46 Recruiting Trials
Clinical Trials
for Hypertension in Pennsylvania
46 clinical trials for Hypertension are currently recruiting participants at study sites in Pennsylvania. Study-related care is provided at no cost.
46
Recruiting trials
77
Study sites
31
Cities
22
Industry-sponsored
9
Phase 2
11
Phase 3
Hypertension clinical trials in Pennsylvania: what to expect
High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.
In Pennsylvania, recruiting hypertension studies are concentrated in Philadelphia, Pittsburgh, Hershey and Media, with sites in 27 other cities. 22 of the 46 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who hypertension trials usually look for
Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.
What taking part involves
Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.
Questions worth asking the study team
Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.
Showing 20 of 46 recruiting Hypertension trials in Pennsylvania
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
Recruiting
This trial is looking for patients with heart failure and pulmonary hypertension. Participants will receive a specific treatment and be monitored for three years to evaluate safety and effectiveness.
THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
Recruiting
This trial is looking for adults with hypertension who have not been able to control their blood pressure with medication. Participants will stop taking their blood pressure medications for a short time and receive either the TIVUS treatment or a sham procedure.
Mobile Health Program for Post-Preeclampsia Hypertension
Recruiting
This trial is looking for women who had high blood pressure during pregnancy and now have high blood pressure after giving birth. Participants will use home blood pressure monitoring and receive virtual coaching to help manage their condition.
SHAPE of Portal Hypertension in Children
Recruiting
This trial is looking for children with chronic liver disease to test a new ultrasound method for diagnosing portal hypertension. Participants will not have to undergo invasive procedures.
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
Recruiting
This trial is looking for adults who have completed a previous study with seralutinib. Participants will take seralutinib and be monitored for safety and effectiveness over time.
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Recruiting
This trial is looking for adults with pulmonary hypertension linked to interstitial lung disease. Participants will take either a study drug called TPIP or a placebo once a day for 24 weeks and will be monitored for their exercise ability.
A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)
Recruiting
This trial is looking for adults with pulmonary arterial hypertension (PAH) who want to try a new inhalation treatment. Participants will take the treatment once a day for 24 weeks and will be monitored for changes in their exercise ability.
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Recruiting
This trial is looking for people who have completed a previous study with sotatercept for pulmonary arterial hypertension (PAH). Participants will be monitored for the long-term safety and tolerance of sotatercept along with their usual PAH treatments.
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
Recruiting
This trial is looking for adults with pulmonary hypertension and heart failure. Participants will take either a medication called levosimendan or a placebo to see if it improves their walking distance.
LAM-001 for the Treatment of Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Recruiting
This trial is looking for adults aged 18 to 80 with pulmonary hypertension related to interstitial lung disease. Participants will take the study drug and go through regular check-ups to monitor their health and treatment effects.
A Study of ROC-101 in Patients With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (ILD-PH) (ROCSTAR STUDY)
Recruiting
This trial is looking for adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension related to interstitial lung disease (ILD-PH). Participants will receive standard care plus ROC-101 for 24 weeks, followed by a longer extension period based on the study's progress.
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Recruiting
This trial is looking for healthy volunteers and patients diagnosed with pulmonary arterial hypertension (PAH). Participants will receive treatment LTP001 and help researchers learn about its effects.
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
Recruiting
This trial is looking for children aged 1 to under 18 with pulmonary arterial hypertension (PAH). Participants will receive treatment with sotatercept over 24 weeks to evaluate safety and how the body processes the drug.
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
Recruiting
This trial is looking for adults who are at least 18 years old and have been diagnosed with a specific lung disease. They need to have a certain level of lung function that is low enough, but they can't already have been diagnosed with high blood pressure in the lungs or have certain heart conditions. It's also important that they haven't had a specific heart test in the last year and are generally healthy enough to participate.
Randomized Controlled Trial of Two Mobile Health Strategies to Manage Postpartum Hypertension
Recruiting
This trial is looking for women who have high blood pressure after childbirth. Participants will help compare two different ways to manage their blood pressure through mobile health tools.
Recruiting
Mobile Health Program for Rural Hypertension
Recruiting
This trial is looking for people living in rural areas who have high blood pressure that is not well controlled. Participants will use a home blood pressure monitor and receive support and education to help manage their condition.
Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass
Recruiting
This trial is looking for people with pulmonary arterial hypertension (PAH) to learn how muscle loss affects them. Participants will have various tests and follow-up visits over 6 months to gather information about their condition and health.
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Recruiting
This trial is looking for adults with pulmonary hypertension related to interstitial lung disease. Participants will share information about their health and treatments to help improve understanding of these conditions.
Where the Hypertension studies are in Pennsylvania
Research sites running the most studies
- University of Pennsylvania, Philadelphia5 trials
- Allegheny General Hospital, Pittsburgh3 trials
- Children's Hospital of Philadelphia, Philadelphia3 trials
- Penn State Milton S. Hershey Medical Center, Hershey3 trials
- Suburban Research Associates, West Chester3 trials
- University of Pittsburgh Medical Center, Pittsburgh3 trials
By city
Counts are recruiting studies listing at least one site in Pennsylvania, from ClinicalTrials.gov, refreshed every two days.
Hypertension clinical trials in Pennsylvania: common questions
How many Hypertension clinical trials are recruiting in Pennsylvania?
TrialFinder currently lists 46 recruiting Hypertension clinical trials with study sites in Pennsylvania. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Hypertension clinical trials located in Pennsylvania?
Study sites for the Hypertension trials listed on this page include Pittsburgh, Philadelphia. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Hypertension clinical trial in Pennsylvania?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Hypertension trials in Pennsylvania also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Hypertension clinical trial in Pennsylvania?
Each study sets its own criteria based on age, Hypertension diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I stop my blood pressure medicine to join a trial?
Some trials add the study drug to what you take; others standardize or pause your medicines for a few weeks under close monitoring, with rules for stepping in if pressure rises. The listing and consent form state which.
What is ambulatory blood pressure monitoring?
A small cuff and monitor worn for 24 hours that records readings automatically, including during sleep. Trials use it because it is more reliable than clinic readings; the site fits it and you return it the next day.
Is a high reading at home enough to qualify?
It is a reason to ask. Trials confirm eligibility with readings taken at the site after resting, usually on two visits, so a single home reading neither qualifies nor rules you out.
Hypertension Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Hypertension Trials
Hypertension trials study novel antihypertensives, renal denervation, lifestyle interventions, and combination therapies for resistant high blood pressure.
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