No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
35 – 70
Sex
Female
Study type
Observational
Participants needed
160 (estimated)
Sponsor
University of Minnesota · Other
Who this trial is looking for
This trial is looking for women aged 35-70 who have experienced premature or early menopause. Taking part will involve undergoing tests to understand how menopause affects blood pressure regulation.
Are You a Good Fit for This Trial?
Must not be takingHormonal contraceptivesHormone replacement therapy
You may be able to join if
I am aged 35-70 years old.
I have experienced premature menopause before age 40 or early menopause before age 46.
I am premenopausal and aged 35-49.
I am between 50-70 years old and have gone through typical-age menopause.
My menopause status is confirmed by not having my period for 12 months.
You may not be able to join if
I currently use nicotine or tobacco.
I am diabetic.
I have asthma.
I have been diagnosed with significant carotid stenosis.
I have a history of serious heart disease or autonomic dysfunction.
I have respiratory disease or a severe neurological condition.
I have existing metabolic or endocrine abnormalities.
I am pregnant or breastfeeding.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulati…
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause
* Premenopausal 35-49 years of age
* Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
* Menopause will be confirmed by subject report of amenorrhea fo…
Inclusion Criteria:
* Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause
* Premenopausal 35-49 years of age
* Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
* Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of \>30 mIU/mL
Exclusion Criteria:
* Current nicotine/tobacco use within the past six months
* Are diabetic or asthmatic
* Have diagnosed significant carotid stenosis
* Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury.
* Have existing metabolic or endocrine abnormities
* Take any heart/blood pressure medications that are determined to interfere with study outcomes
* IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes
* Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study
* Are pregnant or breastfeeding
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