Parkinson's Trials / Trials in Pennsylvania
21 Recruiting Trials

Clinical Trials
for Parkinson's in Pennsylvania

21 clinical trials for Parkinson's are currently recruiting participants at study sites in Pennsylvania. Study-related care is provided at no cost.

21
Recruiting trials
20
Study sites
5
Cities
9
Industry-sponsored
4
Phase 2
2
Phase 3

Parkinson's clinical trials in Pennsylvania: what to expect

Parkinson's trials fall into three groups. Disease-modifying studies test drugs meant to slow progression, including treatments aimed at alpha-synuclein, repurposed diabetes drugs and therapies for people with LRRK2 or GBA gene variants. Symptom studies test new ways to smooth out "off" periods and dyskinesia, and procedures such as focused ultrasound and deep brain stimulation. And a large number of studies involve no medicine: exercise, speech and balance programs, wearables, and long-term observational studies that track the disease.

In Pennsylvania, recruiting parkinson's studies are concentrated in Philadelphia, Pittsburgh, Butler and Exton, with sites in 1 other city. 9 of the 21 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who Parkinson's trials usually look for

Disease-modifying trials usually enroll people diagnosed in the last two to five years, sometimes before any Parkinson's medicine has started. Symptom trials want people on levodopa who have a stated number of hours of "off" time a day. Most set ages 30 to 80, exclude dementia and atypical parkinsonism, and may require a dopamine transporter scan to confirm the diagnosis. Genetic trials test for the variant at no cost. Exercise and observational studies accept a much wider range.

What taking part involves

Screening includes a movement exam, sometimes performed both before and after your morning dose, blood work and a scan. Drug trials run twelve weeks to two years with monthly visits, symptom diaries and, in some, a spinal fluid test. Placebo arms are common and medicines you already take generally continue. Exercise and rehabilitation trials involve sessions two or three times a week for several months. Everything study-related is free and travel is usually reimbursed; a care partner is welcome and sometimes required.

Questions worth asking the study team

Whether you must skip a dose before visits; whether your current medicines continue; what the chance of placebo is and whether an extension follows; how many visits are required; and whether you will be told the results of any scans or genetic tests.

