypertension
Recruiting
This trial is looking for women who have recently given birth and may experience high blood pressure after delivery. Participants will receive different care approaches to help detect and manage postpartum hypertension and related health issues.
An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH
Recruiting
This trial is looking for people with pulmonary hypertension related to interstitial lung disease. Participants will take part in a treatment involving inhaled medication and undergo assessments to monitor their health.
Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of Pregnancy
Recruiting
This trial is looking for women who had preeclampsia during pregnancy and now have chronic high blood pressure. Participants will take daily capsules and attend several study visits over 48 weeks for monitoring and tests.
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
Recruiting
This trial is looking for people with high blood pressure who need a pacemaker. Participants will try a new treatment that adjusts heart rhythms to help lower blood pressure.
Where the Hypertension studies are in Massachusetts
Research sites running the most studies
- Brigham and Women's Hospital, Boston7 trials
- Massachusetts General Hospital, Boston7 trials
- Beth Israel Deaconess Medical Center, Boston6 trials
- Tufts Medical Center, Boston4 trials
- Boston Children's Hospital, Boston2 trials
- The Brigham and Women's Hospital, Boston2 trials
By city
Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.
Hypertension clinical trials in Massachusetts: common questions
How many Hypertension clinical trials are recruiting in Massachusetts?
TrialFinder currently lists 45 recruiting Hypertension clinical trials with study sites in Massachusetts. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Hypertension clinical trials located in Massachusetts?
Study sites for the Hypertension trials listed on this page include Boston, Worcester. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Hypertension clinical trial in Massachusetts?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Hypertension trials in Massachusetts also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Hypertension clinical trial in Massachusetts?
Each study sets its own criteria based on age, Hypertension diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I stop my blood pressure medicine to join a trial?
Some trials add the study drug to what you take; others standardize or pause your medicines for a few weeks under close monitoring, with rules for stepping in if pressure rises. The listing and consent form state which.
What is ambulatory blood pressure monitoring?
A small cuff and monitor worn for 24 hours that records readings automatically, including during sleep. Trials use it because it is more reliable than clinic readings; the site fits it and you return it the next day.
Is a high reading at home enough to qualify?
It is a reason to ask. Trials confirm eligibility with readings taken at the site after resting, usually on two visits, so a single home reading neither qualifies nor rules you out.
Hypertension Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Hypertension Trials
Hypertension trials study novel antihypertensives, renal denervation, lifestyle interventions, and combination therapies for resistant high blood pressure.
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