Empagliflozin for Heart Failure Risk

Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure

Recruiting Early Phase 1 Interventional Study
Hypertension Cardiovascular Diseases
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
60 and older
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
80 (estimated)
Sponsor
University of Minnesota · Other
Who this trial is looking for

This trial is looking for adults over 60 years old who have high blood pressure and a higher body weight. Participants will take either a daily tablet of empagliflozin or a placebo to see how it affects heart function.

Are You a Good Fit for This Trial?
Rules you out Unstable coronary syndromesAny major surgery in the past 90 days

You may be able to join if

  • I am over 60 years old.
  • I have been diagnosed with high blood pressure.
  • I have a body mass index of 30 or higher.
  • I have had an echocardiogram within the last 60 days.

You may not be able to join if

  • I am pregnant, breastfeeding, or could become pregnant.
  • I have a history of type 1 or type 2 diabetes.
  • I have been diagnosed with heart failure.
  • My heart's left ventricular ejection fraction is 40% or lower.
  • I have had moderate or severe valve disease.
  • I have a history of urinary infections.
  • My kidney function is below a certain level.
  • I am currently on certain heart medications.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce CVD events, including incident HF. SGLT2 is a glucose transport protein in the kidneys. Inhibition of this protein results in glucosuria and lower serum blood sugar. The SGLT2i medications were initially approved to treat type 2 diabetes (T2D). In 2015, Zinman et al. published the first large randomized clinical trial (RCT) demonstrating a …
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age \>60 years of age * Clinical diagnosis of hypertension * Body mass index ≥30kg/m2 * We will screen for participants with an echocardiogram within 60 days of the baseline visit Exclusion Criteria: * Female participants who are pregnant, lactating, or of child bearing pote…
Contacts

Michelle Pitt

612-625-6678

henni032@umn.edu

CONTACT