Showing 20 of 21 recruiting Parkinson's trials in Pennsylvania

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
PHASE3 Birmingham, Alabama +4 sites NCT07174310
This trial is looking for people with early-stage Parkinson's disease who are currently on stable treatment with levodopa. Participants will receive either the drug prasinezumab or a placebo to study its effects.
Recruiting
A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease
PHASE1 Englewood, Colorado +4 sites NCT06565195
This trial is looking for healthy volunteers and patients with Parkinson's disease to evaluate the safety and effects of a drug called LY3962681. Participants will receive either the drug or an inactive substance and will be followed up for medical assessments over time.
Recruiting
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)
NA Philadelphia, Pennsylvania +1 sites NCT05070013
This trial is looking for adults with Parkinson's Disease who have problems with sleep. Participants will receive a treatment to improve their sleep quality while also addressing motor symptoms associated with their condition.
Recruiting
Parkinson's Foundation PD GENEration Genetic Registry
N/A Birmingham, Alabama +4 sites NCT04994015
This trial is looking for people with Parkinson's disease who are willing to undergo genetic testing. Participants will help build a genetic database for future research on the condition.
Recruiting
A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications
N/A Phoenix, Arizona +4 sites NCT07330258
This trial is looking for people with Parkinson's disease who still have movement symptoms even though they are on medication. Participants will help researchers understand how the condition changes over time without altering their current treatment.
Recruiting
A Study of Buntanetap in Participants With PD
PHASE2 Birmingham, Alabama +4 sites NCT07284784
This trial is looking for adults with Parkinson's Disease who are either already on deep brain stimulation treatment or have participated in earlier trials with buntanetap. Participants will take the medication for 36 months and attend regular check-ups.
Recruiting
Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging)
PHASE2 Philadelphia, Pennsylvania +4 sites NCT07265596
This trial is looking for adults who have early signs of Parkinson's disease. Participants will have regular check-ups and use a specific imaging method to track changes over two years.
Recruiting
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
PHASE4 Tucson, Arizona +4 sites NCT04373317
This trial is looking for veterans aged 40 or older who have Parkinson's disease and experience symptoms like hallucinations or delusions. Participants will take either Pimavanserin or Quetiapine, and will need to attend study visits regularly.
Recruiting
Enrichment of Glutathione Using Gamma-glutamylcysteine Supplementation in Parkinson's Disease Patients.
PHASE1 Pittsburgh, Pennsylvania NCT07064005
This trial is looking for people with early Parkinson's disease to see how a supplement called gamma-glutamylcysteine affects their health. Participants will take the supplement and have their brain, blood, and gut health checked over time.
Recruiting
Impact of a Biophoton Therapy on Patients With Brain Disorders
NA Butler, Pennsylvania NCT06147999
This trial is looking for adults with brain disorders like Alzheimer's or Parkinson's who can participate in a study. Participants will receive a treatment to see if it helps their condition while being supported by a caregiver.
Recruiting
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
PHASE2 Sun City, Arizona +4 sites NCT06680830
This trial is looking for men and women aged 40-80 who have early Parkinson's Disease and a specific genetic profile. Participants will take part in a study to evaluate the safety and effectiveness of a new treatment called NEU-411.
Recruiting
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications
N/A Philadelphia, Pennsylvania +4 sites NCT05539196
This trial is looking for people aged 30 and older with advanced Parkinson's disease who have motor complications and are planning to receive the Exablate procedure. Participants will need to visit the registry for follow-ups at 3, 6, and 12 months, and then every year for 5 years.
Recruiting
A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)
PHASE2 Phoenix, Arizona +4 sites NCT06285643
This trial is looking for adults aged 45-75 with moderate Parkinson's disease. Participants will receive a treatment involving a surgical procedure and will be monitored for safety and effectiveness.
Recruiting
Parkinson's Disease and Movement Disorders Clinical Database
N/A Philadelphia, Pennsylvania NCT04997642
This trial is looking for people diagnosed with Parkinson's disease who may also have mild cognitive impairment or dementia. Participants will provide health information and may contribute biological samples and brain images.
Recruiting
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
N/A Birmingham, Alabama +4 sites NCT04477785
This trial is looking for people with Parkinson's disease, healthy volunteers, or those at risk of Parkinson's. Participants will help researchers understand how the disease progresses and identify markers for future treatments.
Recruiting
Biofluid Research on Age-Related or Inherited Neurodegeneration
N/A Philadelphia, Pennsylvania NCT07798700
This trial is looking for people diagnosed with neurodegenerative diseases like Alzheimer's or Parkinson's, as well as their family members. Participants will provide blood samples and information about their health and family history.
Recruiting
Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates
PHASE4 Philadelphia, Pennsylvania NCT03495024
This trial is looking for people with schizophrenia or schizoaffective disorder who smoke and have a specific type of movement problem. Participants will take a medication called varenicline to help them stop smoking over 12 weeks while being monitored for changes in their smoking and movement symptoms.
Recruiting
Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control
NA Pittsburgh, Pennsylvania NCT07056361
This trial is looking for patients with essential tremor or Parkinson's disease who are going to have surgery for deep brain stimulation. Participants will have extra testing during their surgery to help understand how the treatment works for movement issues.
Recruiting
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
NA Philadelphia, Pennsylvania NCT06377033
This trial is looking for adults who have been diagnosed with specific genetic conditions. Participants will help test a new way to use electronic health records for genetic testing.
Recruiting
Deep Brain Stimulation (DBS) Retrospective Outcomes Study
N/A Phoenix, Arizona +4 sites NCT03664609
This trial is looking for people who have received or are eligible for deep brain stimulation treatment. Participants will be involved in reviewing past treatment outcomes using patient records.
Recruiting
See all 21 Parkinson's trials in Pennsylvania

Where the Parkinson's studies are in Pennsylvania

Research sites running the most studies
  • University of Pennsylvania, Philadelphia6 trials
  • Allegheny General Hospital, Pittsburgh2 trials
  • Thomas Jefferson University, Philadelphia2 trials
  • University of Pittsburgh, Pittsburgh2 trials
  • Abington Neurology, Willow Grove1 trial
  • Allegheny General Hospital Department of Neurosurgery, Pittsburgh1 trial
By city

Counts are recruiting studies listing at least one site in Pennsylvania, from ClinicalTrials.gov, refreshed every two days.

Parkinson's clinical trials in Pennsylvania: common questions

How many Parkinson's clinical trials are recruiting in Pennsylvania?
TrialFinder currently lists 21 recruiting Parkinson's clinical trials with study sites in Pennsylvania. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Parkinson's clinical trials located in Pennsylvania?
Study sites for the Parkinson's trials listed on this page include Philadelphia, Pittsburgh, Butler. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Parkinson's clinical trial in Pennsylvania?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Parkinson's trials in Pennsylvania also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Parkinson's clinical trial in Pennsylvania?
Each study sets its own criteria based on age, Parkinson's diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a Parkinson's trial if I take carbidopa-levodopa?
Yes for most trials, including every study of "off" time. Some disease-modifying trials want people who have not started medicine yet; the listing says so.
What does "off time" mean in a trial listing?
The hours each day when your medicine has worn off and symptoms return. Trials of new symptom treatments usually require about two or more hours of off time a day, recorded in a diary during screening.
Are there Parkinson's trials that do not involve medicine?
Many. Exercise, speech, balance and dance programs, wearable sensors, deep brain stimulation settings and observational studies all recruit, and most accept people at any stage who can attend sessions.
Parkinson's Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Parkinson's Trials

Parkinson's disease trials test dopamine-replacement therapies, deep brain stimulation, gene therapies, and neuroprotective compounds to slow disease progression.

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