36 Recruiting Trials

Clinical Trials
for Hypertension in Minnesota

36 clinical trials for Hypertension are currently recruiting participants at study sites in Minnesota. Study-related care is provided at no cost.

36
Recruiting trials
18
Study sites
8
Cities
14
Industry-sponsored
4
Phase 3

Hypertension clinical trials in Minnesota: what to expect

High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.

In Minnesota, recruiting hypertension studies are concentrated in Rochester, Minneapolis, Coon Rapids and Saint Cloud, with sites in 4 other cities. 14 of the 36 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who hypertension trials usually look for

Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.

What taking part involves

Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.

Showing 20 of 36 recruiting Hypertension trials in Minnesota

Sleep Restriction and Parental History of Hypertension
NA Rochester, Minnesota NCT06482814
This trial is looking for healthy adults between 18 and 35 years old to study how limited sleep affects blood pressure. Participants will have their sleep and health monitored during the study.
Recruiting
HTN App for HTN Control and Cardiovascular Health Among African-Americans
NA Rochester, Minnesota NCT06346886
This trial is looking for African-American adults with high blood pressure who want to improve their blood pressure management using a special app. Participants must be receiving care from a specific health provider and willing to use a smartphone throughout the study.
Recruiting
Study of Disrupted Sleep in Somali Americans
N/A Rochester, Minnesota NCT05411029
This trial is looking for Somali Americans over 18 who have no history of high blood pressure, diabetes, or sleep disorders. Participants will help researchers understand sleep problems and how they might relate to blood pressure levels.
Recruiting
Ultrasound With Subharmonic Imaging and Subharmonic Aided Pressure Estimation (SHAPE) to Identify Portal Hypertension
NA Rochester, Minnesota +2 sites NCT06797193
This trial is looking for adults who need to have their liver pressure measured. Participants will undergo a noninvasive ultrasound test to help identify a condition called portal hypertension.
Recruiting
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
PHASE3 Phoenix, Arizona +4 sites NCT07218029
This trial is looking for people who have completed a previous study with sotatercept for pulmonary arterial hypertension (PAH). Participants will be monitored for the long-term safety and tolerance of sotatercept along with their usual PAH treatments.
Recruiting
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
PHASE3 Alexander City, Alabama +4 sites NCT07288398
This trial is looking for adults with pulmonary hypertension and heart failure. Participants will take either a medication called levosimendan or a placebo to see if it improves their walking distance.
Recruiting
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
NA Birmingham, Alabama +4 sites NCT06911632
This trial is looking for adults who are at least 18 years old and have been diagnosed with a specific lung disease. They need to have a certain level of lung function that is low enough, but they can't already have been diagnosed with high blood pressure in the lungs or have certain heart conditions. It's also important that they haven't had a specific heart test in the last year and are generally healthy enough to participate.
Recruiting
Early Feasibility Study of "HyperQureTM RDN System", Laparoscopic Renal Denervation Therapy, in Patients With Resistant Hypertension
NA Orange, California +4 sites NCT06526858
This trial is looking for adults aged 22 to 80 with resistant hypertension. Participants will undergo a procedure to evaluate a new renal denervation device while continuing their current blood pressure medications.
Recruiting
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
NA Minneapolis, Minnesota +4 sites NCT04555161
This trial is looking for adults with pulmonary hypertension and issues with heart function. Participants will be assessed for safety and effectiveness of a specific treatment device.
Recruiting
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
N/A Birmingham, Alabama +4 sites NCT06388421
This trial is looking for adults with pulmonary hypertension related to interstitial lung disease. Participants will share information about their health and treatments to help improve understanding of these conditions.
Recruiting
An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH
N/A Phoenix, Arizona +4 sites NCT06129240
This trial is looking for people with pulmonary hypertension related to interstitial lung disease. Participants will take part in a treatment involving inhaled medication and undergo assessments to monitor their health.
Recruiting
Recruiting
Pulmonary Hypertension in Left Heart Disease
N/A Rochester, Minnesota NCT05935605
This trial is looking for people with heart disease to compare their condition with varying levels of lung blood flow issues. Participants will undergo heart tests, lung scans, and blood samples.
Recruiting
CVD/PH and Voice Characteristics
N/A Rochester, Minnesota NCT07311044
This trial is looking for patients who are having a routine heart ultrasound (echocardiogram) at Mayo Clinic. The study aims to see if there is a link between voice characteristics and pulmonary hypertension.
Recruiting
Pulmonary Hypertension Association Registry
N/A Phoenix, Arizona +4 sites NCT04071327
This trial is looking for people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Participants will provide information about their health and treatment to help improve care for these conditions.
Recruiting
Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure
EARLY_PHASE1 Minneapolis, Minnesota NCT06507657
This trial is looking for adults over 60 years old who have high blood pressure and a higher body weight. Participants will take either a daily tablet of empagliflozin or a placebo to see how it affects heart function.
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
NA Scottsdale, Arizona +4 sites NCT06059638
This trial is looking for people with high blood pressure who need a pacemaker. Participants will try a new treatment that adjusts heart rhythms to help lower blood pressure.
Recruiting
Global Paradise System US Post Approval Study
N/A Long Beach, California +4 sites NCT06297291
This trial is looking for adults with high blood pressure that isn't controlled by lifestyle changes or medications. Participants will receive treatment with the Paradise Ultrasound Renal Denervation System and help researchers understand its long-term safety and effectiveness.
Recruiting
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
N/A Minneapolis, Minnesota NCT04439370
This trial is looking for women aged 35-70 who have experienced premature or early menopause. Taking part will involve undergoing tests to understand how menopause affects blood pressure regulation.
Recruiting

Where the Hypertension studies are in Minnesota

  • Mayo Clinic, Rochester11 trials
  • University of Minnesota, Minneapolis11 trials
  • Mayo Clinic in Rochester, Rochester7 trials
  • Minneapolis Heart Institute, Minneapolis2 trials
  • CentraCare - St. Cloud Hospital, Saint Cloud1 trial
  • Clinical Trial Site, Richfield1 trial

Counts are recruiting studies listing at least one site in Minnesota, from ClinicalTrials.gov, refreshed every two days.

Hypertension clinical trials in Minnesota: common questions

How many Hypertension clinical trials are recruiting in Minnesota?
TrialFinder currently lists 36 recruiting Hypertension clinical trials with study sites in Minnesota. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Hypertension clinical trials located in Minnesota?
Study sites for the Hypertension trials listed on this page include Rochester, Minneapolis. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Hypertension clinical trial in Minnesota?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Hypertension trials in Minnesota also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Hypertension clinical trial in Minnesota?
Each study sets its own criteria based on age, Hypertension diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I stop my blood pressure medicine to join a trial?
Some trials add the study drug to what you take; others standardize or pause your medicines for a few weeks under close monitoring, with rules for stepping in if pressure rises. The listing and consent form state which.
What is ambulatory blood pressure monitoring?
A small cuff and monitor worn for 24 hours that records readings automatically, including during sleep. Trials use it because it is more reliable than clinic readings; the site fits it and you return it the next day.
Is a high reading at home enough to qualify?
It is a reason to ask. Trials confirm eligibility with readings taken at the site after resting, usually on two visits, so a single home reading neither qualifies nor rules you out.
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Hypertension trials study novel antihypertensives, renal denervation, lifestyle interventions, and combination therapies for resistant high blood pressure.

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